Sleep Trainee Home Page--Trainee Manual-East

EAST
INSTITUTIONS	UNDERGRAD	GRADUATE	POST-DOC	RESIDENCY	INTERNSHIP
1. Allegheny University of the Health Sciences, Dept. of Neurology (Goldberg & Fry)	_	_	*	*	_
2. Brigham & Women's Hospital/Harvard Med. School, (Czeisler)	*	*	*	_	_
2. Brown University School of Medicine (Carskadon)	*	*	*	_	*
4. Brown University School of Medicine (Posner)	_	_	*	?	*
5. City College of NY, Dept. of Psychol. (Spielman)	*	*	_	_	_
6. Columbia Univer. College of Phys. & Surgeons, St. Luke's/Roosevelt Hospital Center, Sleep Disorders Institute (Zammit)	*	*	*	*	?
7. University of Connecticut, Department of Psychology (Tepas)	*	*	_	_	_
8. Cornell Univ. Medical College, Dept. of Psychiatry (Campbell)	*	*	*	_	_
9. Crozer-Chester Medical Center (Stafford)	_	_	_	*	_
10. Univ. of Delaware, Dept. of Psychology (Satinoff)	_	*	*	_	_
11. Harvard Medical School, Dept. of Psychiatry (Dorsey)	*	*	*	_	?
12. Harvard Medical School (Hobson)	_	_	*	_	_
13. Harvard Medical School, Dept. of Psychiatry - VAMC (McCarley)	_	_	*	_	_
14. The College of the Holy Cross, Dept. of Psychology (Wolfson)	*	_	_	_	_
15. Montefiore Medical Center, & Albert Einstein College of Medicine, NY (Thorpy)	_	_	_	*	_
16. Univ. of PA, Dept. of Animal Biology, School of Veterinary Med., Phila., PA (Morrison)	_	*	*	_	_
17. Univ. of PA Med. Ctr., Dept. of Psychiatry (Dinges)	*	*	*	_	_
18. Univ. of PA Med. Ctr., Ctr For Sleep & Respiratory Neurobiology (Pack)	_	_	*	_	_
19. Univ. of Pittsburgh Medical Ctr., Dept. of Psychiatry (Dahl)	*	*	*	?	_
20. Uiv. of Pittsburgh Medical Ctr., Dept. of Psychiatry (Reynolds)	?	*	*	_	_
21. Univ. of Rochester Med. Center, Dept. of Psychiatry, Rochester, NY (Giles & Perlis)	*	*	*	*	*
22. St. Joseph's University and Medical College of Pennsylvania (Mindell)	*	*	_	_	_

* = This type of training exists in the program

_ = This type of training does NOT exist in the program

? = It is not known whether this type of training exists in the program

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1. Affiliation: 1997-1998 Entry - Allegheny University of the Health Sciences, Department of Neurology

2. Name & Address: Rochelle Goldberg, M.D.

Sleep Disorders Center - Allegheny University of the Health Sciences
3200 Henry Avenue
Philadelphia, PA 19129

Phone: (215) 842-4250;
FAX: (215) 848-3850

3. Other Faculty: June M. Fry, M.D., Jodi A. Mindell, Ph.D., A. Sinan Baran, M.D., Mark A. DiPhillipo, R.PSG.T

4. Types Of Training Available: One or two year fellowship in sleep medicine

5. Types Of Funding Available: Salary at the PGY 5 level

6. Names of current trainees: Wissam Chatila, M.D., Shelley Knowles, M.D.

7. Students Who Have Completed Training In The Past Five Years and Current Status:
Arthur J. Kranz, M.D.
Margaret E. Mike, M.D.
Robert Kosinski, M.D.
R. Mollie John, M.D.
Raoul Biniaurshuili, M.D., Ph.D.
Gautam Samadder, M.D.
Debra Ann Pollack, M.D.
Usha Nalamalapu, M.D.
Wissam Chatila, M.D.
Shelley Knowles, M.D.

8. Primary Research Focus Of Laboratory:

+ Sleep disordered breathing
+ Sleep medicine education
+ Clinical trials in insomnia and narcolepsy

9. Technical Capabilities Of The Lab:

* Extensive clinical experience
* Affiliation with major tertiary care facility

10. Primary Training Focus: Multidisciplinary training in all clinical aspects of sleep disorders at the fellowship level.

11. Other Training Opportunities:

Access to ongoing grand rounds and academic specialty conferences throughthout the institution. ; Research projects in clinical
aspects of sleep medicine.

12. Representative Publications For Last Five Years:

Goldberg R, Sexauer W. Noninvasive ventilatory support. Clin Pulm Med 1994; 1(5):313-21.

Bresnitz EA, Goldberg R, Kosinski RM. Epidemiology of obstructive sleep apnea. Epidemiologic Reviews 1994; 16(2):210-227.

Laniado NL, Goldberg R, Fry JM. Addressing snoring and obstructive sleep apnea: A problem often overlooked in women. Compendium 1993; XIV(12):1572-1582.

Margolis MC, Howlett P, Goldberg R, Eftychiadis A, Levine SL. Obstructive sleep apnea syndrome in acid maltase deficiency. Chest 1994; 105(3):947-949.

Mindell JA, Goldberg R, Fry JM. Treatment of a circadian rhythm disorder in a blind 2 year old child. J Visual Impair Blind 1996; 90:162-166.

Goldman MD, Matthieu M, Montely JM, Goldberg R, Fry JM, Bernard JL, Sartene R. Inspiratory fall in systolic pressure in normal and asthmatic subjects. AJRCCM 1995; 151:743-750.

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1. Affiliation: 1997-1998 Entry - Circadian, Neuroendocrine, and Sleep Disorders Section Harvard Medical School and Brigham & Women's Hospital

2. Name & Address: Charles A. Czeisler, Ph.D., M.D

Circadian, Neuroendocrine, and Sleep Disorders Medicine
Division of Endocrinology, Department of Medicine
Brigham & Women's Hospital/Harvard Medical School
221 Longwood Avenue, Boston, MA 02115

Phone: (617) 732-4013;
FAX: (617) 732-4015;
E-Mail: czeisler@tnp01.bwh.harvard.edu

3. Other Faculty:

Steven Amira, Ph.D.; Richard E. Kronauer, Ph.D.; Derk-Jan Dijk, Ph.D.; Joseph M. Ronda, M.S.; Larry Epstein, M.D.; Steven A. Shea, Ph.D.; Elizabeth B. Klerman, M.D., Ph.D.; John W. Winkelman, M.D., Ph.D.; David P. White, M.D.

4. Types Of Training Available:

Undergraduate: Research assistantships and internships & Nathaniel Kleitman Summer Fellowships.
Graduate: Research placements are available for graduate students and medical students.
Postdoctoral: There are postdoctoral research opportunities available.
5. Types Of Funding Available:

Undergraduate and graduate trainees are funded from research grants. Postdocs usually apply for fellowships from NIMH, NIA, and the NRC.

6. Number and Names Of Current Trainees:

Postdoctoral Fellows: : Christian Cajochen, Ph.D.; Sat Bir Khalsa, Ph.D.; Kenneth Wright, Ph.D. James K. Wyatt, Ph.D.
Predoctoral Fellows: Jeanne F. Duffy, Megan E. Jewett, David W. Rimmer, Angela Ritz, Jamie M. Zeitzer

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Diane B. Bovin, M.D., Ph.D. Assistant Professor McGill University
Derk-Jan Dijk, Ph.D. Assistant Professor Harvard Medical School, Brigham & Womens Hospital
Torsten Klein, M.D. Psychiatry Resident University of Frieburg, Germany
Elizabeth Klerman, M.D., Ph.D. Instructor   Harvard Medical School, Brigham & Women’s Hospital
Heinz Martens, M.D., Medical Director   McNight Laboratories, Germany
William S. Mezzanotte, M.D. Physician   Private Practice
David Neri, Ph.D. Research Psychologist Naval Health Research Center, San Diego
Rainer Popovic, M.D. Assistant Professor University of Vienna
Theresa Shanahan, M.D. Pediatric Resident Tufts/New England Medical Center
Douglas J. Tangel, M.D. Clinical Assistant Professor University of Colorado
Alan E. Ward   Medical Student   University of Massachusetts, Worcester
John R. Wheatley, M.D., Ph.D. Associate Professor University of Sydney-Westmeade

8. Primary Research Focus:

+ Physiology of the human circadian pacemaker and its entrainment by light
+ Temporal dynamics in neuroendocrine systems
+ Homeostatic and circadian factors in the regulation of sleep and alertness
+ Application of circadian physiology to occupational medicine/health policy
+ Sleep disorders medicine
+ Control of the Pharyngeal musculature during wakefulness and sleep/Pathophysiology of Sleep Apnea
+ Control of ventilation durig wakefulness and sleep

9. Technical Capabilities Of The Lab:

* 5 temporal isolation suites in the Intensive Physiological Monitoring Unit of the GCRC (Inpatient studies)
* 8 bedroom laboratory (six are complete time-isolation suites for circadian studies)
* 4 bedroom Sleep Disorders Clinic (all time-isolation shuites)
* 9 beds on general GCRC equipped for sleep records, including 5 equipped for intensive respiratory monitoring
* 16 Digital EEG acquisition systems, {7 Healthdyne (Alice III) and 9 Nicolet (Ultrasom) systems}
* 4 standard polygraphs (Nihon-Kohden 10 and 21 channel)
* 6 25-Channel Vitaport-2 digital ambulatory sleep recorders
* 4 laser printers, 1 flatbed scanner, 3 CD-R and 3 optical disk archival systems
* Laboratory and ambulatory core body temperature and light monitors, 35 Wrist actigraphs (AMI/PCD)

10. Primary Training Focus:

Undergraduate Students (honors thesis, summer fellowship)
Graduate Students (masters thesis and dissertation)
Postdoctoral Fellows (clinical and research training)

11. Other Training Opportunities:

Brigham and Women’s Hospital Sleep Disorders Center (David P. White, M.D.)
Circadian rhythms in unicellular organisms (J. Woody Hastings, Ph.D.)
Molecular approaches to the circadian pacemaker (Charles Weitz, M.D., Ph.D.)
Molecular approaches to the circadian pacemaker and pineal gland (Steve Reppert, M.D.)
Neurophysiology Laboratory, Massachusetts Mental Health Center (J. Allan Hobson, M.D.)
Neurophysiology of sleep amd arousal (Cliff Saper, Ph.D.)
Respiratory and sleep research, Harvard School of Public Health (Steven A. Shea, Ph.D.)
Sleep disorders medicine and respiratory motor control and sleep (David P. White, M.D.)
Statistics Research Laboratory (Emery N. Brown, M.D., Ph.D.)
Vision and visual attention laboratory (Jeremy M. Wolf, Ph.D.)

12. Representative Publications For Last Five Years:

Boivin DB, Czeisler CA, Dijk D-J, Duffy JF, Folkard S, Minors DS, Totterdell P, Waterhouse JM. Complex interaction of the
sleep-wake cycle and circadian phase modulates mood in health people. ArchGen Psychiatry 1997;54:145-152.

Brown EN, Choe Y, Shanahan TL, Czeisler CA. A methematical model of diurnal variations in human plasma melatonin levels.
Am J Physiology 1997; in press.

El-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. Parathyroid hormone circadian rhythm is truly
endogenous. J Clin Endocrinol Metab 1997; 82:281-286.

Mezzanotte WS, Tangel DJ, and White DP. Waking and sleeping upper airway muscle activity in apnea patients versus normal
controls. Am J Respir Crit Care Med 1996; 153:1880-1887.

Douse MA, and White DP. Serotonergic effects on hypoglossal neural activity and reflex responses. Brain Research 1996;
726:213-232.

Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Dose-response relationships for resetting of human circadian clock by light.
Nature 1996; 358: 540-542.

Duffy JF, Kronauer RE, Czeisler CA. Phase-shifting human circadian rhythms: Influence of sleep timing, social contact and
light exposure. J Physiol (London) 1996; 495.1:289-297.

Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. Simulations of effect of light on human circadian pacemaker: implications for
assessment of intrinsic period. Am J Physiology 1996;270:R271-R282, in press.

Richardson GS, Wyatt JK, Sullivan JP, Orav EJ, Ward AE, Wolf MA, Czeisler CA. Objective assessment of sleep and
alertness in medical house staff and the impact of protected time for sleep. Sleep 1996; 19: 718-726.

Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo III JF. Bright light suppression of
melatonin levels in some blind patients lacking conscious light perception. N Engl J Med 1995;332:6-11.

Dijk DJ and Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neuroscience 1995;15:3526-3538.

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1. Affiliation: 1997-1998 Entry - Brown University and Brown University School of Medicine

2. Name & Address: Mary A. Carskadon, Ph.D

Brown University - Department of Psychiatry
E.P. Bradley Hospital
1011 Veterans Memorial Parkway
East Providence, RI 02915

Phone: (401) 421-9440
FAX: (401) 453-3578;
E-Mail: Mary_Carskadon@Brown.edu

3. Other Faculty: Christine Acebo, Ph.D., Susan Labyak, Ph.D., Mark Bauer, M.D., Richard P. Millman, M.D., Judy Owens-Stively, M.D., Tony Spirito, Ph.D., Ronald Seifer, Ph.D., Barbara Tate, Ph.D.

