_ = This type of training does NOT exist in the program

? = It is not known whether this type of training exists in the program 

1. Affiliation: 1997-1998 Entry -  University of Alberta, CANADA - Department of Psychology

2. Name & Address: Don Kuiken, Ph.D.

University of Alberta - Dept. of Psychology Biological Sciences Building
Edmonton, Alberta T6G 2E9 CANADA

Phone: (403) 492-2559;
FAX: (403) 492-1768;
E-Mail: dkuiken@PSYCH.UALBERTA.CA

3. Other Faculty: Leo Mos, Ph.D. and Jayne Gackenbach, Ph.D., are occasional research collaborators.

4. Type Of Training Available:

* Undergraduate Honors Thesis research on dreaming
* Graduate Student Thesis research on dreaming

5. Types Of Funding Available:

Given satisfactory progress in their studies, all graduate students admitted into the program are provided funding through some combination of teaching assistantships and research assistantships.

6. Number and Names Of Current Trainees:

Agnes Kwong, Crystal Kasper, Michael Bears (Honors students)
Ria Busink, Shelley Sikora (Graduate Students)

7. Students Who Have Completed Training In The Past Five Years and Their Current Status:
 

8. Primary Research Focus Of Laboratory:

+ Dreams and feeling expression
+ Dreams and bereavement

9. Technical Capabilities Of The Lab:

* Two bedroom research lab
* Period/amplitude computer analysis

10. Primary Training Focus: Graduate education in psychology (Ph.D.)

11. Other Training Opportunities: No information provided.

12. Representative Publications For Last Five Years:

 Kuiken, D. (1995).  Dreams and connectionism:  A critique.  Journal of Intelligent Systems, 4, 263-278.

 Kuiken, D. (1995).  Dreams and feeling realization.  Dreaming, 5, 129-157.

 Busink, R., & Kuiken, D. (1995).  Identifying types of impactful dreams:  A replication.  Dreaming, 97-119.

 Kuiken, D., & Nielsen, T.A. (1996).  Individual differences in orienting activity mediate feeling realization in dreams:  I.
 Evidence from retrospective reports of movement inhibition.  Dreaming, 201-217.

 Kuiken, D., Busink, R., Dukewich, T.L., & Gendlin, E.T. (1996).  Individual differences in orienting activity mediate feeling
 realization in dreams:  II. Evidence from concurrent reports of movement inhibitition.  Dreaming, 251-264.

1. Affiliation: 1997-1998 Entry -  Chronobiology Laboratory, Psychiatric Hospital, University of Basel

2. Name & Address: Anna Wirz-Justice, Ph.D.

Chronobiology Laboratory - Psychiatric University Clinic
Wilhelm Klein Strasse 27
CH-4025 Basel, SWITZERLAND

Phone: (41)-61-325-5473 [Direct]; (41)-61-325-5474 [Lab];
FAX: (41)-61-325-5514 [Direct]; (41)-61-325-5258 [Hospital];
E-Mail: WIRZ@ubaclu.unibas.ch

3. Other Faculty: Kurt Kraeuchi, M.S.

4. Type Of Training Available: Studies of human chronobiology; constant routine methodology

No formal course in chronobiology; Studies of Human Chronobiology:  Constant Routine Laboratory; Wake & sleep EEG/spectral analysis, on-line physiology (blood pressure, heart-rate, core and peripheral temperatures), actimetry, light treatment, melatonin, feeding behaviour, psychiatric in- and outpatient studies (e.g., SAD); Undergraduate Research Projects (for MD candidates); Post-doctoral visitors welcome, grants must be applied for.

5. Types Of Funding Available: None routinely; only project-related

6. Number and Names Of Current Trainees: (1)

Christian Cajochen, Ph.D., Post-doc from the Institute of Pharmacology, University of Zurich on a Swiss NSF grant
Esther Werth, Ph.D., Post-doc from the Institute of Pharmacology, University of Zurich on a Swiss NSF grant

7. Students Who Have Completed Training In The Past Five Years and Current Status :

Janis Anderson, Ph.D.  Clinical Psychologist      Dept of Psychiatry, Harvard University, Boston, MA
Daniel Brunner, Ph.D.   Sleep Specialist       Clinic for Sleep Medicine Zurzach, Switzerland
John Kruse, M.D., Ph.D.   Psychiatrist       Langley Porter Psychiatric Institute, San Francisco CA
Lothar  Sand, M.D.  Psychiatrist       Psychiatric University Policlinic Zurich
Peter van der Velde  Graduate Student       University of Calgary,Canada
Asita Sarrafzadeh, M.D.  Physician        No information provided
Thomas Bruehl, M.D.  Psychiatrist        University of Frankfurt
Hans-Joachim Haug, M.D. Psychiatrist       Senior psychiatrist, Psychiatric University Clinic, Basel
Julie Schulman, B.Sc.   Medical Student       Cornell University
Georg Leonhardt, M.D.  Neurologist/Psychiatrist      Senior neurologist, Neurologic University Clinic Hessen
Konstantin Danilenko, M.D. Physician/Physiologist      Russian Academy of Sciences, Novosibirsk
Christian Cajochen, Ph.D. Sleep Researcher      Division of Endocrinology, Harvard Medical School, Boston

8. Primary Research Focus Of Laboratory :

Novel chronobiologic treatments for sleep and mood disorders; using the Constant Routine Laboratory to study putative zeitgebers (e.g.  light, melatonin, macronutrients, locomotor activity) and their effects on temperature regulation, heart-rate, wake & sleep EEG, spectral analysis
 
9. Technical Capabilities Of The Lab:

      +  Two constant routine research labs with temperature/ light/soundproofed rooms
      +  On-line data collection via computer / Nihon Kohden
      +  Programs for automated power spectral analyses
      +  Physiology: on-line blood pressure, heart rate, core and peripheral temperatures
      +  Psychometric / performance testing
      +  15 wrist actometers;  2 light monitors
 
10. Primary Training Focus:

Post-doctoral training in chronobiology and sleep regulation (Psychiatric Disorders emphasis)

11. Other Training Opportunities:

No information

12. Representative Publications For Last Five Years:

Cajochen, C., Kraeuchi, K., Moeri, D., Graw, P., & Wirz-Justice, A. (1997).  Melatonin and S-20098 phase advance REM sleep propensity and the wake-up threshold without modifying NREM-sleep homeostasis.  American Journal of Physiology, in press.

Graw, P., Gisin, B., & Wirz-Justice, A. (1997).  Follow-up study of seasonal affective disorder in Switzerland.  Psychopathology,
in press.

Kraeuchi, K., Reich, S., & Wirz-Justice, A. (1997).  Eating style in seasonal affective disorder:  Who will gain weight in winter?
Comprehensive Psychiatry, 38:80-87.

Kraeuchi, K., Cajochen, C., Moeri, D., Graw, P., & Wirz-Justice, A. (1997).  Melatonin and S-20098 advance circadian phase
and nocturnal regulation of core body temperature.  American Journal of Physiology, in press.

Kraeuchi, K., Cajochen, C., & Wirz-Justice, A. (1997).  A relationship between heat loss and sleepiness:  Effects of postural
change and melatonin administration.  Journal of Applied Psychology, in press.

Lam, R., Terman, M., & Wirz-Justice, A. (1997).  Light therapy for depressive disorders:  Indications and efficacy.  In A.J. Rush
(Ed.), Modern Problems in Pharmacopsychiatry:  Clinical Decision Trees in the Pharmacotherapy of Mood Disorders, in press.