4. Types Of Training Available:

* Research placement for Behavioral Medicine track of Brown University Psychology Internship Consortium
* Predoctoral program in Psychology
* Postdoctoral Fellowship in Child Mental Health
* Sleep and Chronobiology Summer Life Sciences Research Apprenticeship Award

5. Types Of Funding Available: NIMH T32 Training grant in Child Mental Health; Departmental, Sleep and Chronobiology Summer Life Sciences Research Apprenticeship Award

6. Names Of Current Trainees:

Graduate Student: Carol Leotta
Visiting Graduate Student: Fernando Louzada (1/20/97-6/20/97)
Postdocs: Pamela Thacher, Ph.D., Helen Bearpark, Ph.D.

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Predoctoral
    J. Spencer 1990 Predoctoral student, Indiana University
    J. Bortz 1991 No information Provided
    J. Wicks 1991 LLD student, Georgetown University
    K. Sharkey 1991 Predoctoral (MD/Ph.D), Rush School of Medicine
    M. Perlis 1993 Assistant Professor, Department of Psychiatry, Univ. of Rochester, NY
    P. Thacher 1993 Postdoctoral fellow, Brown University
    J. Wyatt 1995 Postdoctoral fellow, Harvard University
    C. Brown 1995 Medical School Student, Case Western Reserve
    S. Ashman 1995 Research Assistant, NIMH Intramural
    G. Scharoun 1995 Graduate Student, University of Vermont
    S. Aucello 1996 Research Assistant, NIMH Intramural

Postdoctoral
    A. Sadeh 1990 Assistant Professor, Tel Aviv University
    H. Sachs 1993 Attending Child Psychiatrist, E.P. Bradley Hospital
    L. Mercier 1992 Psychologist, Private Practice
    O. Chishinski 1995 Researcher, Technion, Israel

8. Primary Research Focus Of Laboratory:

Sleep, Sleepiness, Circadian Rhythms, Behavior and Development

9. Technical Capabilities Of The Lab:

+ 4 bed lab with Grass & Nicolet Ultrason
+ Ambulatory: Oxford Medilog; AMI Actigraphy
+ Animal facility for small mammal circadian rhythms and sleep (Tate)

10. Primary Training Focus: Sleep, sleepiness, and circadian rhythms in children and adolescents

11. Other Training Opportunities:

* Animal models: molecular neurobiology and sleep and circadian physiology (Tate)
* Full service sleep disorders center (Millman), including anxiety/insomnia (Posner) and pediatrics (Owens-Stively, Spirito)

12. Representative Publications For Last Five Years:

Sadeh, A., Acebo, C., Seifer, R., Carskadon, M.A. Activity-based assessment of sleep-wake patterns during the first year of life. Infant Behavior and Development 18(3):329-337, 1995.

Carskadon, M.A. & Sharkey, K.M. Societal impact of sleep disorders and insufficient sleep. J. Soc. Obstet. Gyn. (Can.) September:5-9,1993

Sadeh, A., Sharkey, K., Carskadon, M.A. Activity-based sleep-wake identification: an empirical test of methodological issues. Sleep 17(3):201-207, 1994.

Carskadon, M.A., Vieira, C., Acebo, C. Association between puberty and delayed phase preference. Sleep 16(3):
258-262, 1993.

Carskadon, M.A. & Dement, W.C. Multiple sleep latency tests during the constant routing. Sleep 15:396-399, 1992.

Carskadon, M.A. & Acebo, C. A self-administered rating scale for pubertal development. J. Adolesc. Health Care 14:
190-195, 1993.

Acebo, C., Millman, R., Rosenberg, C., Cavallo, A., Carskadon, M.A. Sleep, breathing, and cephalometrics in older children and young adults: Part I - normative values. Chest, 109(3):664-672, 1996.

Millman, R., Acebo, C., Rosenberg, C., Carskadon, M.A. Sleep, breathing, and cephalometrics in older children and young adults: Part II - effects of nasal occlusion. Chest, 109(3):673-679, 1996.

Carskadon, M.A., Richardson, G., Tate, B., Acebo, C., Seifer, R. Circadian parameters in adolescence: preliminary results using the "long nights protocol". Sleep Research, 25:545, 1996.

Carskadon, M.A., Acebo, C., Richardson, G., Tate, B., Seifer, R. Entrainment of sleep and dim-light salivary melatonin onset (DLSMO) in young adolescents using a fixed schedule. Sleep Research, 25:544, 1996.

Carskadon, M.A., Bearpark, H.M., Sharkey, K.M., Millman, R.P., Rosenberg, C., Cavallo, A., Carlisle, C., Acebo, C. Effects of menopause and nasal occlusion on breathing during sleep. American J. Respiratory and Critical Care Medicine, in press.

Carskadon, M.A., Acebo, C., Richardson, G.S., Tate, B.A., Seifer, R. An approach to studying circadian rhythms of adolescent humans. Journal of Biological Rhythms, in press.

Carskadon, M.A., Acebo, C., Wolfson, A.R., Tzischinsky, O., & Darley, C. REM sleep on MSLTs in high school students is related to circadian phase. Sleep Research, 1997.

Carskadon, M.A., Acebo, C., Tate, B.A., & Richardson, G.S. MSLT during forced desynchrony in two adolescents. Sleep
Research, 1997.

Carskadon, M.A., & Acebo, C. Historical view of high school start time: Preliminary results. Sleep Research, 1997.

Acebo, C., & Carskadon, M.A. Relations among self-reported sleep patterns, health, and injuries in adolescents. Sleep
Research, 1997.

Acebo, C., & Carskadon, M.A. Reliability of actigraph measures in children and adolescents. Sleep Research, 1997.

Leotta, C., Carskadon, M.A., Acebo, C., Seifer, R., & Quinn, B. Effects of acute sleep restriction on affective response in
adolescents: Preliminary results. Sleep Research, 1997.

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1. Affiliation: 1996-1997 Entry - Brown Medical School, Department of Psychiatry Sleep Disorders Center (Rhode Island Hospital)

2. Name & Address: Donn A. Posner

Southside Medical Center
120 Dudley Street Suite 104
Providence, RI 02905

Phone: (401) 444-8355;
FAX: (401) 444-6374

3. Other Faculty::

Mary Carskadon (Sleep Research Laboratory, Bradley Hospital), Richard Millman (Rhode Island Hospital, Pulmonary Medicine), Naome Kramer (Rhode Island Hospital, Pulmonary Medicine), Anthony Spirito (Rhode Island Hospital, Child and Family Psychiatry), Judith Owens-Stively (Rhode Island Hospital, Pediatrics).

4. Types Of Training Available:

The Insomnia Clinic is part of the Sleep Disorders Center at Rhode Island Hospital is a member of a consortium of hospitals that comprimise the training sites for Brown Medical School. The medical school offers a clinical psychology intership which is broken down into four tracks consisting of adult, child and family, neuropsychology, and behvioral medicine. The Sleep Disorders Rotations is one of four rotationsoffered in the Behavioral Medicine track. In addition to extensive work in the outpatient treatment of insomnia and other sleep disorders in both adult and child populations, the rotation offers training in the cognitive behavioral treatment of anxiety disorders as they relate to medical illness, as well as general anxiety disorders. Clinical psychology interns do a four-month rotation in this Sleep Disorders and Anxiety Disorders Clinic under the primary supervision of myself. Interns are also provided with protected research time which may be spent with Dr. Carskadon.

*There are occasionally post-doctoral clinical opportunities available. There is also the possibility of a post-doctoral research opportunity with Mary Carskadon, Ph.D. who runs a separate research sleep lab through Bradley Hospital, another one of the members of the consortium.

5. Types Of Funding Available:

All clinical psychology interns are offered a package that commits to one year of funding and benefits for the internship year.

6. Number and Names Of Current Trainees: None Currently

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Michael L. Perlis, PhD Asst. Professor Dept. of Psychiatry, Univ. of Rochester
James K. Wyatt, PhD Research Fellow Sleep & Chronobiology, Harvard University
Pamela Thacher, PhD Research Fellow Sleep Research Laboratory, Brown University

8. Primary Research Focus Of Laboratory : n/a

9. Technical Capabilities Of The Lab: n/a

10. Primary Training Focus: Cognitive/Behavioral treatment of sleep and anxiety disorders.

11. Other Training Opportunities: See #4.

12. Representative Publications For Last Five Years: n/a

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1. Affiliation: 1996-1997 Entry - City College of New York, Department of Psychology Experimental Cognition Doctoral Program, City University of New York.

2. Name & Address: Arthur J. Spielman, Ph.D.

The City College of New York - Department of Psychology
138 Street & Covent Avenue
New York, NY 10031

Phone: (212) 650-5397;
FAX: (212) 650-5724

3. Other Faculty: John Antrobus, Ph.D., Steve Ellman, Ph.D., William Fishbein, Ph.D., Joao Nunes, M.D. (CUNY Medical School), Paul B. Glovinsky, Ph.D. (Adjunct).

4. Type Of Training Available:

* Undergraduate course Sleep, dreams and laboratory techniques

* Graduate didactic courses Sleep Research, Clinical Sleep Disorders, Insomnia Disorders, Disorders of Excessive Somnolence, Sleep Disorders Special Topics, Dreaming

* Graduate practica and externships Sleep Lab Techniques, Evaluation of Patients with Sleep Disorders, Treatment of Patient with Sleep Disorders, Externship (at affiliated institutions Sleep Disorders Centers at Danbury Hospital, NYU Medical Center, St. Luke'sRoosevelt Hospital Ctr )

* Graduate students are enrolled in either the (1) Masters program, (2) Clinical Psychology doctoral program, or (3) Experimental Cognition doctoral program. In addition, there is subspecialization available in the Clinical Psychology of Neurobehavioral Disorders (a joint track of the Clinical and Cognition programs that combines research and clinical training).

5. Types Of Funding Available:

The Departments of Psychology of the City College and the City University of New York offer financial support via tuition stipends, fellowships, teaching assistants and workstudy.

6. Number and Name Of Current Trainees:

5 undergraduates Sonia Vilgorin, Damond Fauconer, Suzy Kim, Matt Ebben, Dorothy Mills

3 masters Freddy Zizi, Renata Felsner, Michelle Wagreich

12 doctoral Mitchell Rubinstein, Rochelle Zozula, Jessica Mitchell, Jihad Saoud, Stuart Cantor, Santaro Ashizawa, ChienMing Yang, Hans Von Gizycki, Girardin JeanLouis, Maryellen Jilnicki, TaeJoon Uhm, Anthony Lequerica

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Lauren LipshutzBroch, Ph.D. Director, Sleep Disorders Center, Danbury Hospital, Danbury, CT
Suzanne Woodward, Ph.D. Assistant Clinical Professor, Wayne State University, Detroit, MI
Michael Anderson, Ph.D. Assistant Director, St. Luke's Sleep Disorders Center, Kansas City, MO
Lauren Caruso, Ph.D. Assistant Professor of Medicine (pending), New York Medical College, NY
Paul Saskin, Ph.D. Clinical Director, Sleep Disorders Center, Sunrise Hospital Las Vegas
Mark Pressman, Ph.D. Associate Director, Sleep Disorders Center, Lankenau Hospital,
Clinical Associate Professor, Jefferson Medical College, Philadelphia, PA

8. Primary Research Focus Of Laboratory:

+ Nature of insomnia
+ Behavioral treatments of insomnia
+ Determinants of daytime sleepiness
+ Functions of REM sleep

9. Technical Capabilities Of The Lab:

* Three bedrooms sleep disorders research lab with 3 Grass model 7D polygraphs
* Evoked potentials
* Fully equipted animal laboratory with 2 Grass polygraphs

10. Primary Training Focus: Clinical sleep disorders and neuropsychology

11. Other Training Opportunities:

Sleep Disorders Centers:
Danbury Hospital (Drs. Lauren Broch and Arthur Koch)
NYU Medical Center (Drs. David Rapoport and Joyce Walsleben)
St. Luke's Roosevelt Medical Center (Dr. Gary Zammitt)
NJ Medicine and Dentistry (Dr. Ray Rosen)
Montefiore Medical Center (Dr. Michael Thorpy)

Others:
Alzheimer's Center, NYU Medical Center (Drs. Mony DeLeon and Steve Ferris)
Dept of Geriatrics, Mt Sinai Medical Center (staff) and neuropsychology programs

12. Representative Publications For Last Five Years:

Spielman, A.J. and Glovinsky, P.B. (in press). The Evaluation and Differential Diagnosis of Insomnia. Chapter. In: Sleep and Biological Rhythms in Health and Sickness. M. Pressman and W. Orr (eds), 55 mscrpt pages. American Psychological Association.

Spielman, A.J. and Glovinsky, P. B. (1991). The varied nature of insomnia. Chapter in: Case studies in insomnia. P. Hauri (Ed), 115. Plenum, NY.

Glovinsky, P.B. and Spielman, A.J. (1991). Sleep restriction therapy. Chapter in: Case studies in insomnia. P. Hauri (Ed), 4963. Plenum, NY.

Ellman, S.J., Spielman, A.J., and Lipschutz, L. (1991). REM Update. Chapter in: The Mind in Sleep. 329369, 369376. second edition, S. J. Ellman and J. A. Antrobus (eds.), Erlbaum Associates, NJ.

Spielman, A.J. and Herrera,C. (1991). Sleep disorders. Chapter in: The Mind in Sleep. 2580. S. J. Ellman and J. A. Antrobus (eds.), Erlbaum Associates, NJ.

Woodward, S., Tauber, E.S., Spielman, A.J., and Thorpy, M.J. (1990). The effects of otolithic vestibular stimulation on sleep. Sleep, 13(6), 533537.

Glovinsky, P.B., Spielman, A.J., Carroll, P., Weinstein, L., and Ellman, S.J. (1990). Sleepiness and REM recurrence: The effects of Stage 2 and REM sleep awakenings. Psychophysiology, 27(5), 552559.

- 6 -

1. Affiliation: 1997-1998 Entry - Sleep Disorders Institute, St. Luke's/Roosevelt Hospital Center, Columbia University - College of Physicians & Surgeons

2. Name & Address: Gary K. Zammit, Ph.D.

Sleep Disorders Institute
St. Lukes/Roosevelt Hospital Center
Amsterdam Avenue & 114th Street
New York, NY 10025

Phone: (212) 523-1700;
FAX: (212) 523-1704

3. Other Faculty:

Stephen Lund, M.D. (Psychiatry), Joseph Ghassibi, M.D. (Pulmonary Medicine), Zia Ahmed, M.D. (Neurology), Kathleen Rice, Ph.D. (Biofeedback), and Ronald Urioste, Ph.D. (Neuroscience Research) are the key staff of the Institute's clinical/research group. Norma Braun, M.D. (Pulmonary Medicine), Carl Braun, M.D. (Neurology), F. Xavier Pi-Sunyer, M.D. (Endocrinology, Diabetes, & Metabolism), Yosef Krespi, M.D. & Stephen Pearlman, M.D. (Otolaryngology), Darrick Antell, M.D., D.D.S., (Maxillofacial Surgery), Nancy Aronoff (Nutrition) are regular consultants.

4. Type Of Training Available:

Undergraduate course: The Psychobiology of Sleep. Summer course offered intermittently at Columbia University.

Clinical psychology externship: Provides a 1/2-time six-month externship for graduate students in clinical psychology.

Elective rotation for residents: Provides a 6 - 12 month elective rotation for fourth-year residents in psychiatry or other primary specialties who wish to pursue a sub-specialty in sleep medicine.

Elective rotation for pulmonary fellows: Provides a 1-2 month elective rotation for pulmonary physicians who wish to develop expertise in the evaluation and treatment of sleep-related breathing disorders.

Fellowship in sleep medicine: Provides a full-time 1 year fellowship for physicians or Ph.D. trainees who wish to pursue a career in sleep medicine.

Course in polysomnography and sleep medicine: Provides an intensive 1-week training experience for physicians and polysomnographic technologists who are new to the field of sleep medicine and who wish to acquire the basic clinical and technical skills required to function in a sleep disorders center.

5. Types Of Training Available:

Funding is available for full time fellows. No funds are available for externs, residents, or pulmonary fellows.

6. Number and Names Of Current Trainees:

One psychology extern (Ms. Jessica Mitchel). Multiple pulmonary fellows.

7. Students Who Have Completed Training In The Past Five Years:

More than 50 students have obtained training in sleep medicine at the Sleep Disorders Institute in the past three years: These include 30 pulmonary fellows, four psychiatry residents, one psychiatry fellow, one otolaryngology fellow, and four psychology trainees.

8. Primary Research Focus Of Laboratory:

+ Pharmacologic treatment of insomnia
+ Behavioral treatment of insomnia
+ Food intake, nutrition, and sleep
+ Obesity and sleep
+ Energy regulation and sleep

9. Technical Capabilities Of Lab:

* Three bedroom clinical recording facility with three Grass model 78 polygraphs interfaced and two Nicolet Ultrasom systems.
* One bedroom research laboratory with equipment for recording polysomnographic activity, human metabolic rate, and core and surface temperatures.
* Wet lab space
* Computerized biofeedback.
* SPSS. SAS.

10. Primary Training Focus: Pulmonary physicians, ENT physicians

11. Other Training Opportunities: F. Xavier Pi-Sunyer, M.D, - Endocrinology, Diabetes, and Metabolism

12. Representative Publications For Last Five Years:

Zammit, G. K., Kolevzon, A., Fauci, M., Shindledecker, R., & Ackerman, S. H. (1995). Postprandial Sleep in Healthy Men. Sleep, 18, 229-231.

Zammit, G. K., Lund, S., & Ghassibi, J. (1994). Clinical polysomnography in the evaluation of snoring and sleep-related breathing disorders. Operative Techniques in Otolaryngology Head and Neck Surgery, 5, 221-227.

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1. Affiliation: 1995-1996 Entry - University of Connecticut, Department of Psychology, Storrs, CT Ergonomics Laboratory, Grad. Program, Industrial and Organizational Psychology

2. Name & Address: Donald I. Tepas

University of Connecticut, Department of Psychology
406 Babbidge Road Box U-20
Storrs, CT 06269-1020

Phone: (203) 486-5928;
FAX: (203) 486-2760;
E-Mail: tepas@uconnvm.uconn.edu

3. Other Faculty:: In Industrial and Organizational Psychology, the full-time faculty include: Janet Barnes-Farrell, Robert A. Henning, R. James Holzworth, and Steven Mellor. The Psychology Department has around 40 full-time faculty.

4. Types Of Training Available:

The Ergonomics Laboratory is one of the few places in the U.S. offering graduate study in psychology with a focus on the occupational safety and health aspectsof shiftwork, work schedules, and sleep. It is part of the graduate program in Industrial
and Organizational Psychology. The major focus of this program is research methodology and the application of these skills to the problems of business, governemnt and industry. This program is designed for full-time graduate students seeking the Ph.D. Admission is quite competitive, and it takes 4 to 5 years to finish the program. One of these years is a full-time internship in business, government, or industry. Some examples of Ergonomics Laboratory internship sites Ford Motor Company, IBM Corporation, Institute of Occupational Health (Finland), National Aeronautics & Space Administration, Liberty Mutual Insurance Research Center, and NYNEX.

5. Types Of Funding Available:

One must be accepted as a full-time graduate student in this Ph.D. program to obtain funding. During the ten year history of this program, all requests for graduate assistantships have been honored, and we expect this to continue. In most cases, these assistantships require about 9 hours of work per week. All assistantships carry with them full tuition waiver and free medical/dental health insurance. Most students spend their third year on Internship, with the employer paying them a salary.

6. Number and Names Of Current Trainees: (5) Graduate students are currently working on their graduate degrees in the Ergonomics Laboratory. They are: S. Aloteras-Webb, M. Coplen, L.B. Herbert, M. Paley, and S. Popkin.

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Robert P. Mahan Associate Professor Dept. of Psychology, University of Georgia
Antonio C. Carvalhais Research Scientist U.S. Coast Guard R. & D. Center, Connecticut
Debra K. Dekker Human Factors Engineer Comsis Corporation, Maryland

8. Primary Research Focus Of Laboratory :

+ Sleep as it relates to occupational safety and health aspects of night and shiftwork
+ Work/rest schedules as they relate to transpiration safety problems and driver sleepiness
+ Human performance, health and safety problems associated with automation
+ Development of new methods to assess sleep fatigue, boredom, and workload

9. Technical Capabilities Of The Lab:

* Six bedroom sleep research lab
* Extensive computer capabilities for automated sleep staging and analysis
* Six ambulatory monitoring systems
* 3 wrist actigraphs

10. Primary Training Focus: No information given.

11. Other Training Opportunities:

Many of our research projects involve collecting data in the field at various workplaces, such as factories and government installations. Also note the required Internship, listed earlier.

12. Representative Publications For Last Five Years:

Paley, M.J. and Tepas, D.I. (1994). Do smart ightway + intelligent vehicles = new kinds of human factors display problems? Society of Photo-Optical Instrumentation Engineers Proceedings, 2344: 299-206.

Tepas, D.I. (1994). Technological innovation and the management of alertness and fatigue in the workplace. Human Performance, 7:165-180.

Paley, M.J. and Tepas, D.I. (1994). Fatigue and the shiftworker: firefighters working on a rotating shift schedule. Human Factors, 36:269-284.

Tepas, D.I., Duchon, J.C. and Gerston, A.H. (1993). Shiftwork and the older worker. Experimental Aging Research, 19:295-320.

Dekker, D.K., Paley, M.J. and Tepas, D.I. (1993). Locomotive engineers and their spouses: Coffee consumption, mood, and sleep reports. Ergonomics, 36: 233-238.

Tepas, D.I. (1993). Educational programs for shiftworkers, families, and prospective shiftworkers. Ergonomics, 36:199-2009.

Tepas, D.I. and Paley, M.J. (1992). Managing alertness and fatigue in advances intelligent vehicle highway systems. Surface Transportation and the Information Age, 2:785-789.

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1. Affiliation: 1996-1997 Entry - Department of Psychiatry, Laboratory of Human Chronobiology, Cornell University Medical College

2. Name & Address: Scott S. Campbell, Ph.D.

Institute of Chronobiology
New York Hospital/Cornell Medical Center
21 Bloomingdale Road
White Plains, NY 10605

Phone: (914) 997-5924;
FAX: (914) 682-1536;
E-Mail: sscampb@med.cornell.edu

3. Other Faculty: George Alexopoulos, M.D. (Psychiatry), Daniel Carpenter, Ph.D. (Psychology), Tatzu Kakuma, Ph.D. (Psychiatry), Gregory Brown, Ph.D.(Psychiatry), Joe Gertner, M.D. (Pediatrics), Daniel Wagner, M.D. (Psychiatry/Neurology), Robert Young, M.D. (Psychiatry)

4. Type Of Training Available:

* Undergraduate Summer Research Program: Undergraduate students are employed as research technicians. Trainees during summer months. Comprehensive training in sleep/chronobiological research methods.
* Graduate Research Opportunuities: Ph.D. students (typically enrolled in programs at other Universities in the
Greater New York Area) conduct dissertation projects under the supervision of Dr. Campbell and LHC staff.
* Postdoctoral Research Fellowships: recent Ph.D.'s or A.B.D.'s join the LHC for 13 years. This program strongly encourages fellows to conduct independent research projects that will lead to firstauthored publications and acquisition of extramural funding.
* Clinical Research Training Program: M.D.'s in Geriatric Psychiatry undertake chronobiological research training/projects
focusing on aspects of geriatric mood disorders.

5. Types Of Funding Available:

Undergraduate Summer Program: Trainees receive an hourly wage.
Graduate Program: The LHC provides infrastructure support (lab supplies/technical support) for completion of candidate's research project. Occasionally, a stipend is available.
Postdoctoral Fellowships: Salary and infrastructure support are provided, and there are internal funding sources to support additional research projects.
Clinical Research Program: The LHC provides infrastructure support (lab spplies/technical support) for completion of candidate's research project.

6. Number and Names Of Current Trainees:

Summer Program ('95): We will support 5 undergraduate trainees this year.
Graduate Program: None currently
Postdoctoral Fellowship Program: Patricia J. Murphy, A.B.D.

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Drew Dawson, Ph.D. Director, Sleep/Circadian Rhythms Lab Queen Elizabeth Hospital, Univer. of Adelaide, Adelaide, South Australia

Michael Anderson, Ph.D., ACP Assistant Director Sleep Disorders Center, Romaker & Associates Kansas City, Missouri

Jennifer Peszka, B.S. Graduate Student Department of Psychology, Univ. of Southern Mississippi, Hattiesburg, MS

8. Primary Research Focus Of Laboratory:

We use longterm, electrophysiological recording techniques to study behavioral and physiological components of the circadian system and their interrelationships. The practical goal of the research is to develop nonpharmacological approaches to improving sleep, alertness and performance in sleep and circadian rhythms disturbed populations, including psychiatric populations and especially the elderly. At the level of basic science, the aim is to clarify the differential contributions of environmental, behavioral and physiological factors in the regulation of biological rhythms.

9. Technical Capabilities Of The Lab:

Stateoftheart data acquisition capabilities include computerbased, amubulatory/telemetric polysomnography, actigraphy, ambulatory body core temperature acquisition, computer assisted quantitative EEG analysis, computerbased cognitive and psychomotor performance. We have 4 selfcontained apartments for timefree studies, as well as 4 bedrooms for shortterm studies.

10. Primary Training Focus:

Our primary training focus is on human chronobiological research methods. Our primary goal is to provide an atmosphere that will foster innovative and independent research by trainees.

11. Other Training Opportunities: No information provided.

12. Representative Publications For Last Five Years:

Dawson D and Campbell SS: Bright light treatments: Are we keeping our subjects in the dark? Sleep 13(3): 267271, 1990.

Campbell SS and Dawson D: Enhancement of nighttime alertness and performance with bright ambient light. Physiology and Behavior 48: 317320, 1990.

Dawson D and Campbell SS: Timed exposure to bright light improves sleep and alertness during simulated night shifts.

Sleep 14(6): 511516, 1991.

Campbell SS and Dawson D: Aging young sleep: A test of the phase advance hypothesis of sleep disturbance in the elderly. Journal of Sleep Research 1(3): 205210, 1992.

Campbell SS, Dawson D and Anderson MW: Alleviation of sleep maintenance insomnia with timed exposure to bright light. Journal American Geriatrics Society 41:829836, 1993.

Campbell SS, Dawson D and Zulley J: When the human circadian system is caught napping: Evidence for endogenous rhythms close to twentyfour hours. Sleep 16(7): 638640, 1993.

Campbell SS and Broughton RJ: Declining body temperature prior to sleep initiation: Fluffing the physiological pillow? Chronobiology International 11(2): 126131, 1994.

Murphy PJ, Boothroyd CE, Campbell, SS: A physiologic trigger for sleep onset: Is a rapid decline in body temperature the smoking gun ? Sleep Research 26: 565, 1996.

Murphy PJ, Boothroyd CE, Campbell, SS: Why George Burns could use bright light treatment: Performnace enhancement following light treatment of sleep maintenance insomnia. Sleep Research 26:566, 1996.