Wirz-Justice, A., Rem, C.E., Pr nte, A., Heinen, U., Graw, P., & Urner, U. (1997).  Lithium decreases retinal sensitivity, but this is not cumulative with years of treatment.  Biological Psychiatry, 4, in press.

Wirz-Justice, A., Cajochen, C., & Nussbaum, P. (1997).  A schizophrenic with an arrhythmic circadian rest-activity cycle.
Psychiatry Research,  in press.

Brunner, D. P.,  Kraeuchi, K.,   Dijk, D.-J., Leonhardt, G., Haug, H.-J.,  &  Wirz-Justice, A. (1996). The sleep EEG in seasonal affective disorder and in control women:  effects of midday light treatment and sleep  deprivation.  Biological Psychiatry, 40:485-496.

Cajochen, C., Kraeuchi, K., von Arx, M., Moeri, D., Graw, P., & Wirz-Justice, A. (1996).  Daytime melatonin administration enhances fatigue and theta/alpha activity in the waking EEG.  Neuroscience Letters, 207:209-213.

Cajochen, C., K. Kraeuchi, D. Moeri, C. Hetsch & A. Wirz-Justice: A single administration of melatonin or the melatonin agonist S-20098 lengthens the first REM sleep episode.  Sleep Research  24 (1995)  p. 40.

Cajochen, C., Brunner, D.P., Kraeuchi, K., Graw, P. & Wirz-Justice, A. (1995) Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness.  Sleep, 18: 890-894.

Rosenwasser, A.M., & Wirz-Justice, A. (1996).  Circadian Rhythms and depression:  Clinical and experimental models.  In P.H. Redfern and B. Lemmer (Eds.), Handbook of Experimental Pharmacology:  Physiology and Pharmacology of Biological Rhythms.   Springer Verlag, Wien, Vol. 125, pp. 457-486.

Wirz-Justice, A., Graw, P., Kraeuchi, K., Sarrafzadeh, A., English, J., Arendt, J., & Sand, L. (1996).  ‘Natural’ light treatment of seasonal affective disorders.  Journal of Affective Disorders, 37:109-120.

Wirz-Justice, A. (1996).  Seasonal affective disorder and light therapy.  In: B. Lemmer (Ed.), From Circadian Clocks to Chronopharmacology.  Medpharm Scientific Publications, Stuttgart, pp. 189-200.

Wirz-Justice, A., & Armstrong, S.A. (1996).  Melatonin:  Nature’s soporific?  Journal of Sleep Research, 5: 1137-141.

Zulley, J., & Wirz-Justice, A. (Eds.).  Lichttherapie. S. Roderer Verlag, Regensburg.  Second Edition, 1996.

1. Affiliation: 1996-1997 Entry -  Department of Psychology, Brock University, CANADA

2. Name: Robert D. Ogilvie, Ph.D.

Brock University - Department of Psychology
St. Catherines, Ontario L2S 3A1 Canada 


Phone: (905)-688-5550 X3573;
FAX: (905)-668-6922;
E-Mail: rogilvie@spartan.ac.brock.u.ca

3. Other Faculty:

Kathryn Belicki (Psychology Department, Dreams and Nightmares)
Harry Hunt (Psychology Department, Dream Typology)
Peter Ramm (Psychology Department, Basic sleep mechanisms - animal research)

4. Types Of Training Available:
 

5. Types Of Funding Available:
 

6. Number and Names of Current Graduate Students
 

7. Students Who Have Completed Training In The Past Five Years and Current Status:

1995:
Sheri Allen, M.A. Dalhousie, Halifax, N.S.
Christi Alloway, Ph.D., Queen's University, Kingston, Ont.
Carole Lamarche, Ph.D., Queen's University, Kingston, Ont.
Tim Murphy, M.A., T.A. & R.A., Brock University

1994:
S. Bowman, .Sc. U. Western Ontario
Lisa Chilcott, M.Sc. - U. Toronto
Ken Leslie, B.A. Waterloo; Ph.D. student, Brandeis
Simon Kelly, M.Sc. Brock University

1993:
Robin Battye, M.A. Carleton University (Ottawa), Ph.D. McMaster University
Kimberly Cote M.A. University of Toronto, Ph.D., University Ottawa

8. Primary Research Focus Of Laboratory:

+ Sleep Onset
+ Insomnia
+ Psychophysiology of sleep
+ Behavioral Sleep/Wake Monitoring
+ Sleep deprivation and performance

9. Technical Capabilities Of The Lab:

* Excellent facilities: 2 sleep rooms off of main sleep recording room; washroom and computer analysis room(all in a soundproof / RF shielded environment).
* 2 EEG machines; 3 computers with MQE sleep/ERP analysis capability (very high level research flexibility)
* Data acquisition and analysis program (sleep scoring, spectral analysis, ERP analysis)

10. Primary Training Focus:

Sleep ressearch is a focus of the department within our Behavioural Neuroscience Graduate Program. Other foci are in Social Personality and Cognitive/Developmental Psych.

11. Other Training Opportunities:

Collaboration with Sleep Disorders Clinic in Niagara Falls, Canada.

12. Representative Publications For Last Five Years: (Ogilvie Lab only)

Chapters:

Cote, K.A., & Ogilvie, R.D. (1995). Behavioral home monitoring in insomniac and normal sleepers. Canadian Journal of Behavioral Science, 27, 438-449.

Bowman, S.K., Jamieson, D.G. & Ogilvie, R.D. (1995). Waking effectiveness of visual alerting signals. Journal of Rehabilitation Research and Development. 32, 43-54.

Cote, K.A. & Ogilvie, R.D. (1994). Identifying sleep and wakefulness: A comparison of behavioural and polysomnographic methods. Journal of Psychophysiology, 8, 305-313.

Ogilvie, R.D., Battye, R.A. & Simons, I.A. (1994). Changing CNS priorities in sleepiness and sleep? EEG and ERP evidence. In: R.D. Ogilvie & J.R. Harsh (Eds.) Sleep Onset: Normal and Abnormal Processes. Washington D.C.: American Psychological Association.

Ogilvie, R.D. & Simons, I.A. (1992). Falling asleep and waking up: acomparison of EEG spectra. In R. Broughton & R Ogilvie (Eds.). Sleep, arousal and performance. Boston: Birkhauser.

Broughton, R.J. & Ogilvie, R.D. (1992). Sleep, Arousal and Performance: An Outline. In R.Broughton & R Ogilvie (Eds.). Sleep, arousal and performance. Boston: Birkhauser.

Segalowitz, S.J., Ogilvie, R.D., & Simons, I.A. (1990). An ERP state measure of arousal based on behavioural criteria. In J.A. Horne (Ed.) Sleep'90. Bochum: Pontenagel Press.

Hunt, H.T, & Ogilvie, R.D. (1988). Lucid dreams in their natural series: Phenomenological and psychophysiological findings in relation to meditative states. In Gackenbach, J. & LaBerge, S. (Eds.). Lucid dreaming: New research on consciousness during sleep. New York: Plenum.

Refereed Journals:

Cote, K.A., & Ogilvie, R.D. (1995). Behavioral home monitoring in insomniac and normal sleepers. Canadian Journal of Behavioral Science, 27, 438-449.

Bowman, S.K., Jamieson, D.G. & Ogilvie, R.D. (1995). Waking effectiveness of visual alerting signals. Journal of Rehabilitation Research and Development. 32, 43-54.

Cote, K.A. & Ogilvie, R.D. (1994). Identifying sleep and wakefulness: A comparison of behavioural and polysomnographic methods. Journal of Psychophysiology, 8, 305-313.

Kuderian, R.H., Ogilvie, R.D., McDonnell, G., and Simons, I.A. (1991). Behavioral response home monitoring of good and insomniac sleepers. Canadian Journal of Psychology, 45(2), 169-178.