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1. Affiliation: 1997-1998 Entry - Sleep Disorders Center, Crozer-Chester Medical Center

2. Name & Address: Calvin R. Stafford, M.D.

One Medical Center Boulevard
Upland, PA 19013

Phone: (610) 447-2689
FAX: (610) 447-2918
E-Mail: StaffordC@Allegheny.Edu

3. Other Faculty: Wendell A. Grogan, M.D., Andrew J. Borson, Ph.D.

4. Types of Training Available: The Sleep Disorders Center provides a 4-month rotation during a standard clinical neurophysiology fellowship. Other blocks are 4 months of EEG and evoked potentials and 4 months of EMG.

5. Types Of Funding Available (Trainee Support): PGY5 salary for individual having completed an AMA approved neurology residency.

6. Types Of Funding (Laboratory Grants): None.

7. Number and Names Of Current Trainees: (1) Michael Baccoli, M.D.

8. Students Who Have Completed Training In The Past Five Years and Current Status: (5)

     1994 to 1995 Mark Woodward, M.D. Staff Neurologist, Trenton, NJ.
     1993 to 1994 Budha S. Chahil, M.D. Staff Neurologist, Bakersfield, CA.
     1993 to 1994 Fran Weiner, M.D. Staff Neurologist, New Jersey.
     1992 to 1993 Kathy Piston, M.D. Staff Neurologist, Altoona, PA.
     1991 to 1992 Thomas Mueller Staff Neurologist & Co-Director Sleep Disorders Center, Wilmington, DE.

9. Primary Research Focus Of Laboratory: This is a clinical facility.

10. Technical Capabilities Of Laboratory: 4-bed clinical lab in conjunction with Department of Clinical Neurophysiology.

11. Primary Training Focus: Clinical care of patients with sleep disorders.

12. Other Training Opportunities:

The Sleep Disorders Center accommodates MDs and DOs who have completed residency training in pulmonary medicine, neurology or psychiatry for non-funded training on a part-time or short-block full-time basis to gather experience for careers in sleep medicine.

13. Representative Publications For Past Five Years: No information provided.

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1. Affiliation: 1996-1997 Entry - Department of Psychology , University of Delaware

2. Name & Address: Evelyn Satinoff

Dept. of Psychology, University of Delaware
Newark, DE 19716

Phone: (302) 831-2271
FAX: (302) 831-3645
E-Mail satinoff@udel.edu

3. Other Faculty: No information provided

4. Type Of Training Available:

Graduate training: Graduate students working with me are generally part of the biopsychology division or they can be in the Neuroscience Program, through either Psychology or Biology.
Fellowships: Postdoctoral positions are also available, depending on funding.

5. Types Of Funding Available:

Graduate students admitted in the psychology department are guaranteed four years of support as long as they remain in good standing. The support may consist of a teaching or research assistantship, or a University Fellowship (the latter only for one year).

6. Number and Names Of Current Trainees: (2)

Graduate students: Cindy Xin
Postdoctoral fellows: Maciek Wachulec
Senior Scientist: Hideto Tanaka

7. Students Who Have Completed Training In The Past Five Years and Current Status:

1990 - Stephen Kent, PhD Asst. Professor, Dept. of Psychology La Trobe University
1995 - Hua Li, PhD. Postdoctoral Fellow VA Medical Center Gainesville, FL 32602

8. Primary Research Focus:

+ Disturbances in circadian rhythms with aging
+ Sleep and thermoregulation in aging rats
+ Fetal hypothalamic transplants in old rats and in rats with suprachiasmatic nuclear lesions
+ Fever and endotoxin tolerance

9. Technical Capabilities Of The Lab:

* Temperature telemetry
* Computer assisted data acquisition and analysis
* Computer analyzed scoring
* Immunocytochemistry
* Fetal grafting
* Stereotaxic surgery
* Various behavioral measures
* RIA for cortisol

10. Primary Training Focus: Basic neuroscience.

11. Other training opportunites:

The University of Delaware is conveniently located for collaborative research with scientists from Baltimore (Johns Hopkins) to Philadelphia (Penn, Temple, various hospitals.) The A. I. DuPont Institute is nearby, with its focus on children's ailments. There are several neurologists there interested in sleep research.

12. Representative Publications For Last Five Years:

Kent, S. and Satinoff, E. Influence of ambient temperature on sleep and body temperature after phentolamine in rats. Brain Res., 1990, 511:227 233.

Li, H. and Satinoff, E. Effects of para chlorophenylalanine on thermoregulation and sleep in rats. Brain Res., 1992, 569:46 56.

Satinoff, E. Temperature effects on sleep. In: M. Carskadon (Ed.) Encyclopedia of sleep and dreaming. New York: Mac Millan, 1993, pp. 613 614.

Satinoff, E. Li, H., Liu, C., McArthur, A., Medanic, M., Tcheng, T. and Gillette, M. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones? Amer. J. Physiol., 1993, 265:R1216 R1222.

Li, H. and Satinoff, E. Changes in circadian rhythms of body temperature and sleep in old rats. Amer. J. Physiol (RICP), 1995. 269:R208-R214.

Li, H. and Satinoff, E. Differences in sleep architecture between normal and ovariectomized rats. Amer. J. Physiol., accepted pending revision.

- 11 -

1. Affiliation: 1995-1996 - Harvard Medical School, Department of Psychiatry and McLean Sleep Disorders Center and Sleep Research Program

2. Name & Address: Cynthia M. Dorsey, Ph.D.

McLean Hospital
115 Mill Street
Belmont, MA 02178

Phone: (617) 855-3194
FAX: (617) 855-3823
E-Mail: dorsey@mclean.org

3. Other Faculty:

John Winkelman, M.D. (psychiatry), Scott Lukas, Ph.D. (pharmacology), Martin Teicher, M.D., Ph.D. (psychiatry), Andrew Satlin, M.D. (geriatrics), and Gary Richardson, M.D. (endocrinology), are research and/or clinical collaborators involved in the McLean Sleep Disorders Center.

4. Types Of Training Available: We are involved in training at most levels:

* Undergraduate: Research assistantships and internships.
* Graduate training: This is available, but we have had primarily psychology interns who have finished their graduate programs and who are involved in the laboratory during their interships at McLean. Clinical psychology interns in the Cognitive Behavior Therapy Internship at McLean can do 5-10 hour/wk year-long rotation at the Sleep Disorders Center.
* Postdoctoral opportunities: There are occasional postdoctoral research opportunities

5. Types Of Funding Available:

Limited at present. Clinical psychology interns in the Cognitive Behavior Therapy Internship at McLean are usually funded by stipend or fee-for-service and the SDC rotation constitutes part of this arrangement. Funding may be available for graduate students and research assistants in 1996-97. No funds are anticipated for postdoctoral fellowships for 1995-1996.

6. Number and Names Of Current Trainees: No information provided

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Sonia Gyan, Ph.D. Postdoctoral fellow Psychology Department, Lahey Clinic
Jennifer Taylor, Ph.D. Postdoctoral fellow Sleep Reserach Laboratory, E.P. Bradley Hospital
Thomas Hack, Ph.D. Postdoctoral fellow Department of Psychology, Toronto Hospital

8. Primary Research Focus Of Laboratory:

+ Behavioral treatment for insomnia
+ Sleep and aging
+ Pharmacology and sleep
+ Health, psychopathology, and sleep

9. Technical Capabilities Of The Lab:

* Four bedroom laboratory (clinical and research) with 3 polygraphs and videotaping capability
* 1-3 wrist actigraphs
* 1 temperature monitor (Mini Mitter core body temperature sensors and recorder)
* Extensive computer capabilities for automated sleep staging, power spectral analysis, and event-related potential research

10. Primary Training Focus:

Post-graduate training in sleep disorders medicine - diagnosis and treatment. Cognitive Behavior Therapy to address Insomnia.

11. Other Training Opportunities:

Cognitive Behavior Therapy Internship, McLean Hospital (Philip Levendusky, Ph.D.); Developmental Biopsychiatry Research, Development Psychopharmacology, McLean Hospital (Martin Teicher); Geriatric Psychiatry, Memory Diagnostic Clinic/Alzheimer (Andrew Satlin, M.D.); Neuropsychopharmacology Laboratory (Scott Lukas, Ph.D.).

12. Representative Publications For Last Five Years:

Dorsey, CM, Lukas SE, Teicher M, Satlin A. Passive body heating: A method for treating insomnia in the older adult insomniac. In preparation.

Keck PE Jr., Hudson JI, Dorsey CM, Matheson JK, Campbell PI. Increased eye movements and muscle tone during non-REM sleep in fluoxetine-associated insomnia. (Letter to the editor) Biological Psychiatry 1991; 29:618-619.

Dorsey CM, Cunningham SL, Richardson GS, Lukas SE, Winkelman JW. Effect of fluoxetine on sleep. Submitted for publication.

Cunningham, SL, Dorsey CM, Richarson GS, Winkelman JW, Lukas SE, Fortin MB. An objective marker for neuroleptic-induced akathisia: Preliminary measures of sensitivity and specificity. Submitted for publication.

Cunningham SL, Richardson GS, Dorsey CM. Polysomnographic features of akathisia syndrome in two patients. Sleep Research 1991;20.

Dorsey CM, Cunningham SL, Richardson GS, Lukas SE, Winkelman JW. Increased risk of periodic leg movements during sleep. Sleep Research 1992;21.

Dorsey CM, Cunningham SL, Lukas SE, Winkelman JW, Richardson GS, Jones K. Fluoxetine-induced eye movements during non-REM sleep. Sleep Research 1992;21.

Lukas SE, Dorsey CM, Meldelson JH, Mellow NK, Abdulali A, Fortin M, Abdulali S, Cunningham SL. Effects of buprenorphine treatment on the sleep of cocaine- and heroin-dependent subjects. Sleep Research 1992;21.

Winkelman JW, Dorsey CM, Cunningham SL, Lukas SE. Nocturnal binge eating: Sleep disorder or eating disorder? Sleep Research 1993;23.

Hack TF, Gyan SN, Cunningham SL, Ford AR, Winkelman JW, Dorsey CM. Relationship between subjective and objective measures of sleep latency in female PTSD patients with abuse histories. Sleep Research 1994;23.

Teicher MH, Glod CA, Ito Y, Dorsey CM. Independent evaluation of actigraph sleep-scoring algorithms. Sleep Research 1994;23.

Dorsey CM, Lukas SE, Satlin A, Rosenberg R. Degree of physical activity and perception of sleep quality among healthy elderly men and women. Sleep Research 1994;24.

Cunningham SL, Ellsworth SD, Winkelman JW, Dorsey CM, Ford A, Lukas SE. Compliance with nasal CPAP in psychiatric patients with obstructive sleep apnea. Sleep Research 1994;23.

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1. Affiliation: 1997-1998 Entry - Harvard Medical School

2. Name & Address: J. Allan Hobson

74 Fenwood Road
Boston, MA 02115

Phone: (617) 734-9645
FAX: (617) 734-7851

3. Other Faculty: James Quattroch, Robert Stickgold, Subimel Datta, Edward Schott, Lia Silvestri-Hobson

4. Types Of Training Available: Postdoctoral fellowship 2 years

5. Types Of Funding Available: Negotiable

6. Names Of Current Trainees: No information provided

7. Students Who Have Completed Training In The Past Five Years and Current Status: No information provided

8. Primary Research Focus Of Laboratory:

+ Neurobiology,
+ Cognitive Neuroscience

9. Technical Capabilities Of The Lab:

* Microelectrodes
* Microinjections

10. Primary Training Focus: Research

11. Other Training Opportunities:

This laboratory accepts undergraduates and master’s level thesis candidates. By special arrangement, doctoral thesis work can be done as well. Visiting scientists, medical students and other trainee co-workers are welcome on an ad hoc basis.

2. Representative Publications For Last Five Years: Hobson JA & Silvestri R (1997). Sleep Disorders. In: Encyclopedia of Neuroscience G. Adelman (Ed.) (In Press).

Hobson JA (1997). A Review of Trauma and Dreams, Deirdre Barrett (Ed.). Nature Medicine 3(2):243.

Hobson JA (1997). (An Essay for Scientific American Anniversary Book "A Busy Night"). Scientific American Books
(In Press),

Hobson JA (1997), Dreaming as delirium: A mental status analysis of our nightly madness. Revue Internationale de Psychopathologie (In Press),

Kahn D, Pace-Schott E, Hobson JA (1997). Consciousness in waking and dreaming: The roles of neuronal oscillation and neuromodulation in determining similarities and differences. Neuroscience 78:1-25.

Xie Z, Stickgold RA, Pace-Schott EF & Hobson JA (1996). Visual discrimination learning task increases REM sleep. Society for Neuroscience 22:915.

Stickgold RA, Xie Z & Hobson JA (1996). Quantification of rapid eye movements with the Nightcap. Sleep Research 25:534.

Stickgold RA & Hobson JA (1996). On-line vigilance monitoring with the Nightcap. Sleep Research 25:533.

Hobson JA (1996). Picturing sleep and dreaming. WFSRS Newsletter(SRO) (In Press).

Hobson JA (1996). The restless brain. Odyssey 2:24-31.

Verrier RL, Stone PH, Pace-Schott EF & Hobson JA (1996), Sleep-related cardiovascular risk: New home-based monitoring technology for improved diagnosis and therapy. In: Annals of Noninvasive Electrocardiology, S. Stern, A. Moss (Eds.)
(In Press).

Kahn D, Pace-Schott EF, & Hobson JA (1996). Consciousness in Waking and Dreaming: The roles of neuronal oscillation and neuromodulation in determining similarities and differences. Neuroscience (In Press).

Verrier RL, Muller JE & Hobson JA (1996). Sleep, dreams, and sudden death: The case for sleep as an autonomic street test for the heart. Cardiovascular Research 31:181-211.

Porte H, & Hobson JA (1996). Physical motion in dreams: One measure of three theories. Journal of Abnormal Psychology 105:329-335.

Nordby H, Hugdahl K, Stickgold RA, Kolbjorn S, Bronnick, & Hobson JA (1996). State dependent features of human cognition: Event-related potentials (ERP’s) to deviant auditory stimuli during sleep and waking. NeuroReport 1:1082-1086.

Leslie KR, Stickgold RA, DiZio P, Lackner J & Hobson JA (1996). The effect of nauseogenic optokinetic stimulation on daytime sleepiness. Archives Italiennes de Biologie (In Press).

Sutton JP, & Hobson JA (1996). State-dependent sequencing and learning. In: Computation in Neurons and Neural Systems. Frank Eeckman (Ed.) Boston: Kluwer Academic Publishers.

Stickgold R (1986). Sleep and rhythms. In: Physiology, Blakemore, C. (Ed.) London: Gower Medical Publishing (In Press).

Leslie KR, Stickgold RA, DiZio P, Lackner J, & Hobson JA (1996). Sleep and vestibular adaptation: Implications for function in microgravity. In: The Journal of Vestibular Research (In Press).

Hobson JA (1996). Sleep: Behavior and cellular mechanisms. Encyclopedia of Neuroscience, 2nd Edition.

Hobson JA (1996). Dreaming. Encyclopedia of Neuroscience, 2nd Edition.

Hobson JA & Silvestri R (1996). The restless brain: Disorders of sleep and dreaming. Odyssey 2:24-31.

Hobson JA (1996). Sleep pays attention. Healthline (In Press).

Hobson JA & Silvestri R (1996). Sleep and its disorders. In: The New Harvard Guide to Psychiatry. AM Nicholi (Ed.) (In Press).

Hobson JA (1996). How the brain goes out of its mind. Endeavour, Elsevier Science Ltd. 1:86-89.

Hobson JA (1996). Consciousness (Lessons for Anesthesia from Sleep Research). In: Anesthesia: Biologic Foundations, Biebuyck (Ed.) (In Press).

Hobson JA (1996). Consciousness as a state-dependent phenomenon. In: Scientific Approaches to the Question of Consciousness, Cohen, Schooler (Eds.) (In Press).

Hobson JA (1996). Conscious states of the brain-mind: In: The Neuropsychology of waking, sleeping and dreaming, In: Fundamental Neuroscience, RY Moore & EM Stricker (Eds.) (In Press).

Hobson JA (1996). Dreaming as Delirium: A mental status analysis of our nightly madness. Revue Internationale de Psychopathologie (Le Reve).

Stickgold RA, Neri DF, Pace-Schott EF, Juguilon A, Czeisler CA & Hobson JA (1995). Nightcap detection of decreased vigilance. Sleep Research 24:500.

Stickgold RA, Ritterhouse CD & Hobson JA (1995). Circadian and sleep effects on semantic priming, Presented at the 2nd Annual Meeting of the Cognitive Neuroscience Society. March 26, 1995 in San Francisco, CA.

Pace-Schott EF, Stickgold RA, Matheson JK & Hobson JA (1995). The Nightcap can detect features of restless legs syndrome, a REM-related parasomnia, and delayed sleep phase syndrome. Submitted for publication. Sleep Research 25:520.

Pace-Schott EF, Bennett EF, Fagioli Al, Stickgold RA, Komaroff AL & Hobson JA (1995). Nightcap comparison of nocturnal eyelid quiescence in chronic fatigue syndrome patients compared to normal controls. Sleep Research 24:487.

Hobson JA & Stickgold RA (1995). Sleep the beloved teacher? Current Biology 5:35-36.

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1. Affiliation: 1997-1998 Entry - Department of Psychiatry, Brockton/West Roxbury VAMC, Harvard Medical School

2. Name & Address: Robert W. McCarley, M.D.

Harvard Medical School - Department of Psychiatry
VA Medical Center
940 Belmont Street
Brockton, MA 02401

Phone: (508)-583-4500 x3367
FAX: (508)-580-0059
E-mail:Mccarley@warren.med.edu

3. Other Faculty:

Robert W. Greene, M.D., Ph.D., Donald Rainnie, M.D., Priyattam Shiromani, Ph.D., Robert Strecker, Ph.D.

4. Type Of Training Available: Post-Doctoral Fellowships

5. Types Of Funding Available: NIMH-National Multi-site Training Program, Veteran Administration Merit Award, Veteran Administration Research Center Grant

6. Grant Funding: NIMH Grant, Veteran Administration Merit Award and Veteran Administration Research Center Grant

7. Number and Names of Current Trainees: (6)
Mahesh Thakkar
Lilini Ramanathan
Xiangyang Li
Alette Bjorkum
Tarja Porkka-Heiskanen
Stephen Morairty

8. Students Who Have Completed Training In The Past Five Years and Current Status:

Mamuro Yanagihara, Ph.D., Associate Professor, Okayama Prefectural University -Junior College

Shigeyoshi Higo, Ph.D., Assistant Professor of Anatomy, Kumamoto University, Japan

Michael Bier, Ph.D., Researcher, Sepulveda VAMC, Sepulveda, CA

Jennifer Luebke, Ph.D., Assistant Professor in the Department of Psychiatry and in the Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA

David Stevens Heinrich-Heine- Universitate Dusseldorf, Germany

Hitoshi Imon, M.D,. Anaesthesiologist, Department of Anesthesiology and Resuscitology, Ehime University, Japan

Susanna Birnstiel, M.D., Post Doc Fellow, Department of Pharmacology, Loyola University Medical Center, Maywood, IL

Urs Gerber, M.D., Assistant Professor, Brain Research Institute, University Zurich, Germany

Heinz Grunze Klinikum de Albert-Ludwigs-Universitat

9. Primary Research Focus of Laboratory:

1) Rapid Eye Movement (REM) Sleep using both in vivo and in vitro physiological studies and cellular anatomical studies.
2) Recordings of neurons in the laterodorsal and pedunculopontine Tegmental (LDT/PPT) nuclei.
3) Other investigations will focus on the effector neurons for REM sleep phenomena in the mPRF. These investigations of the ubiquitous state of REM sleep will provide an insight into the basic mechanisms of its generation and so enable more rational treatment of disorders associated with REM abnormalities. These include the major mood disorders, the sleep disturbance of post-traumatic stress disorder, and narcolepsy.

10. Technical Capabilities of the Lab:
About 10,000 sq feet in adjacent one-story bldgs. dedicated to research. One complete laboratory installation for intracellular in vivo work, this includes a sound attenuated recording room with a complete Kopf apparatus for intracellular recording, an Inchworm electrode advancer, a high input impedance pre=am, 3 TEKTRONIX CROs 1 storage CRO for display, 5 grass stimulators, a Grass polygraph, a Honeywell 8 channel FM tape recorder, a Narishige electrode puller and other equipment. There is also an extracellular recording set-up that includes: recording cage, slip-ring cable, a Bak modular recording system (amplifiers, filters, window discriminators, a Grass 6 channel polygraph, 3 CROs, and a 32 channel tape recorder. For in vitro work with pontine brainstem slices, the in vitro laboratory includes three complete set-ups for slice work, each with a kinetic stimulator, 2 CROs for display, a Medical Systems Corp., pneumatic system for the puffer electrodes, a Gould strip chart recorder and a Nixon binocular microscope for observation. For morphological and anatomical investigations, a Nikon diaphot microscope equipped with a Kodak DCS digital camera is used to interface with a Pentium based computer running Adobe Photoshop for graphic manipulations. Images can be viewed and captured using both bright field and epifluorescence microscopy. Hard copy of processed images can be output into either an Epson Stylus color printer or onto a Lasergraphics LFR slide maker. Two Brown, Flaming electrode pullers are available.

Animal Facility, Photography Darkroom , and Histological Laboratory are also on site.

11. Primary Training Focus: Post-doc training in Neuroscience

12. Other Training Opportunities: Training on NIMH Merit Award

13. Representative Publications For Last Five Years:

McCarley RW, Greene RW, Rainnie D, Portas CM. Brain Stem Neuromodulation and REM Sleep. Sem. Neurosciences
1995; 7:341-354.

Sherin JE, Shiromani PJ, McCarley RW, and Saper CB. Activation of ventrolateral preoptic neurons during sleep. Science 1996; 271: 216-219.

Imon H, Ito K, Dauphin L, McCarley RW. Electri-cal stimulation of the cholinergic laterodorsal tegmental nu-cle-us elicits scopolamine-sensitive EPSPs in medial pon-tine reticular formation neu-rons. Neuroscience 1996; 74:393-401.

Grunze HCR, Rainnie DG, Hasselmo ME, Barkai E, Hearn Ef, McCarley RW and Greene RW. NMDA-dependent modulation of CA1 local circuit inhibition. J. Neuroscience 1996; 16:2034-2043.

Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-OH-DPAT in the dorsal raphe nucleus decreases serotonin release and increases REM sleep in the freely moving cat. J. Neurosci. 1996; 16: 2820-2828.

Shiromani PJ, Winston S, and McCarley RW. Pontine cholinergic neurons show Fos-like immunoreactivity associated with cholinergically-induced REM sleep. Molecular Brain Research 1996; 38: 77-84.

Stevens DR, Gerber U, McCarley RW, Greene RW. Glycine-mediated inhibitory postsynaptic potentials in the medial pontine reticular formation of the rat in vitro. Neuroscience 1996; 73:791-796.

Thakkar M, Portas CM, McCarley RW. Chronic low amplitude electrical stimulation of the laterodorsal tegmental nucleus of freely moving cats increases REM sleep. Brain Research 1996; 723: 223-227.

Portas CM, Thakkar M, Rainnie DG., Greene RW,. and McCarley, RW. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat. Neuroscience 1997; In Press.

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1. Affiliation: 1997-1998 Entry - Department of Psychology, The College of the Holy Cross

2. Name & Address: Amy R. Wolfson, Ph.D.

The College of the Holy Cross
Dept. of Psychology
Worcester, MA 01610

Phone: (508) 793-2219
FAX: (508) 793-3709
E-mail: wolfson@Holycross.edu

3. Other Faculty: No inofrmation provided.

4. Type Of Training Available: Undergraduate degree (B.A.) opportunity to major in psychology or biopsychology with research training in sleep and behavior.

5. Types Of Funding Available: Undergraduate research awards from Holy Cross (e.g., summer research assistantships; funding to attend conferences as an undergraduate, etc.)

6. Number and Names Of Current Trainees: (3) Student research assistants Jennifer Blume, James MacNutt, Tom Castiglione. (I have approximately 6-7 research assistants each year).

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Anna Tobia:    Graduate student in clinical psychology.       St. Louis University, St. Louis, MO
Amy Gorin:     Graduate student in clinical psychology.        SUNY, Stonybrook, NY
Liza Kelly: Sleep Technician, E.P. Bradley Hosp. Sleep Lab      Brown Univ Med School
Jeff Cerone: Sleep Technician, E.P. Bradley Hosp. Sleep Lab      Brown Univ Med School
Katherine Harrison:   Research Assistant     Rhode Island Hospital

8. Primary Research Focus Of Laboratory:

Field sleep research on children and adolescents’ sleep and behavior. The research group has a particular focus on the impact of sleep schedules, sleep deprivation, etc. on daytime behavior (e.g., mood, coping skills, school performance, etc.). The lab is also collecting preliminary data on working women’s sleep and behavior. Dr. Wolfson also collaborates with Dr. Mary Carskadon at the E.P. Bradley Hospital Sleep Lab, Brown University Medical School. As a result, students from Dr. Wolfson’s lab have the opportunity to get experience in Dr. Carskadon’s lab as well (e.g., polysomnography, actigraphy, etc.). In addition, students are able to intern at a clinical sleep lab affiliated with Memorial Hospital in Worcester.

9. Technical Capabilities Of The Lab: To date, Dr. Wolfson's lab is not equipped with polysomnography.

10. Primary Training Focus:

Research design, psychological and psychosocial measurement, sleep diary, actigraphy and sleep habits questionnaire
approaches, behavioral observations, computer skills (e.g., data entry, management, statistical analyses, etc.), and data
presentation.

11. Other Training Opportunities:

Once a year, Professor Wolfson offers a course titled, Sleep and Behavior. And, as stated above, students have the opportunity to work at the E.P. Bradley Hospital Sleep Lab with Dr. Carskadon and colleagues, and at local sleep labs in Worcester. Students also attend meetings of the Providence Sleep Research Interest Group and the Worcester Sleep Consortium..

12. Representative Publications For Last Five Years:

Wolfson, A., Lacks, P., & Futterman, A. (1992). The effects of parent training on infant sleeping patterns, parents' stress and perceived competence. Journal of Consulting and Clinical Psychology, 60 (1), 41-48.

Wolfson, A., & Carskadon, M. (1996). Early school start times affect sleep and daytime functioning in adolescents. Sleep Research, 25,117.

Wolfson, A. (1996). Sleeping patterns of children and adolescents: Developmental trends, disruptions and adaptations. In R. Dahl (Ed.), Child and Adolescent Psychiatric Clinics of North American, 5,(3), 549-668. Philadelphia: WB Saunders.