Ogilvie, R.D., Simons, I.A., Kuderian, R.H., MacDonald, T., & Rustenburg, J. (1991). Behavioral, event-related potential (ERP), and EEG/FFT changes at sleep onset. Psychophysiology, 28 (1).

1. Affiliation: 1997-1998 Entry - Dalhousie University, CANADA, Department of Anatomy and Neurobiology

2. Name & Address: Kazue Semba, Ph.D.

Department of Anatomy and Neurobiology
Dalhousie University
Halifax, Nova Scotia, Canada B3H 4H7

Phone: 902-494-2008;
FAX: 902-494-1212;
E-Mail: semba@is.dal.ca

3. Other Faculty:

Over 40 members of the Institute of Neuroscience whose research interests include sleep and biological rhythms.

4. Type Of Training Available:

We are involved in training at the undergraduate (honours theses), graduate (M.Sc., Ph.D. in Neuroscience) andpostdoctoral levels. The Neuroscience Graduate Program offers comprehensive training in neuroscience.

5. Types Of Funding Available:

Students are encouraged to apply for studentships from external agencies. Support is also available from the departmentand the university.

Type of funding (laboratory grants):  Medical Research Council of Canada, Scottish Rite Charitable Foundation

6. Number and Names Of Current Trainees:

4 Neuroscience/Anatomy students (1 Ph.D. and 2 M.Sc.)

Graduate students: William Fortin, Hilary Bennett, Leticia Materi.

7. Students Who Have Completed Training In The Past Five Years and Current Status:

8. Primary Research Focus Of Laboratory :

+ Cholinergic and adenosinergic mechanisms of sleep and wakefulness.
+ Circadian rhythms and sleep.

9. Technical Capabilities Of The Lab:

* Electrophysiology lab with multiple EEG & unit recording capabilities
* BrainWave system for data acquisition and analysis.
* Full histology lab for immunohistochemistry, in situ hybridization, tract tracing, image analysis.
* Currently setting up for microdialysis in anesthetized and freely moving animals.

10. Primary Training Focus: Graduate training in neuroscience.

11. Other Training Opportunities:

Courses offered by the Departments of Psychology, Physiology and Biophysics, Pharmacology and Biochemistry of Dalhousie University. Co-supervision by a faculty in any of these department may also be arranged.

12. Representative Publications For Last Five Years:

Luebke, J.I., Greene, R.W., Semba, K., McCarley, R.W., Kamondi, A. and Reiner, P.B. (1992) Serotonin hyperpolarizes cholinergic low threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro.  Proc. Nat. Acad. Sci. U.S.A., 89:
743-747.

Honda, T. and Semba, K. (1995) An ultrastructural study of cholinergic and non-cholinergic neurons in the laterodorsal and pedunculopontine tegmental nuclei in the rat.  Neuroscience, 68: 837-853.

Inglis, W.L. and Semba, K. (1996) Colocalization of ionotropic glutamate receptor subunits with NADPH-diaphorase-containing neurons in the rat mesopontine tegmentum.  J. Comp. Neurol. 368:17-32.

Detari, L., Rasmusson, D.D. and Semba, K. (1997) Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat. Brain Res., in press.

Detari, L., Semba, K. and Rasmusson, D.D. (1997) Responses of cortical EEG-related basal forebrain neurons to brainstem and sensory stimulation in urethane-anesthetized rat. Eur. J. Neurosci., in press.

1. Affiliation: 1996-1997 Entry -  Department of Physiology - Eötvös Loránd University

2. Name & Address: Gabor Juhasz

Hungary, Budapest, 1088. Muzeum Krt.
Phone: (36)-1-266-1154;
E-Mail: gnyitral@ludens.elte.hu

3. Other Faculty: No information provided.

4. Types of Training Available:

In vivo microdialysis, HPLC technics for amino acid, ions, catecholamines and a special HPLC system (SMART) for UV detectable metabolites, electrophysiology

5. Types Of Funding Available: National Science Foundation

6. Number and Names Of Current Trainees: (1) Bryan Leonard (USA)

7. Students Who Have Completed Training In The Past Five Years and Current Status:

(1) Wilhelm Drinkenburs (The Netherlands)

8. Primary Research Focus of Laboratory: Neurochemistry, state dependent changes

9. Technical Capabilities: Pharmacia LKB HPLC systems: UV detector, SMART for peptides , gradiant system with fluorescent detector for amino acid analization, electrochemical detector for catecholamines, conductance detector for ions. Complete recording site for electrophysiology (Grass EEG, CED, biostimulator, PC 486....). To use microdialysis there are two different site for surgery and collect samples (Stoelting stereotaxic frame using Halothane anaesthesia).

10. Primary Training Focus: Invivo microdialysis, HPLC

11. Other Training Opportunities: Electrophysiology

12. Representative Publications For Last Five Years:

Juhasz, G., Tarcali, J., Pungor, K., Pungor, E.: Electrochemical calibration of in vivo brain dialysis samplers. J. of Neurosci. Methods, 29: 131­137, 1989.

Juhasz, G., Emri, Zs, Kikesi, K., Pungor, K.: Local perfusion of the thalamus with GABA increases sleep and long-lasting inhibition of somatosensory event­related potentials in cats. Neurosci. Lett. 103: 229­233, 1989.

Juhasz, G., Emri, Zs., Kikesi, K., Pungor, K.: Perfusion of thalamic relay nuclei with GABA promotes sleep. In Diencephalon and Sleep. Ed. G. Marini Raven, pp 361­366, 1990.

Juhasz, G., Kikesi, K., Emri, Zs., Soltisz, I., Crunelli, V.: Sleep promoting action of excitatory amino acid antagonists: A different role of action of thalamic NMDA and nonNMDA receptors? Neurosci. Lett. 114: 333­338, 1990.

Pungor K., Papp M., Kikesi K., Juhasz, G.: A novel effect of MPTP: the selective suppression of paradoxical sleep in cats. Brain Res. 525: 310­314, 1990.

Juhasz, G., Kikesi, K., Emri, Zs., Soltisz, I., Crunelli, V.: Thalamic excitatory and inhibitory amino acid receptors play different roles in the modulation of sleep. In: Sleep` 90. Ed. J. Horne, Oibtenagel Press, pp 1­4, 1990.

Gratzl,M., Tarcali, J., Pungor, E., Juhasz, G.: Local depletion of monoamines induced with in vivo voltammetry in the cat brain. Neuroscience 41: 287­293, 1991

Juhasz, G., Kikesi, A.K., Emri, Zs., Ujszaszi, J., Krogsgaard­Larsen, P., Schousboe, A. Sleep promoting effect of a putative glial j­aminobutyric acid uptake blocker applied in the thalamus of cats. Eur. J. Pharmacology. 209: 131­133, 1991.

G. Juhasz, A.K. Kikesi, K. Pungor, I. Slezsak: Measurement of microdialysis samples by electrochemical and fluorescent detectors In Bioelectroanalysis II: Akadimiai Kiads. Budapest. 1992. 59­74.

K. Pungor, A. Hajnal, K. A. Kikesi, G. Juhasz: Paradoxical sleep deprivatory effect of a single low dose of MPTP which did not produce dopaminergic cell loss Exp. Brain Res. 95: 473­476, 1993.

R. Galambos, G. Juhasz, A.K. Kikesi, G. Nyitrai, N. Szilagyi: Natural sleep modifies the rat electroretinogram, Proc. Natl. Acad.Sci. USA accepted, 14.03.1994.