Wolfson, A. (in press). Working with parents on developing efficacious sleep/wake habits for infants and young children. In C. Schaefer and J. Briesmeister (Eds.), Handbook of Parent Training: Parents as Co-Therapists for Children’s Behavior Problems (2nd Edition). New York: John Wiley & Sons.

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1. Affiliation: 1996-1997 Entry - Montefiore Medical Center, and the Albert Einstein College of Medicine

2. Name & Address: Michael Thorpy M.D.

Montefiore Hospital
Sleep-Wake Disorders Center
111 East 210 Street
Bronx, NY 10467

Phone: (718) 920-4841
FAX: (718) 798-4352
E-Mail: aecom.yu.edu

3. Other Faculty: Saul Rothernberg Ph.D., Bernard Burack MD, Karen BalabanGil MD, Meeta Goswami Ph.D.

4. Type Of Training Available:

* Clinical Sleep Medicine full-time or parttime.
* Research training as studies become available.

5. Types Of Funding Available: Dependent upon research undertaken. Clinical training funds are sometimes available.

6. Number and Names Of Current Trainees: No full-time trainees at present

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Flavio Aloe Director Sleep Center in Sao Paulo
Gabriel Barthlen Director Sleep Center Mt Sinai Hosp, New York.

8. Primary Research Focus Of Laboratory: Clinical Sleep Medicine and Clinical Research

9. Technical Capabilities Of The Lab: Three polysomnographic recording rooms

10. Primary Training Focus: Clinical Sleep Medicine

11. Other Training Opportunities: Narcolepsy social services

12. Representative Publications For Last Five Years:

ASDA Practice Parameter Publications

Research publications in insomnia, narcolepsy and polysomnography.

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1. Affliliation: 1997-1998 Entry - Laboratory for Study of the Brain in Sleep, Department of Animal Biology, School of Veterinary Medicine

2. Name & Address: Adrian R. Morrison, D.V.M., Ph.D.

Department of Animal Biology, School of Veterinary Medicine,
University of Pennsylvania, Philadelphia, PA 191046045

Phone: (215) 898-8891
FAX: (215) 573-2004
E-Mail: armsleep@vet.upenn.edu

3. Other Faculty: Richard J. Ross, M.D., Ph.D. (Psychiatry): Larry D. Sanford, Ph.D. (Animal Biology).

4. Type Of Training Available:

Undergraduate: Research assistantships.
Training grants: Participation in three NIHfunded training grants
Graudate and undergraduate: Sleep course lectures.
Clinicianscientist training: As well as standard postdoctoral opportunities.

5. Types Of Funding Available (Trainee Support): 4 NIH Training Grants.

6. Types Of Funding Available (Laboratory Grants: 2 NIH Training Grants and 1 VA Grant.

7. Number and Names Of Current Trainees: (3)

Pre-doctoral:   Wendy K. Hunt, V.M.D.
Pre-doctoral:   Amy Silvestri
Postdoctoral   Tom DeBoer, Ph.D.

8. Students Who Have Completed Training In The Past Five Years and Current Status:

Ceile Hedberg, D.V.M., Ph.D. Chief veterinarian, RW Johnson Pharmaceutical Res. Institute, Raritan, NJ

Lewis Kline, M.D., Ph.D. Director, Sleep Disorders Center, West Penn Hospital, Pittsburgh, PA,

Larry D. Sanford, Ph.D. Research Asst. Professor, Laboratory for the Study of the Brain in Sleep, University of PA., School of Veterinary Medicine, Philadelphia, PA.

Richard L. Horner Assistant Professor, University of Toronto

9. Primary Research Focus Of Laboratory:

Motor control in REM.
Mechanisms of alerting and orienting.
Fear-potentiated startle.
Sleep in PTSD patients.

10. Technical Capabilities Of The Lab:

+ Four rooms for animal studies, including standard sleep recording, neuropharmacology, single-unit recording, behavioral manipulations.
+ Expertise in clinical neurology in animals.

11. Primary Training Focus: Basic sleep mechanisms.

12. Other Training Opportunities: We are part of the University's Institute of Neurological Sciences, which provides one of the premier training environments in the world.

13. Representative Publications For Last Five Years:

Sanford, L.D., W.A. Ball, A.R. Morrison, R.J. Ross and G.L. Mann, 1992. Peripheral and central components of alerting:
Habituation of acoustic startle, orienting responses, and elicited waveforms. Behav. Neurosci., 106:112-120.

Sanford, L.D., A.R. Morrison, W.A. Ball, R.J. Ross, and G.L. Mann, 1992. Spontaneous phasic activity in the brain:
differences between waves in lateral geniculate and central lateral nuclei across sleep states. J Sleep Res, 1:258-264.

Morrison, A.R., 1993. Mechanisms underlying oneiric behavior released in REM sleep by pontine lesions in cats. J Sleep Res, 2:4-7.

Sanford, L.D., R.J. Ross, A.E. Seggos, A.R. Morrison, W.A. Ball, and G.L. Mann, 1994. Central administration of two 5HT receptor agonists: effect on REM sleep initiation and PGO waves. Pharm. Biochem. & Behav., 49:93-100.

Sanford, L.D., A.R. Morrison, G.L. Mann, J.S. Harris, L. Yoo, and R.J. Ross, 1994. Sleep patterning and behavior in cats with pontine lesions creating REM without atonia. J. Sleep Res., 3:233-240.

Morrison,A.R., L.D.Sanford, W.A.Ball, G.L.Mann, R.J.Ross, 1995. Stimulus-elicited behavior in rapid eye movement sleep without atonia. Behav. Neurosci., 109:972-979.

Sanford,L.D., S.M.Tejani-Butt, R.J. Ross, and A.R.Morrison, 1995. Amygdaloid control of alerting and behavioral arousal in rats: involvement of serotonergic mechanisms. Arch. ital. Biol., 134:81-99.

Sanford,L.D., S.M. Tejani-Butt, R.J. Ross, and A.R. Morrison, 1996. Elicited PGO waves in rats: lack of 5-HT (1A) [these are to be subscripted but cannot do on this e-mail system] inhibition in putative pontine generator region. Pharm. Biochem. & Behav., 53:323-327.

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1. Affiliation: 1997-1998 Entry - Unit for Experimental Psychiatry, Division of Sleep and Gerontology, Department of Psychiatry, University of Pennsylvania School of Medicine

2. Name & Address: David F. Dinges, Ph.D.

   Director, Unit for Experimental Psychiatry
   Chief, Division of Sleep and Chronobiology
   University of Pennsylvania School of Medicine
   1013 Blockley Hall, 423 Guardian Drive
   Philadelphia, PA 19104

   Phone: (215) 898-9949
   FAX: (215) 573-6410
   E-Mail: dinges@mail.med.upenn.edu

3. Other Faculty:

Janet Mullington, PhD (Psychiatry), Marty Szuba, MD (Psychiatry), Edward Schweizer, MD (Psychiatry), Wayne G. Whitehouse, PhD (Psychiatry); Collaborative faculty: Allan I. Pack, MD, PhD (Medicine/Psychiatry), Steven D. Douglas, MD (Microbiology), Shiv Kapoor, PhD (Medicine), Terri Weaver, PhD (Nursing)

4. Types of Training Available:

Training from the undergraduate through early career:
* Undergraduate and graduate courses in sleep and circadian rhythms (e.g., BBB340 in Biological Basis of Behavior program in College of Arts and Sciences and School of Medicine).
* Undergraduate work-study and research assistantships.
* Pre-doctoral and post-doctoral research fellowships on sleep and circadian regulation of alertness.
* Preceptoring for early career awards to MDs and PhDs doing sleep/circadian research.
* Research assistantships.

5. Types Of Funding Available:

   * Work-study stipends for undergraduates (10).
   * Research assistantships (part-time and fulltime) for undergraduates, pre-med students, and pre-graduate school students (10).
   * Graduate student support (2).
   * Pre-doctoral fellowships (2).
   * Post-doctoral fellowships (2).
6. Types of Funding (current laboratory grants only--does not include grants pending):

* AFOSR PRET Center experiments on homeostatic and circadian regulation of wakefulness during jet lag and sleep deprivation: Effects of wake-promoting countermeasures (funding through 2000);
* NIH R01 on the neurobehavioral and neuroendocrine effects of cumulative partial sleep deprivation (funding through 1998);
* NIH SCOR studies of daytime sleepiness and function on CPAP therapy for apnea (funding through 1998);
* NASA (with Mark Rosekind, PhD) studies on crew alertness management on the flight deck (funding through 1997);
* DOT / NHTSA studies on evaluation of technologies for sleepiness detection and alertness management (funding through 1997);
* AAAF study of drowsy driving and behavioral countermeasures (funding through 1997);
* NIH R01 (with Allan Pack, MD, PhD) studies of sleepiness in the elderly (funding through1997);
* NIH R01 (with Allan Pack, MD, PhD) case-control study of insomnia in non-depressed elderly (funding through 2002).

7. Number and Names of Current Trainees: (7)

Preceptorship (2): Marty Szuba, MD; Deepak Chugh, MD, MBChB
Post-doctoral Fellows (1): Janet Mullington, PhD
Resident (1):    Tony Fernando, MD
Pre-doctoral Fellows (1):   Megan Jewett
Graduate students (2):    Melissa Mallis; Ravi Mariathason

Undergraduate trainees (22):   Matthew Arkin; David Blake; Jennifer Chachkes; Rebecca Chusid; Edward Dale; Natalie
               Denney; Rascha Dughly; Leslie Goldfein; Leexan Hong; Cathy Hwang; Beatrice Jauregui;
               Amit Kapoor; Nicole Konowal; Erica Levine; Lucy MacGillis; Jennifer McKenna; Raj Mittal;
               Bradley Moore; Lan Nguyen; Elana Piller; Avi Raval; Charles Rosenbaum.

8. Students Who Have Completed Training In Past Five Years and Status:

   Terri Weaver, PhD, RN   Asso. Professor    University of Pennsylvania School of Nursing
   Richard Ross, MD, PhD      Asso. Professor     VA Medical Center and University of Pennsylvania
   Patricia Sollars, PhD      Asst. Professor     Colorado State University
   Geoffrey Ott       Graduate student     UCLA Neuroscience (Sleep Res. Training Program)
   Marieke Dijkman     Medical Student     University of Groningen, The Netherlands
   David Winokur     Medical student       St. George's University School of Medcine
   Kim Steinberg, MD     Physician       University of Rochester School of Medicine
   Allison Cromwell, MD     Physician       University of Chicago School of Medicine
   Edward Icaza, MD    Neurologist     St. Joseph's Hospital and Medical Center, Phoenix

9. Primary Research Focuses Of Laboratory:

Basic human neurobehavioral and neurobiological research, involving both laboratory and field experiments. Investigation of the homeostatic and circadian regulation of waking neurobiological functions, and the manner in which they interact to produce wakefulness. Specific areas of study include: (1) the effects of sleep deprivation on behavioral and physiological functioning; (2) the cumulative development of sleepiness and brain dysfunction from acute total and sustained partial sleep loss; (3) neurobehavioral deficits due to sleepiness and hypoxemia from obstructive sleep apnea syndrome; (4) neuroimaging during sleep and sleep loss; (5) neuroendocrine and neuroimmune functions in relation to sleep, sleep loss, and circadian rhythms; (6) sleep disturbance in psychopathology; (7) causes of insomnia and excesssive sleepiness in the elderly; (8) effects of irregular, prolonged, and shifted work schedules human health and safety; (9) development of behavioral, biological, and technological countermeasures to inadequate sleep and to daytime sleepiness; (10) effects of caffeine, posture and stimulation of brain functions during sleep deprivation; (11) development of mathematical models of human neurobehavioral functions; (12) transition of basic research on human sleep/wakefulness to public policy issues..

10. Technical capabilities of lab:

   + facilities for multi-day (24-hr) experiments on human sleep deprivation
   + temporal isolation facilities for prolonged circadian rhythm experiments
   + state-of-the-art digital, ambulatory, portable EEG / EOG / EMG recorders
   + portable, digital polysomnography equipment
   + EEG signal processing hardware/software
   + time-locked integration of facial video, EEG, and performance
   + core body temperature assessment
   + actigraphy and actillume hardware/software
   + computer-based, portable performance/neurobehavioral assessment systems
   + blood/saliva/urine processing facilities for neuroendocrine and neuroimmune measures

11. Primary Training Focus:

Fellowship and stipend support at all levels (undergraduate, medical student, graduate, post-doctorate, early career), as described above. Laboratory is heavily invested in studying neurobehavioral (e.g., performance, cognitive, EEG, fMRI, metabolism, mood, somatic symptoms), neuroendocrine (e.g., cortisol, melatonin, thyroid axis, growth hormone, catecholamines), and in vitro and in vivo neuroimmune functions (e.g., cytokines, lymphocyte responses) in healthy humans as a function of sleep drive and circadian rhythmicity. Emphasis is placed on trainees taking responsibility for developing key aspects of research and bringing to publishable fruition as their product. Career development with achievable goals are priorities.

12. Other Training Opportunities:

NIH (NHLBI) support for 2-year post-doctoral NIH fellowships in respiratory neurobiology and sleep (Allan I. Pack, MD, PhD). Graduate students in the Neuroscience Department and Psychology Department are eligible to work with Dr. Dinges, who is a member of the Institute of Neurological Sciences, the Psychology Graduate Group, and the Training Faculty of the Center for Sleep and Respiratory Neurobiology at Penn.

13. Representative Publications For Last Five Years:

Dinges, D.F. (1995) An overview of sleepiness an accidents. Journal of Sleep Research 4:Suppl. 2, 4-14.

Gary, K.A., Winokur, A., Douglas, S.D., Kapoor, S., Zaugg, L., Dinges, D.F. (1996) Total sleep deprivation and the thyroid axis: effects of sleep and waking activity. Aviation, Space, and Environmental Medicine, 67(6):513-519.

Chugh, D.K., Weaver, T.E., Dinges, D.F. (1996) Neurobehavioral consequences of arousals. Sleep 19(10):S198-201.

Dinges, D.F., Pack, F., Williams, K., Gillen, K.A., Powell, J.W., Ott, G.E., Aptowicz, C., Pack, A.I. 1997) Cumulative sleepiness, mood disturbance, and
psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep, 20(4).

Dinges, D.F., Chugh, D. (In press) Physiological correlates of sleep deprivation. In Kinney, J.M. (Ed.) Physiology, Stress and Malnutrition, Lippincott-Raven, New York.

- 18 -

1. Affiliation: 1996-1997 Entry - Center for Sleep and Respiratory Neurobiology University of Pennsylvania

2. Name & Address: Allan I. Pack, M.D., Ph.D.

University of Pennsylvania
Medical Center, Philadelphia, PA 191044283

Phone: (215)-662-3302
FAX: (215)-662-7749
E-Mail: packa@a1.mscf.upenn.edu

3. Other Faculty: Richard O. Davies, D.V.M., Ph.D.; David F. Dinges, Ph.D.; Leszek Kubin, Ph.D.; Scott Manaker, M.D., Ph.D.; R. Morrison, D.V.M., Ph.D.; Gary E. Pickard, Ph.D.; Richard J. Schwab, M.D.; Amita Sehgal, Ph.D.; Brian L. Strom, M.D., M.P.H.; Andrew Winokur, M.D., Ph.D.

4. Types of Training Available: Postdoctoral training (2 years) in mechanisms of sleep and sleep apnea.

5. Types Of Funding Available: Postdoctoral trainee stipends, single health coverage, travel (1 meeting/year) and supplies

6. Number and Names Of Current Trainees:

Postdoctoral trainees (8): Mark Baumel, M.D., Michael Brennick,Ph.D., Deepak Chugh, M.D., Melissa Cohen, M.D., Richard Fay, Ph.D., Wendy Hunt, V.M.D., Miroslaw Mackiewicz, Ph.D., Ulysses Magalang, M.D.
Graduate students: None

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Richard Schwab, M.D. Assistant Professor University of Pennsylvania
Basil Petrof, M.D. Assistant Professor Royal Victoria Hospital,Quebec, Canada
Tracy BarrettTangoren, M.D. Postdoctoral Fellow University of Pennsylvania
Patricia Sollars, Ph.D. Research Assistant Professor University of Pennsylvania
Aili Lazaar, M.D. Postdoctoral Research University of Pennsylvania

8. Primary Research Focus of Laboratory:

+ Basic mechanisms of sleep
+ Pathogenisis of sleep apnea
+ Basis of circadian rhythm
+ Sleep deprivation and effects on performance
+ Drowsy driving

9. Technical Capabilities Of The Lab:

* Chronic animal recordingmicroinjection/single cell recording
* Reduced preparations/extracellular and intracellular recording
* Genetic studies in Drosophila
* Molecular biology laboratory
* Brainslide studies
* Neuroanatomy
* Microdialysis
* Clinical Research Center for Sleep and Chronobiology (4 bedrooms with all relevant recording instrumentation)
* Computerized sleep scoring equipment

10. Primary Training Focus

To provide training individual in mechanisms of sleep and respiratory neurobiology

11. Other Training Opportunities: No information provided.

12. Representative Publications For Last Five Years:

Kubin L, Kimura H, Tojima H, Davies RO, Pack AI. Suppression of genioglossal motoneurons during carbacholinduced atonia of REM sleep is not caused by fast synaptic inhibition. Brain Research 611:300312, 1993.

Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, Redline S, Henry JN, Getsy JE, Dinges DF. Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis 147:887895, 1993.

Rosekind MR, Graeber RC, Dinges DF, Connell LJ, Rountree M, Gillen KA. Crew factors in flight operations: IX. Effects of cockpit rest on crew performance and alertness in longhaul operations. NASA Techical Memorandum Report No. 103884, pp 252, 1993.

Hendricks JC, Petrof BJ, Panckeri K, Pack AI. Upper airway dilating muscle hyperactivity during nonrapid eye movement sleep in English bulldogs. Am Rev Respir Dis 148:185194, 1993.

Manaker S, Tischler L. Origin of serotonergic afferents to the hypoglossal nucleus in the rat. J Comp Neurol 334:466476, 1993.

Sanford L, Morrison A, Ball W, Ross R, Mann GL. The amplitude of PGO waves: a correlate of orienting. Electroenceph Clin Neurophysiol 86:438445, 1993.

Schwab RJ, Gefter WB, Hoffman EA, Gupta KB, Pack AI. Dynamic upper airway imaging during respiration in normal subjects and patients with sleep disordered breathing. Am Rev Respir Dis 148:13851400, 1993.

Sollars PJ, Pickard GE. Timecourse of fiber outgrowth from fetal anterior hypothalamic heterografts. Brain Research 614:212219, 1993.

Kubin L, Reignier C, Tojima H, Taguchi O, Pack AI, Davies RO. Changes in serotonin level in the hypoglossal nucleus region during the carbacholinduced atonia. Brain Research 646:291302, 1994.

- 19 -

1. Affiliation: 1997-1998 Entry - University of Pittsburgh Medical Center Department of Psychiatry

2. Name: Ronald E. Dahl, M.D.

Western Psychiatric Institute and Clinic
3811 O'Hara Street, Room E-733
Pittsburgh, PA 15213

Phone: (412) 624-7740
FAX: (412) 624-0223
E-Mail: dahlre@msx.upmc.eduu

3. Other Faculty: Neal Ryan, M.D., David Brent, M.D., Joan Kaufman, Ph.D., B.J. Casey, Ph.D.

4. Types of Training Available:

*Two-year fellowship in psychobiology of child and adolescent psychiatric disorders (with an opportunity to focus on sleep) and biological-rhythms research.
* NIMH-funded trainees may also pursue certification in sleep disorders medicine ASDA-approved fellowship.

5. Types Of Funding Available:

NIMH Funded Post Doctoral Fellowships - stipends range from $19,608 - 32,300.
NIMH Training Grant Seed Money - Awards of up to 10,000 for one year

6. Number and The Names Of Current Trainees: (2)

Christopher Kye, M.D., Abby Schlesinger

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Joan Kaufman, Ph.D. Assistant Professor of Psychiatry University of Pittsburgh Medical Center
Michael Debellis, M.D. Assistant Professor of Psychiatry University of Pittsburgh Medical Center
David Rosenberg, M.D. Assistant Professor of Psychiatry University of Pittsburgh Medical Center
Uma Rao, M.D. Assistant professor of Psychiatry UCLA

8. Primary Research Focus Of Laboratory:

Sleep, stress and neuroendocrine regulation in relation to child and adolescent psychiatric disorders

9. Technical Capabilities Of The Lab:

+ Can study up to 5 children/adolescents at a time
+ Excellent facility for psychobiologic studies in children
+ Integration of sleep with imaging studes (fMRI) and other psychobiologic and psycho-physiologic studies

10. Primary Training Focus:

Post-doctoral clinical research training in psychobiologic, psychiatric studies of child and adolescent disorders.

11. Other Training Opportunities:

Through other Mental Health Clinical Research Centers in mood disorders (core expertise and seed money funding in psychopharmacology, functional imaging, and psychosocial studies)

12. Representative Publications For Last Five Years:

Dahl RE: The regulation of sleep and arousal: Development and Psychopathology. Development and Psychopathology, 8
3-27, 1996.

Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Rao R, Kaufman J, Nelson B: Predicting onset and course of unipolar depression in adolescents using sleep and cortisol measures. Biological Psychiatry, 40:474-484, 1996.

Birmaher B, Dahl RE, Perel J, Williamson DE, Nelson B, Stull S, Kaufman J, Waterman GS, Rao U, Nguyen N, Puig-Antich J, Ryan ND: Corticotropin releasing hormone challenge test in prepubertal major depression. Biological Psychiatry, 39:
400-410, 1996.

Dahl RE, Holttum J, Trubnick L: The clinical presentation of narcolepsy in children and adolescents. Journal American Academy
of Child and Adolescent Psychiatry 33:6:834-841;1994. Reprinted in: Annual Progress in Child Psychiatry and Child
Development. Edited by Margaret E. Hertzig, M.D., Ellen A. Farber, Ph.D., Brunner/Mazel Publisher. New York, 351-365;1995.

Dahl RE, Scher MS, Williamson DE, Robles N, Day N: A longitudinal study of prenatal marijuana use: effects on sleep and
arousal at age 3 years. Archives of Pediatrics and Adolescent Medicine 149:145-150;1995.

Dahl RE, Bernhisal-Broadbent J, Scanlon-Holdford S, Lupo M, Sampson HA, Al-Shabbout M: Sleep distrubances in children with
atopic dermatitis. Archives of Pediatrics and Adolescent Medicine 149:856-860;1995.

Williamson DE, Dahl RE, Birmaher B, Goetz RR, Ryan ND: The relationship between stressful life events and EEG sleep in
depressed and normal control adolescents. Biological Psychiatry 34:591-598;1995.

Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Giles DE, Rao R, Kaufman J, Nelson B: The relationship between
longitudinal clinical course and sleep and cortisol changes in adolescent depression. Biological Psychiatry 34:566-578;1995.

Dahl RE, Matty MK, Birmaher B, Al-Shabbout M, Williamson DE, Ryan ND: Sleep onset abnormalities in depressed adolescents.
Biological Psychiatry (in press)

Schlesinger A, Dahl RE, Redfern M, Jennings R: Sleep deprivation impairs the control of postural balance while performing
a cognitive task. Sleep Research, 25, 477, 1996.

- 20 -

1. Affiliation: 1997-1998 Entry - University of Pittsburgh Medical Center, Department of Psychiatry

2. Name & Address: Charles F. Reynolds III, M.D.

Western Psychiatric Institute and Clinic
Department of Psychiatry, University of Pittsburgh
3811 O'Hara Street, Pittsburgh, PA 15213

Phone: (412)-624-2246
FAX: (412)-624-2841
E-Mail: reynolds@msx.upmc.edu

3. Other Faculty:

David J. Kupfer, M.D.; Timothy H. Monk, Ph.D.; Daniel J. Buysse, M.D.; Ronald Dahl, M.D.; Eric Nofzinger, M.D.

4. Types Of Training Available:

+ Two-year fellowship in psychiatric sleep and biological-rhythms research
+ NIMH-funded trainees may also pursue certification in sleep disorders medicine through our ASDA-approved fellowship.
+ Graduate research associateships

5. Types Of Funding Available:

* NIMH Funded Post Doctoral Fellowships - stipends range from $ 20,292 - 32,300.
* NIMH Training Grant Seed Money - Awards of up to 10,000 for one year

6. Number and Names Of Current Trainees: (3) Post doctoral fellows.

Post Doctoral Fellows: Martica Hall, Ph.D., Julie Carrier, Ph.D., Peter Nowell, MD

Graduate Student : None Currently

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Jung H. Lee, M.D.    Assistant Professor of Psychiatry   Case Western Reserve University
Daniel Brunner, Ph.D.    Sleep Specialist     Clinic for Sleep Medicine Zurzach, Switzerland
Michael L. Perlis, Ph.D.   Assistant Professor of Psychiatry University of Rochester, Dept. of Psychiatry

8. Primary Research Focus Of Laboratory :

+ Sleep and biological rhythms in major psychiatric syndromes
+ Sleep and biological rhythms in healthy aging across the life cycle
+ Shift work and related issues.

9. Technical Capabilities Of The Lab:

* can study up to 10 patients nightly
* time-isolation facility
* period/amplitude and spectral analysis
* extensive experience with field studies
* integration with imaging studies (PET, fMRI)

10. Primary Training Focus :

Post-doctoral clinical research training in psychiatric sleep and biological rhythms research.

11. Other Training Opportunities:

Through Mental Health Clinical Research Centers in midlife and late-life mood disorders (core expertise and seed money funding in psychopharmacology, functional imaging, and psychosocial studies including intervention, statistics)

12. Representative Publications For Last Five Years :

Buysse DJ, Browman KE, et al. Napping and 24-hour sleep-wake patterns in healthy elderly and young adults. Journal of the American Geriatrics Society 40: 779-786, 1992.

Nofzinger EA, Thase ME, et al. Sexual function in depressed men: assessment using self-report, behavioral, and nocturnal penile tumescence measures before and after treatment with cognitive behavioral therapy. Archives of General Psychiatry 50: 224-30, 1993.

Lee JH, Reynolds CF, et al. EEG sleep in recently remitted, elderly depressed patients in double-blind maintenance placebo therapy. Neuropsychopharmacology 8: 143-150, 1993.

Neylan TC, Reynolds CF, et al. Sleep Disorders. In: Hales, Yudofsky, and Talbot (eds), Textbook of Psychiatry, second edition, American Psychiatric Press, Inc., Washington, D.C., 1994, pp 833-855.

Buysse DJ, Perlis ML The evaluation and treatment of insomnia. Journal of Practical Psychiatry and Behavioral Health,
in press.

Perlis ML, Giles DE, Fleming G, Drummond P, James S Sustained facial muscle activity during REM sleep in depressed subjects and its correlation with self reported depression. Journal of Affective Disorders, 35:163-171, 1995.