1. Affiliation: 1996-1997 entry - Department of Physiology, School of Medicine, National University of Mexico

2. Name & Address: René Drucker-Colín

Depto. de Fisiología
Facultad de Medicina, UNAM
Apdo. Postal 70-250, 04510 México, D.F.

Phone: (52)-5-550-29-20
FAX: (52)-5-623-22-41

3. Other Faculty:

- Rafael Salín-Pascual (Physiology) - Oscar Prospéro-García (Physiology)
- José María Calvo (Psychiatry) - Augusto Fernández-Guardiola (Psychology and Psychiatry)
- Raúl Aguilar-Roblero (Biological Rhythms)

4. Type Of Training Available:

* Graduate training: There is graduate training available, however, no financial support for non Mexican citizens.
* Postdoctoral: Financial aid for anyone.

5. Types Of Funding Available: Funding is available for 2 years for postdoctoral students

6. Number and Names Of Current Trainees: (9)

Graduate students

- Luis Beltrán-Parrazal
- Carlos Blanco-Centurión
- Fabio García-García
- Anabel Jiménez-Anguiano
- Jacqueline Vázquez

Medical students

- Rubén Guzmán Marín
- María Dolores Martínez González
- María Luisa Moro-López
- Paul Shkurovich

7. Students Who Have Completed Training In The Past Five Years and Their Current Status.

Rafael Jesús Salín-Pascual. M.D., Ph.D. (Medical Sciences) 1991.
Current position: Professor at the Department of Physiology, School of Medicine in the National University of Mexico.

Antonio Ysunza-Rivera. M.D., Ph.D. (Medical Sciences) 1992.
Current position: Physician in the Hospital Manuel Gea González.

Juan Fernández-Ruiz. Ph.D. in Neuroscience 1993.
Current position: Post­doctoral trainee. Laboratory of Neuropsychology, NIMH Bethesda, MD. USA.

Fernando García-Hernández. Ph.D. in Neuroscience 1993.
Current position: Associate Professor in the Dept. of Physiology, ENEP­Iztacala, UNAM. México, D.F.

Esteban José Luis Mendoza-Ramírez. Ph.D. in Neuroscience 1995.
Current position: Post-doctoral trainee. Genentech. San Francisco, CA. USA

8. Primary Research Focus Of Laboratory

- Neurophysiology of Sleep
- Molecular Biology and Sleep
- Neuropharmacology of Sleep

9. Technical Capabilities Of The Laboratory

Facilities of the laboratory are mostly in Basic Research

- Polygraphs EEG recording - Tissue culture lab
- Electrophysiology - HPLC
- Power spectral analysis - Microdialysis
- Single unit recordings - Image analysis
- Immunohistochemistry - Histology
- Stereotaxic equipment for rats and cats

As of 1997 we will have a sleep disorders clinic, here at the Medical School and facilities for recording 4 patients simultaneously.

10. Primary Training Focus: Ph.D. in Physiology

11. Other Training Opportunities: No information provided.

12. Representative Publications For Last Five Years:

Lavín, M.A. and Drucker­Colín, R. Ontogeny of the electrophysiological activity of dopaminergic cells with special reference to the influence of adrenal medullary grafts on aging. Brain Research 545: 164­ 170, 1991.

Salín­Pascual, R.J., Granados­Fuentes, D,. De la Fuente, J.R and Drucker­Colín, R. Effects of auditory stimulation during rapid eye movement sleep in healthy volunteers and depressed patients. Psychiatry Research 38:237­ 246, 1991.

Mendoza­Ramírez, J.L., Aguilar­Roblero, R., Zainos­Rosales, A. and Drucker­Colín, R. Fetal substantia nigra and adrenal medullary grafts placed contralateral to the nigrostriatal lesion side induce a decrease in turning behavior but not in dopamine receptor density. Restorative Neurology and Neuroscience 3:177­185, 1991.

Salín­Pascual, R.J., Jiménez­Anguiano, A., Granados­Fuentes, D. and Drucker­Colín, R. Effects of Biperiden on sleep at baseline and after 72 h of REM sleep deprivation in the cat. Psychophharmacology 106: 540­542, 1992.

Merchant­Nancy, H., Vázquez, J., Aguilar­Roblero, R. and Drucker­Colín, R. c­fos proto­oncogene changes in relation to REM sleep duration. Brain Research 579:342­346, 1992.

Aguilar­Roblero, R., Shibata, S., Speh, J.C., Drucker­Colín, R. and Moore, R.Y. Morphological and functional development of the suprachiasmatic nucleus in transplanted fetal hypothalamus. Brain Research 580: 288­296, 1992.

Aguilar­Roblero, R., Drucker­Colín, R. and Moore, R.Y. Behavioral and morphological studies of fetal neural transplants into SCN­lesioned rats. Chronobiology International 9:278­298, 1992.

Prospéro­García, O., Jiménez­Anguiano, A. and Drucker­Colín, R. The combination of VIP and atropine induces REM sleep in cats rendered insomniac by PCPA. Neuropsychopharmacology 8: 387­390, 1993.

Prospéro­García, O., Jiménez­Anguiano, A. and Drucker­Colín, R. Chloramphenicol prevents carbachol­induced REM sleep in cats. Neuroscience Letters 154: 168­170, 1993.

Zainos­Rosales, A., Aguilar­Roblero, R., Mendoza­Ramírez, J.L. and Drucker­Colín, R. 2­Deoxyglucose autoradiographic evidence that substantia nigra grafts in 6­hydroxydopamine lesioned animals produce recovery of motor asymmetries by exerting contralateral effects. Neuroscience Letters 156: 99­104, 1993.

Jiménez­Anguiano, A., Báez­Saldaña, A. and Drucker­Colín, R. Cerebrospinal fluid (CSF) extracted immediately after REM sleep deprivation prevents REM rebound and contains vasoactive intestinal peptide (VIP). Brain Research 631: 345­348, 1993.

Salín­Pascual, R.J., Jiménez­Anguiano, A., Durán­Vázquez, A., Merchant Nancy, H. and Drucker­Colín, R. Administration of auditory stimulation during recovery after REM sleep deprivation. Sleep 17: 231­235, 1994.

Islas­Suárez, L., Gómez­Chavarín, M., Drucker­Colín, R. and Hernández­Cruz, A. Properties of the sodium current in rat chromaffin cells exposed to Nerve Growth Factor in vitro. Journal of Neurophysiology 72: 1938-1948, 1994.

Drucker­Colín R., Verdugo­Díaz L., Méndez M., Carrillo­ Ruiz J., Morgado­Valle C., Hernández­Cruz A. and Corkidi, G. Compa-rison between low frequency magnetic (LFM) field stimulation and nerve growth factor (NGF) treatment of cultured chromaffin cells, on neurite growth, noradrenaline release, excitable properties and grafting in nigro­striatal lesioned rats. Molecular and Cellular Neurosciences 5:485-498, 1994.

Drucker-Colín, R. The function of sleep is to regulate brain excitability in order to satisfy the requirements imposed by waking. Behavioral Brain Research 69: 117-124, 1995.

Merchant-Nancy, H., Vázquez, J., García, F. and Drucker-Colín, R. Brain distribution of c-fos expression as a result of prolonged rapid eye movement (REM) sleep period duration. Brain Research 683:15-22, 1995.

Salín-Pascual, R.J., De la Fuente, J.R., Galicia-Polo, L. and Drucker-Colín, R. Effects of transdermal nicotine on mood and sleep in nonsmoking major depressed patients. Psychopharmacology 121:476-479, 1995.

Mendoza-Ramírez, J.L., Beltrán-Parrazal, L., Verdugo-Díaz, L., Morgado-Valle, C. and Drucker-Colín, R. Delay in manifestations of aging by grafting NGF cultured chromaffin cells in adulthood. Neurobiology of Aging 16:907-916, 1995.

1. Affiliation: 1997-1998 Entry - Flinders University - School of Psychology and Sleep Disorders Unit

2. Name & Address: Leon C. Lack, Ph.D.

Flinders University - School of Psychology
GPO Box 2100
Adelaide, South Australia 5001 Australia

Phone: 618-8201-2391; FAX: 618-8201-3877
E-Mail: leon.lack@flinders.edu.au

3. Other Faculty: No information provided.

4. Type Of Training Available: Undergraduate and post graduate courses, Psychophysiology of States of Awareness (circadian rhythms and sleep), Sleep and Arousal Disorders and therapies.

5. Types Of Funding Available  (Trainee Support): Possibility of graduate student scholarship for a Psychology 'Honors graduate' or M.A./M.S. degree holder. Some research assistant money and part­time teaching money often available but dependent on time of year and merits of applicant.

6. Types Of Funding Available (Laboratory Grants):  NHSMRC and ARC external research grants

7. Number and Names Of Current Trainees:

Graduate students: Kurt Lushington, Helen Wright, Jeremy Mercer.

8. Students Who Have Completed Training In Last Five Years and Current Status:
 

9. Primary Research Focus Of Laboratory:
 

10. Technical Capabilities Of The Lab:

+ Three bedroom sleep research lab, each with 4­channel amplifiers, input through A/D converter toMacintosh computer run with LabView software system.
+ Two portable complete 16 channel PSG recording systems (Compumedics) for home or laboratory recording.
+ Fifteen actigraph wrist/ankle motion sensors for ambulatory sleep and activity monitoring.
+ Eight ambulatory Vitalog activity and temperature monitors.
+ Reaction time response monitoring for two sleeping subjects.
+ A four channel laboratory temperature (rectal and skin) amplifier input to the Mac and LabView computer software analysis system.

11. Primary Training Focus: Behavioral and bright light treatments for insomnia, circadian rhythms and sleep interactions, information processing during sleep.

11. Other Training Opportunities: No information provided.

12. Representative Publications For Last Five Years:

Lack, L.C. & Thorn, S.J. (1992)  Sleep disorders: Their prevalence and behavioral treatment.  In G.R. Caddy and D.G. Byrne (Ed..), Behavioral medicine: International Perspectives, Volume 2. pp 347-395, Norwood, New Jersey: Ablex Publishing Corporation.

Morris, M., Lack, L. & Dawson, D. (1990). Sleep-onset insomniacs have delayed temperature rhythms.  Sleep  13, 1-14.

Morris, M., Lack, L. & Barrett, J. (1990). The effect of sleep/wake state on nocturnal melatonin excretion.  Journal of Pineal Research   9, 133-138.
 
Barrett, J., Lack, L., & Morris, M. (1993). The sleep evoked decrease of body temperature.  Sleep   16, 93-99.

Dawson, D., Lack, L. & Morris, M. (1993).  Phase resetting of the human circadian pacemaker using a single pulse of bright light.  Chronobiology International   10, 94-102.

Lack, L. & Wright, H. (1993). The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs.  Sleep   16, 436-443.

1. Affiliation: 1995-1996 Entry - University of Manitoba, St. Boniface Hospital

2. Name & Address: Meir H. Kryger

St. Boniface Hospital
351 Tache Avenue, Room R2034
Winnipeg, MB R2H 2A6, Canada

Phone: (204) 235-3406
FAX: (204) 235-0021;
E-Mail: kryger@sleep1.sleep.uman.toba.ca

3. Other Faculty:: Dr. Sat Sharma

4. Types Of Training Available:

* Clinical research 1 to 2 year fellowship
* Shorter rotations available

5. Types Of Funding Available:

For foreign graduates, funds are usually from home country. Canadians funded through university.

6. Number and Names Of Current Trainees: (1) Siraj Wali

7. Students Who Have Completed Training In The Past Five Years and Current Status : (3)
 

8. Primary Research Focus Of Laboratory : Sleep in health and disease

9. Technical Capabilities Of The Lab:

* 4 bedrooms
* 3 grass 78E
* 1 grass 78D
* Ear SAO₂ & ETCO₂
* Computerized apnea analysis

10. Primary Training Focus: Sleep apnea and heart disease.

11. Other Training Opportunities: No information given.

12. Representative Publications For Last Five Years:

Yamashiro Y, Kryger MH (1993). Renew: Sleep in heart failure. Sleep, 16:6:513-523.

Biberdorf DJ, Steen R, Millar TW, Kryger MH. Benzodiazepines in congestive heart failure: effects of temazepam on arousability and cheyne-Stokes respiration. Sleep, 16:6:529-538.

Kerr P, Shoenut JP, Steens RD, Millar T, Micflikier AB, Kryger MH. Nasal CPAP: A new treatment for nocturnal gastroesophageal reflux. J Clin Gastroente, 17:4:276-280; 1993.

Steens RD, Pouliot Z, Millar TW, Kryger MH, George CF (1993). Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonar disease. Sleep, 16:3:318-326.

Kryger MH (1993). Snoring: a public health hazard. Chest, 104:1:2-3.

Alvaro RE, De-Almeida V, Kwiatkowski K, Cates D, Kryger MH, Rigatto H (1993). A developmental study of the dose-response curve of the respiratory sensory reflex. Amer Rev Respir Dis, 148:4pt1:1013-1017.

Gall R, Isac L, Kryger MH (1993). Quality of life in mild obstructive sleep apnea. Sleep, 16:8S:S59-S61.

Kryger MG, Roth T, Carskadon M. Circadian rhythms in humans: an overview. In Kryger MH, Roth T, Dement WC (Eds). Principles and Practice of Sleep Medicine, 2nd Edition. Philadelphia: W.B. Saunders Co., 1994. pp. 301-308.

Kryger MH. Management of obstructive sleep apnea: an overview. In Kryger MH, Roth T, Dement WC (Eds). Principles and Practice of Sleep Medicine, 2nd Edition. Philadelphia: W.B. Saunders Co., 1994. pp. 736-747.

Yamashiro Y, Kryger MH (1994). Acute effect of nasas on CPAP on periodic limb movements associated with breathing disorders during sleep. Sleep, 17:2:172-175.

Steens RD, Millar TW, Su X, Biberdorf D, Buckle P, Ahmed M, Kryger MH (1994). Effect of inhaled 3% CO2 on Cheyne-Stokes respiration in congestive heart failure. Sleep, 17:1:61-68.

Yamashiro Y, Kryger MH (1994). Why should sleep apnea be diagnosed and treated. Clin Pulm Med, 1:250-259.

Yamashiro Y, Kryger MH (1994). Acute effect of nasal continous positive airway pressure on periodic limb movements associated with beathing abnormalities during sleep. Sleep, 17:172-175.

Yamashiro Y, Kryger M (1995). CPAP titration for sleep apnea using slit-night protocol. Chest, 107:62-66.

Wilkins MA, Xiao-Ling S, Palayew M, Bolli P, McKenzie JK, Yamashiro Y, Kryger MH. The effects of posture change and continous positive airway pressure on cardiac natriuretic peptided in congestive heart failure. Chest, (in press).

ATS Task Force (M. Kryger, member). Sleep apnea, sleepiness and driving risk. Official statement of the American Thoracic Society. Am Rev Respir Dis, 150:1643-1673.

Lertzman M, Kryger M (1995). Fitness to drive in te elderly (letter). Lancet, 345-364.