Perlis ML, Buysse, D, Giles, DE, Tu X., Kupfer DJ. Sleep disturbance may be a prodromal symptom of depression. Sleep Research, 25, 171.

Perlis ML, Buysse DJ, Thase ME, Tu XL, Giles DE, Kupfer DJ Which depressive symptoms relate to which sleep EEG variables. Submitted Biological Psychiatry.

Reynolds C.F.III and Brunner D.P. Sleep microarchitecture in Depression: Commentary. Biological Psychiatry, 1995, 37: 70.

Reynolds C.F.III, Buysse D.J., Brunner D.P., et al. Maintenance nortriptyline effects on homeostatic regulation of sleep in elders with recurrent major depression: double-blind, placebo- and plasma-level-controlled evaluation. Journal of Biological Rhythms, 1996, submitted.

Brunner D.P., Vasco R.C., Detka C.S., Monahan J.P., Reynolds C.R., Kupfer D.J. Muscle artifacts in the sleep EEG: automated detection and effect on all-night EEG power spectra. Journal of Sleep Research, 1996, submitted.

Nowell P, Buysse, D, Reynolds, C & Kupfer, D. Which Clinical Factors Contribute To Primary Insomnia vs. Insomnia Related To A Mental Disorder? Sleep Research, 26, 318.

Nowell P, Buysse, D, Reynolds, C & Kupfer, D. A Review Of Clinical Trial Design And Hypnotic Efficacy For Primary Insomnia, Sleep Research, 26, 319.

Nowell, P.D., Buysse, D.J. Reynolds, C.F. et al., (Submitted). Clinical Factors Contributing to the Differential Diagnosis of Primary Insomnia and Insomnia Related to Another Mental Disorder. American Journal of Psychiatry

Nowell PD, Buysse DJ, Morin CM, Reynolds CF, Kupfer DJ (In press) Effective Treatment for Selected DSM-IV Sleep Disorders. Psychotherapies and Drugs that Work: A Review of the Outcome Studies.

Carrier, J., Monk, T.H., Buysse, D.J., Kupfer, D.J. Inducing a 6-hour phase advance in the elderly: effect on sleep and temperature rhythms. (Journal of Sleep Research: in revision, April 1996)

Carrier, J., Monk, T.H., Buysse, D.J., Kupfer, D.J. Amplitude Reduction of the circadain temeprature and sleep rhythms in the elderly. submitted Chronobiology International)

Carrier, J., Monk, T.H., Buysse, D.J., Kupfer, D.J. Inducing a 6-hour phase advance in the elderly: sleep and rhythm amplitude effects. Abstract accepted for an oral presentation to the 5th Meeting of the Society for Research on Biological Rhythms.

Carrier, J., Monk, T.H., Buysse, D.J., Kupfer, D.J. The effects of a 6-hour phase advance of the sleep-wake cycle on sleep in older subjects. Sleep Research, 26, 543.

Hall, M., Dougall, A., Buysse, D.J., Dew, M.A., Reynolds, C.F., & Baum, A. (submitted). Sleep quality following a traumatic event predicts future health and psychosocial distress. Health Psychology.

Hall, M.H., Buysse, D.J., Reynolds, C.F., & Baum, A. (1996). Sleep as a predictor of long-term functioning in the wake of a traumatic event. Sleep Research, 26, 161.

Hall, M.H., Buysse, D.J., Reynolds, C.F., & Baum, A. (1996). Sleep quality predicts symptoms of depression and psychosocial distress in healthy young adults. Sleep Research, 26, 162.

Hall, M.H., Buysse, D.F., Reynolds, C.F., Kupfer, D.J., & Baum, A. (1996). Stress-related intrusive thoughts interfere with sleep onset and continuity. Sleep Research, 26, 163.

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1. Affiliation: 1997-1998 Entry - University of Rochester Medical Center & St. Mary's Sleep Disorders Center

This program started in 1996 and provides trainees the opportunity to work in both clinical and research settings. Clinical opportunities are available through the St. Mary's Sleep Disorders Center under joint supervision with Donald W. Greenblatt, MD (Sleep Center Director), Donna Giles, PhD and Michael Perlis, PhD. Research opportunities are available at both the sleep disorders center and through the URMC Sleep Research laboratory which is housed in the Department of Psychiatry.

2. Name(s) & Address:

Donna E. Giles, PhD., Michael L. Perlis, Ph.D.
University of Rochester - Departments of Psychiatry & Neurology
300 Crittenden Blvd.
Rochester, NY 14642

Donald W. Greenblatt, MD
2100 Clinton Avenue
Rochester, NY

Phone: (716) 275-563; FAX: (716) 275-7366;
E-Mail: mperlis@obgyn.rochester.edu dgreenb431@aol.com

3. Other Faculty:

Faculty from the departments of Psychiatry, Pulmonology and Neurology are involved with both the clinical and research
components of our program. Our primary collaborator, however, is Michael R. Privitera, M.D. (Mood Disorders Center).

4. Type Of Training Available:

     - supervision for sleep related theses/dissertations from intra or extramural degree granting departments
     - clinical and research Ph.D. internship rotations
     - pulmonary resident and/or fellowship training
     - research and/or clinical post doctoral fellowships

5. Types Of Funding Available (Trainee Support):

      - University of Rochester funded positions for two research assistants/technicians
      - Grant Funded clinical assessor position (1 year)
      - University of Rochester funded position for one research fellow (1-2 year appointment)
      - St. Mary’s Hospital funded resident and/or fellowship Positions

6. Types Of Funding (Laboratory Grants):

MH39531 Is EEG sleep abnormal in those at risk for depression.    PI: DE Giles
MH56869-01 The role of REM sleep arousal in major depression   PI: ML Perlis
NARSAD Sleep disturbance as a possible prodromal symptom of depression   PI: ML. Perlis

7. Number and Names Of Current Trainees:

Psychiatry & URMC Sleep Research Laboratory: 4 Research Assistants/Project Coordinators: Kimberly Searl, Henry Orff, Patrick Andrews, Colleen McCallum

Pulmonary & Critical Care & Sleep Disorders Center: 8 fellows rotate per year

8. Students Who Have Completed Training in the Past 5 Years and Current Positions:

Giles:

Melanie M. Biggs, Ph.D. Instructor Dept of Psychiatry University of Texas Southwestern Medical Center
Nancy H. Hoffman, Ph.D. Senior Clinician Dept of Psychiatry University of Pittsburgh Medical Center
Janyce G. Dyer, DNSc Asst Professor School of Nursing University of Pittsburgh

Greenblatt:

Kim Searl, B.A. RA/Project Coordinator URMC Sleep Research Laboratory
Timothy Evans, MD Sr. Instructor University of Rochester
Joseph Modrak, MD Sr. Instructor University of Rochester
John Fogarty, MD Private Practice North Carolina
Alfonso Torres, MD Fellow University of Rochester

Perlis:

Ken Wright, PhD Research Fellow   Harvard University, MA
Sean Drummond, B.S.   Graduate Student   UCSD/SDSU Joint Doctoral program, CA
Mary Rose, M.A.   Graduate Student   Virginia Consortium for Professional Psychology

9. Primary Research Focus Of Laboratory:

EEG sleep as a means of identifying clinical course in major depression
EEG sleep measures as a means of identifying familial transmission in major depression
Self reported sleep disturbance as a prodromal symptom of depression
EMG activity as an index of arousal during REM sleep and a marker of mood dysregulation
Memory function peri-sleep onset as a mediator of perceived poor sleep quality
Behavioral vs. pharmacologic treatment in insomnia
Mediating factors in pharmacologic treatment of insomnia

10. Technical Capability Of The Lab:

The clinical facility is operated by St. Mary’s Hospital and is a 8 bed free-standing facility with standard
polysomnographic capability and digital acquisition and analyses capability through Healthdyne systems. The research laboratory is currently configured as a one bed-3 room suite. This environment can be immediately expanded to a two bed-5 room suite as the need arises. PSG capability includes 16 wide band AC amplifiers, 2 DC amplifiers, 10 in-line Coulbourn 48db/oct pass band filters, and digital acquisition & PSA analyses capability via Stellate’s Eclipse, Rhythm and Harmonie systems. The lab also has video and intercom capability and 1 dedicated high end PC computer system for stimuli administration and performance measures.

11. Primary Training Focus:

Graduate clinical or research training, internship rotations, residents training opportunities and postdoctoral fellowships.

12. Other Training Opportunities: To be determined - based on developing clinical/research program

13. Representative Publications For Last Five Years:

Giles DE, Roffwarg HP, Dahl RE, Kupfer DJ. EEG sleep abnormalities in depressed children: a hypothesis. Psychiatry Res 1992 Jan; 41:53-63.

Giles DE, Jarrett RB, Rush AJ, Biggs MM, Roffwarg HP. Prospective assessment of EEG sleep in remitted major depression. Psychiatry Res 1993 Mar; 46:269-284.

Dyer JG, Giles DE. Familial influence in unipolar depression: Effects of parental cognitions and social adjustment on adult offspring. Compr Psychiatry, 1994 July/August; 35(4):290-295.

Giles, DE, Perlis ML, Reynolds CF, Kupfer DJ. EEG sleep in African Americans with unipolar depression: A historical case study control. Sleep Research, 25: ***. 1997.

Giles DE, Kupfer DJ, Perlis ML. A test of the primary sleep defect in depression using a family study model. Biological Psychiatry (Abstracts), ***: ***, 1997.

Perlis ML, Giles DE, Fleming G, Drummond P, James S. Sustained facial muscle activity during REM sleep in depressed subjects and its correlation with self reported depression. Journal of Affective Disorders, 35:163-171, 1995.

Perlis ML, Buysse DJ, Thase ME, Tu XL, Giles DE, Kupfer DJ. Which depressive symptoms relate to which sleep EEG variables. In press - Biological Psychiatry.

Perlis ML, Bootzin RR, Fleming G, Drummond SP, Rose M, Dikman ZV, Giles DE. Alpha sleep and information processing, perception of sleep, pain and arousability in fibromyalgia. International Journal of Neuroscience 1997; 89: 265-280.

Perlis ML, Buysse, D, Giles, DE, Tu X, Kupfer DJ. Sleep disturbance may be a prodromal symptom of depression. Journal of Affective Disorders 1997; 42: 209-212.

Perlis ML, Artiola L, Giles DE. The incidence sleep complaints in Post Concussion Syndrome. Perceptual Motor Skills1997; 84: 595-599.

Perlis ML, Searl KA, Giles, DE, Buysse, D. Partial sleep deprivation in healthy control subjects: differential effects on motor activity. Sleep Research, 25: ***: 1997.

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1. Affiliation: 1996-1997 Entry - Department of Psychology, St. Joseph's University Sleep Disorders Center, Medical College of Pennsylvania and Hahnemann Univ.

2. Name & Address: Jodi A. Mindell, Ph.D.

Department of Psychology
St. Joseph's University, Philadelphia, PA 19131

Phone: (215)-6601806
FAX: (215)-660-1819
E-Mail: jmindell@sju.edu

3. Other Faculty:

June M. Fry, M.D., Ph.D. & Rochelle Goldberg, M.D. (Medical College of Pennsylvania)

4. Types Of Training Available:

Undergraduate research students
Graduate students enrolled in our M.S. program in Experimental Psychology with a focus on health psychology.

5. Types Of Funding Available:

Competitive teaching assistantships are available to our graduate students in their second year of the program.

6. Number and Names Of Current Trainees:

Graduate students: Rivka Pollack, Jennifer Groff, Jennifer French, Debbie Miller, Ave French, Amy Williamson
Undergraduate students: Kirsten Lyman

7. Students Who Have Completed Training In The Past Five Years and Their Current Status:

Maria Aranda Doctoral Candidate Clinical Psychology, Catholic University
Amy Schuhl Doctoral Student Neuroscience, Hahnemann University
Laurie Cashman Research Associate Medical College of Pennsylvania
Karen Moran Research Associate Medical College of Pennsylvania

8. Primary Research Focus Of Laboratory:

Sleep and sleep disorders in children and adolescents (Dr. Jodi Mindell)
Narcolepsy (Dr. June Fry)
Pharmacological treatments for insomnia (Dr. June Fry)
Sleep apnea (Dr. Rochelle Goldberg)
Medical school training in sleep and sleep disorders (Dr. Rochelle Goldberg)

9. Technical Capabilities Of The Lab:

Five bedroom sleep clinical/research lab at Medical College of Pennsylvania

10. Primary Training Focus:

Undergraduate training and graduate training in experimental psychology

11. Other Training Opportunities:

Sleep Disorders Center at Lankenau Hospital (Dr. Mark Pressman)

12. Representative Publications For Last Five Years:

Mindell, J. A. (1993). Sleep disorders in children. Health Psychology, 12,152163.

Mindell, J. A., & Durand, V. M. (1993). Treatment of childhood sleep disorders: Generalization across disorders and effects on family members. Pediatric Psychology, 18, 731750.

Mindell, J. A., Moline, M. L., Zendell, S. M., Brown, L. B., & Fry, J. M. (1994). Pediatricians and sleep disorders: Training and practice. Pediatrics, 94, 194200.

Mindell, J. A., Goldberg, R., & Fry, J. M. (in press). Treatment of a circadian rhythm disorder in a blind 2yearold child. Journal of Visual Impairment and Blindness.

Mindell, J. A., & DeMarco, C. (in press). Sleep problems in young, visually impaired children. Journal of Visual Impairment and Blindness.

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