1. Affiliation: 1997-1998 Entry -  Department of Psychiatry, Department of Psychology, Neuroscience Program & Research Center, University of Montreal, Canada; Sacre-Coeur Hospital's Research Center Luois-H. Lafontaine Hospital's Research Center

2. Name & Address: Roger Godbout, Ph.D.

Centre de recherche Hopital du Sacre-Coeur
5400 Boul. Gouin ouest Montreal (Quebec)
Canada H4J 1C5

Phone (514) 338-2222, ext. 2462
FAX: 338-2694,
URL: = http://cyclone.ere.umontreal.ca/crfs/laboratoires/sommeil.html

3. Other Faculty:

I am a member of a sleep research group that is headed by Jacques Montplaisir, M.D., Ph.D.; other researchers are Marie Dumont, Ph.D.(circadian rhythms in humans); Gilles Lavigne, DMD., M.Sc. (motor behaviors in human sleep);  Tore A. Nielsen, Ph.D. (quantified EEG analysis; dream content analysis); Harry H. Webster , Ph.D. (sleep and neuronal plasticity).  All are attached to the Department of Psychiatry, Univertsity of Montreal except G.L. who's primary affiliation is at the Faculty of Dental Medicine, U. of Montreal.  The Research Centre at Louis-H. Lafontaine Hospital also hosts many research teams devoted to neurobiological psychiatry, including neuropsychology, evoked potentials, psychopharmacology, biochemical assays (autoradiography, binding, brain bank of human/animal tissue).

4. Type Of Training Available:

Research exclusively, but this may include the optional research training that is often available to students in clinical programs. Length and complexity of the research project can be adapted to academic level, i.e., from a short (4 months) exposure to research activities, to full training leading to a graduate degree, to postdoctoral level full research projects. Training is available at the following levels: Undergraduate, Graduate, Ph.D./MD Joint Program, Internship (human research only), Fellowship, Post-Doctoral.

5. Types Of Funding Available (Trainee Support):

- Candidates can apply to the many studentships/fellowships that are available on a competitive basis through the Medical
  Research Council of Canada (MRC/CRM), the National Science and Engeneering Research Council of Canada
  (NSERC/CRSNG), and the Fonds de la Recherche en Sante du Quebec (FRSQ). Deadlines take place during the fall of the
  previous year.
- The FRSQ funds a Mental Health Research Network that also provide a limited number of studentships/fellowships in sleep
  research. It is required that candidates also applied to MRC, NSERC or FRSQ regular contests.
- All affiliations (University and Hospitals) have a limited number of studentships/fellowships through various Trusts and
  Foundations.
- The lab itself cannot garantee funding to trainees this year but this is reconsidered each year.  Only Master's or Ph.D.
  studentship require a Canadian citizenship.

6.  Type of Funding Available (Laboratory Grants):
 

- National Science and Engeneering Research Council of Canada (NSERC/CRSNG)
- Fonds de la Recherche en Sante du Quebec (FRSQ)

7. Number and Names Of Current Trainees: (6):

Cybele Bergeron (M.Sc./M.D. program)
Isabelle Beaulieu (Neuropsychology)
Genevieve Forest (Neuropsychology)
Veronique Girodias (Experimental Psychology)
Lorraine Riopel (Neuroscience Program)
Hugo Tremblay (Biomedical Science)

8. Students Who Have Completed Training In The Past Five Years and Current Status: (1)

Patricia Jelenic   (Msc. Experimental Psychology)  Research Assistant in Behavioral Neuroscience

9. Primary Research Focus Of Laboratory:

 Neurobiological Psychiatry: neuropsychology, neuropharmacology and electrophysiology of vigilance states, both in animals and humans.

*IN RATS:

- Dopamine and sleep: unit recordings and effect of dopaminergic drugs in neuronal networks related to sleep; unit recordings and effects of hypnotics in the meso-cortico-limbic (dopaminergic) system; electrophysiological and behavioral circadian recordings (EEG, temperature, locomotion) in experimental models of psychiatric diseases, including acute/chronic treatment with psychotropic drugs.

- Selective sleep deprivation and performance, EEG, temperature, and motor activity.

*IN HUMANS:

- Schizophrenia and sleep: sleep-wake cycles, EEG analysis, dream content analysis and cognitive performance in drug-naive patients, before and after treatment.

- Selective sleep deprivation and cognitive performance in normals.
 
10. Technical Capabilities Of The Lab:

ANIMAL LABS:

- Eight (8) sleep recording cages equipped with automated temperature and locomotion recording systems, two 32 channels automated quantified electrophysiological (EEG, units, etc) recording systems;

- Acute unicellular electrophysiological laboratory under stereotaxic control (unit recording, stimulation, iontophoresis);

- Two (2) sleep deprivation units for rats;

- Behavioral measures equipment (Morris water maze, Serial alternation, Passive avoidance...).

HUMAN LABORATORY:

- Two (2) bedrooms each equipped with fully computerized (paperless) 16 channels recording system, automated (spectral and coherence analysis) and semi-automated (sleep staging) analysis system (shared);

- One (1) Data analysis station for sleep staging and spectral analysis;

- Neuropsychological testing (psychomotor performance, learning and memory, etc).

11. Primary Training Focus:

Biological Psychiatry and Neuroscience (Psychology, Psychiatry, Biology, Behavioral Science, etc.), fundamental and clinical.

12. Representative Publications For Last Five Years:

Pirot S, Godbout R, Mantz J, Tassin JP, Glowinski J, Thierry AM. Inhibitory effects of the ventral tegmental area stimulation on the activity of prefrontal cortical neurons: Evidence for the involvment of both dopaminergic and GABAergic components. Neuroscience 1992; 49: 857-865.

Montplaisir J, Godbout R, Pelletier G, Warnes H. Restless legs syndrome and periodic limb movements during sleep. In Kryger MH, Roth T, Dement WC, eds.  Principles and Practice of Sleep Medicine. Philadelphia: Saunders, 1993: 589-597.

Godbout R, Jelenic P, Labrie C, Schmitt M, Bourguignon JJ. Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on prefrontal cortex firing in the rat. Brain Research, 1995; 673: 157-160.

Stip E, Godbout R. Cortex prefrontal, monoamines et neuropsychologie de la schizophrenie. Medecine Sciences 1995; 11: 1531-1538.

Girodias V, Godbout R, Beaulieu I, Schmitt M, Bourguignon JJ, Webster HH.  Triggering of paradoxical sleep with gamma-hydroxybutyrate (GHB) in the rat is blocked by the GHB receptor antagonist NCS-382.  Sleep Research 1996; 25: 9.

Bergeron C, Godbout R, Mottron L, Stip E. Sleep and dreaming in Asperger's syndrome. Sleep Research 1997; 26: in press.

Morisson F, Descary A, Poirier G, Godbout R, Bedard MA, Lavigne G, Montplaisir J. Vigilance impairment in obstructive sleep apnea syndrome, idiopathic hypersomnia and narcoleysy. Sleep Research 1997; 26: in press.

Riopel LV, Forest G, Lussier I, Stip E, Godbout R. Performance on a selective attention task correlated with sleep organization in normal young subjects. Sleep Research 1997; 26: in press.

Tremblay H, Godbout R, Girodias V, Dallaire AC. Effects of gamma-hydroxybutyrate on ventral tegmental unit activity in the rat: preliminary results. Sleep Research 1997; 26: in press.

1. Affiliation: 1995-1996 Entry - Universite de Montreal, Department of Psychiatry

2. Name & Address: Jacques Y. Montplaisir, M.D., Ph.D.

Centre d'etude du Sommeil
Hospital du Sacre-Coeur
5400 boul. ouin Quest
Montreal, Quebec, Canada H4J 1C5

Phone: (514) 338-2693;
FAX: (514) 338-2531

3. Other Faculty: Marie Dumont, Ph.D.; Tore Nielsen, Ph.D.; Gilles Lavigne, D.M.D.; Roger Godbout, Ph.D.; Harry Webster, Ph.D.

4. Types Of Training Available:

* Three to five years studentship (MSc or PhD)
* Postdoctoral trainees

5. Types Of Funding Available:

MRC, Studentship for graduate students (MSc or PhD) stipends = 15,000.$cn
FCAR, studentship for graduate students (MSc or PhD) stipends = 14,000.$cn
FRSQ, studentship for graduate students (MSc or PhD) stipends = 14,000.$cn
FRSQ and CRMC funded postdoctoral fellowships ­ stipends range 22,500.$cn

Studentship for graduate students are limited to canadian citizen but postdoctoral fellowship are open to candidate from other countries. Deadline for application take place at various time during the fall of the previous year.

6. Number and Names Of Current Trainees: (J.Y. Montplaisir only):
 

7. Students Who Have Completed Training In The Past Five Years and Current Status:

Tore Nielsen, Ph.D. Assistant Professor of Psychiatry Univ. Montreal
Dominique Lorrain, Ph.D. Assistant Professor of Psychology Univ. of Sherbrooke
Marc­Andre Bedard, Ph.D. Assistant Professor of Psychology Univ. du Quebec Montreal
Dominique Petit, Ph.D. Research Associate Hop.Sacre­Coeur, Sleep Dis Lab
Diane Boivin, MD, Ph.D. Postdoctoral fellow Harvard Medical School

8. Primary Research Focus Of Laboratory:
 

9. Technical Capabilities Of The Lab:

+ Five rooms for polysomnographic recordings
+ Can study up to 6 patients nightly
+ Time­isolation facility (constant routine)
+ Period/analysis, quantitative EEG, brain mapping and study of dopaminergic ligands in SPECT
+ Basic neurophysiology and neuropharmacology

10. Primary Training Focus:

Postdoctoral research training in sleep disorders, dreams, and biological rhythms research.

11. Other Training Opportunities:

The Centre d'etude du Sommeil provides an integrated courses (45 hrs) on sleep, dreaming and biological rhythm. The candidate can also attempt the regular seminars in the departments of psychology, neurosciences and psychaitry at the Universite de Montreal, depending on their own professional interest.

12. Representative Publications For Last Five Years:

Montplaisir J, Godbout R, Pelletier G, Warnes H. Restless legs syndrome and periodic limb movements during sleep. In: MH Kryger, T Roth, WC Dement (eds). Principles and Practice of Sleep Medicine. NY:Saunders, 1993:589­597.

Lavigne G, Montplaisir J. Bruxism: Epidemiology, Diagnosis, Pathophysiology, and Pharmacology. In: JR Fricton and R Dubner (Eds), Orofacial Pain and Temporomandibular Disoders, NY:Raven Press, 1995;23:387­404.

Godbout R, Jelenic P, Labrie C, Schmitt M, Bourguignon JJ. Effect of gamma­ hydroxybutyrate and its antagonist NCS­382 on prefrontal cortex diring in the rat. Brain Research 1995;673:157­160.

Czeisler CA, Dumont M, et al. Association of sleep­wake habits in older people with changes in output of circadian pacemaker. The Lancet 1992;340:933­936.

Nielsen TA, Dumont M, Montplaisir J. Twenty hours of continuous recovery sleep: a case study of sleep rebound and dream incorporation after a 10­day film marathon. Journal of Sleep Research, 1995: in pres

1. Affiliation: 1997-1998 Entry - University of Montreal, Department of Psychiatry - Dream & Nightmare Laboratory, Sacred Heart Hospital

2. Name & Address Tore A. Nielsen, Ph.D.

Centre d'etude du sommeil
Hospital du Sacre-Coeur
5400 Boulevard Gouin Quest
Montreal, Quebec Canada H4J 1C5

Phone: (514) 338-2222  ext. 3350
FAX: (514) 338-2351;
E-Mail:nielsen@ereumontreal.ca

3. Other Faculty:

Jacques Montplaisir, M.D., Ph.D.; other researchers are Marie Dumont, Ph.D. (circadian rhythms in humans); Gilles Lavigne, DMD., M.Sc. (motor behaviors in human sleep).

4. Types Of Training Available:

Graduate and Post-graduate; students are affiliated with the University of Montreal  departments of Psychology, Neuroscience or Biomedical Science (Psychiatry).

5. Types Of Funding Available:  Students can apply for provincial and federal bursaries.

6. Number and Names Of Current Trainees:

  Helene Marchand Intern in Biology
  Antonio Zadra   Post-doctoral student in Psychiatry, Universite de Montreal
  Anny Sauvageau Doctoral student in Neurological Sciences, Universite de Montreal
  Laure McCormick  Doctoral student in Neuropsychology, Universite de Montreal
  Michel Ouellette  Masters Student in Psychology, Universite de Montreal
  Anne Germain  Doctoral Student in Psychology, Universite de Montreall

7. Students Who Have Completed Training In The Past Five Years and Current Status : N/A

8. Primary Research Focus Of Laboratory:

       +  Psychophysiology of sleep
       +  Quantitative analysis of the EEG
       +  Laboratory and Home studies of nightmares
       +  Analysis of dreaming and dream content
       +  Dreaming and emotion

9. Technical Capabilities Of The Lab:

       *  32-channel electrophysiology
       *  Quantitative EEG;

10. Primary Training Focus: Experimental research in psychology and neuroscience; clinical

11. Other Training Opportunities:

The Dream & Nightmare Laboratory is part of the Sleep Disorders Center of the Sacred Heart Hospital, which is comprised
of specialists in chronobiology, all sleep disorders, bruxism and other rhythmic movement disorders of sleep (See #3). 

12. Representative Publications For Last Five Years:

Hassainia, F., Petit, D., Nielsen, T., Gauthier, S., & Montplaisir, J. (in press). Quantitative EEG amd statistical mapping of wakefulness and REM sleep in the evaluation of mild to moderate Alzheimer’s disease.  European Neurology, 176.

Lavigne, G.J., Lobbezoo, F., Rompre, P.H., Nielsen, T.A., & Montplaisir, J (in press).  Smoking as a risk factor for sleep bruxism and movement disorders, Sleep.

McCormick, L., Nielsen, T.A., Ptito, M., Ptito, A., Villemiure, J.-G., Vera, C., Montplaisir, J. (in press).  REM sleep dream mentation in right hemispherectomized patients.  Neuropsychologia.

Ouellet, L., Nielsen, T.A., Montplaisir, J., Cartier, A., Malo, J.L., & Lassonde, M. (1996).  L’alexithymie, reponse affective et
reves: Investigation en laboratoire de trois characteristiques sous-jacentes au deficit de l’expression des emotions.  Revue
Internationale dePsychopathologie, 23:491-503.

Sauvageau, A., Nielsen, T.A., & Montplaisir, J. (1966). Densite et amplitude des mouvements oculaires apres application d’une
stimulation somatosensorielle en sommeil paradoxal: Effets sur des dymnastes et des sujet controles.  Revue Internationale de
Psychopathologie, 23:479-489.

Nielsen, T.A., Ouellet, L., Warnes, H., Cartier, A., Malo, J.L., & Montplaisir, J. (1996). Alexithymia and impoverished dream
recall in asthma:  Evidence from self-report measures.  Journal of Psychosomatic Research, 41.

Nielsen, T.A., & Montplaisir, J. (1996).  Is interhemispheric coupling reduced after callosotomy?  A critique.  Perceptual and
Motor Skills, 83:348-350.

Powell, R.A., & Nielsen, T.A. (1996).  Temporal delays in incorporation of events into dreams:  A reply to Rolls.  Perceptual and
Motor Skills, 82:88-90.

Kuiken, D., & Nielsen, T.A. (1996).  Individual differences in orienting activity mediate feeling realization in dreams:  I. Evidence
from retrospective reports of movement inhibition.  Dreaming, 6:201-217.

Powell, R.A., Nielsen, T.A., Cheung, J.S., & Cervenka, T.M. (1995).  Temporal delays in incorporation of events into dreams.
Perceptual and Motor Skills, 81:95-104.

Nielsen, T.A., Dumont, M., Montplaisir, J. (1995).  A 20-hr. recovery sleep after prolonged sleep restriction: Some effects of
competing in a world record-setting cinemarathon.  Journal of Sleep Research, 4:78-85.

Montplaisir, J., Chicoine, A.-J., & Nielsen, T. (1995).  Nocturnal sleep and its relation to diurnal cognitive functioning.  Journal of
Sleep Research, 4:21-22.

Nielsen, T.A. (1995).  Describing and modeling hypnagogic imagery using a systematic self-observation procedure.  Dreaming,
5:75-94.

Montplaisir, J., Petit, D., Lorrain, D., Gauthier, S., & Nielsen, T. (1995). Sleep in Alzheimer’s Disease:  Further considerations on
the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms.  Sleep, 18:145-148.

Nielsen, T.A., & Montplaisir, J. (1994).  Commentary to Dreaming and REM sleep.  World Federation of Sleep Research
Societies Newsletter, 3:15-16.

Perlis, M.L. & Nielsen, T.A. (1993) Mood regulation and REM dreaming: A re-evaluation of the desensitization hypothesis.
Dreaming, 3:243-257.

Nielsen, T.A., Montplaisir, J. & Lassonde, M. (1993) Dreaming in agenesis of the corpus callosum: laboratory and home
assessment of four cases.  Journal of Sleep Research, 2:82-87.

Nielsen, T.A. (1993) Changes in the kinesthetic content of dreams following somatosensory stimulation of the leg muscles in
REM sleep.  Dreaming, 3:99-113.

Nielsen, T.A. & McGregor, D.L., Zadra, A., Ilnicki, D. & Ouellet, L. (1993) Pain in dreams. Sleep, 16:274-292.

Nielsen, T.A., Montplaisir, J. & Lassonde, M. (1993) Decreased interhemispheric EEG coherence during sleep and wakefulness
In agenesis of the corpus callosum.  European Neurology, 33:174-177.

Nielsen, T.A., Montplaisir, J. & Lassonde, M. (1992) Sleep architecture in agenesis of the corpus callosum: Assessment of four
cases.  Journal of Sleep Research   1:197-200.

Nielsen, T.A. (1992) A self-observational study of spontaneous hypnagogic imagery using the upright napping procedure.
Imagination, Cognition, and Personality, 11:353-366.

Nielsen, T.A. & Powell, R.A. (1992) The day-residue and dream-lag effects: A review and limited replication. Dreaming,
2:67-77.

1. Affiliation: 1996-1997 Entry -  Department of Psychology, University of Nijmegen, The Netherlands
 
2. Name & Address: Anton Coenen, Ph.D.

NICI, Department of Psychology,
University of Nijmegen, P.O. Box 9104
6500 HE Nijmegen, Netherlands

Phone: (31)-24-36-25-44;
FAX: (31)-24-36-16-66;
E-mail: hilgers@nici.kun.nl

3. Other Faculty:

Dr. Gilles van Luijtelaar, Ph.D. (physiological psychology), Dr. Pim Drinkenburg, Ph.D. (physiological psychology)

4. Type Of Training Available: All training levels are available.
 

5. Types Of Funding Available:

Occasionally, small funds are available for students of Universities having a central agreement with University of Nijmegen.

6. Number and Names Of Current Trainees: (2)

Agnieszka Unrug (University of Krakow, Poland), Jarek Bener (University of Krakow, Poland)

7. Students Who Have Completed Training In The Past Five Years and Their Current Status:
 

+ Neurophysiology of sleeping and waking
+ Psychoactive drugs (benzodiazepines) and cognition
+ REM sleep
+ Cognition and sleep

9. Technical Capabilities Of The Lab:

* EEG and EMG recording in free moving rats
* EEG recording of humans
* Neuropsychological testbatteries for humans
* Actigraphic monitoring
* REM sleep deprivation techniques
* VEP's and AEP's

10. Primary Training Focus: Training in Cognitive Neuroscience

11. Other Training Opportunities:

University of Krakow, Department of Psychophysiology, Poland (Prof. J. Kaiser); Polish Academy of Sciences, Institute of Pharmacology, Krakow, Poland (Prof. R. Przewlocki) Graduate course in 'Principles of Neuroscience'

12. Representative Publications For Last Five Years:

Coenen, A.M.L. Ates, N., Skarsfeldt, T. and Van Luijtelaar, E.L.J.M., Effects of sertindole on sleep-wake states, electroencephalogram, behavioural patterns and epileptic activity of rats, Pharmacology Biochemistry and Behaviour, 51, 353-357, 1995

Van Luijtelaar, E.L.J.M. and Coenen, A.M.L., Effects of remacemide and FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy, Neuropharmacology, 34, 419-425, 1995

Gorissen, M., Eling, P., Van Luijtelaar, E. and Coenen, A., Effects of diazepam on encoding processes, Journal of Psychopharmacology, 9, 113-121, 1995

Coenen, A.M.L., Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing, Neuroscience and Biobehavioral Reviews, 19, 447-463, 1995

Van Luijtelaar, E. and Coenen, A., The behavioural pharmacology of sleep, in: Methods in behavioral pharmacology, F. van Haaren (ed.), Elsevier Science Publishers, 575-602, 1993

Coenen, A.M.L., Drinkenburg, W.H.I.M., Inoue, M. and Van Luijtelaar, E.L.J.M., Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats, Epilepsy Research, 12, 75-86, 1992

1. Affiliation: 1995-1996 Entry - University of Ottawa, Canada - Department of Medicine

2. Name Roger Broughton, M.D., Ph.D.

3. Faculty: Qais Ghanem, M.D., Jonathan Wilmer, M.D., Robert Dales, M.D.

4. Type of training available:

* Research fellowship in sleep and biological rhythms research
* Ph.D. postgraduate research programs (School of Psychology, University of Ottawa)
* Clinical sleep disorders training at the Ottawa General Sleep Disorders Clinic

5. Types of funding available: Candidate must currently supply own funding.

6. Number and names of current trainees: 1 post-doctoral fellow, 3 doctoral graduate students:

Post-Doctoral Fellows: Dorothy Bruck, Ph.D.
Graduate Students: Claude Manseau, M.A., Suzanne Krupa, M.S.C., Wayne Dunhamm, M.Sc.

7. Students who have completed training in the past five years and current status:

Janice Newman, Ph.D. Clinical Researcher Canadian Association of Nurses
Janet Mullington, Ph.D. Post-Doc Fellow Max Planck Institute, Munich, Germany

8. Laboratory facilities:
 

9. Technical capabilities of the lab:

+ Two bedroom sleep research laboratory
+ Extensive computer capabilities for spectral analysis, EEG topographical mapping
+ Event related potentials
+ Ambulatory sleep/wake monitoring
+ Wrist actigraphy, reaction time and performance testing

10. Primary training focus: Graduate training in experimental and clinical psychology.

11. Other training opportunities: No information provided

12. Research areas and sample publications:

Broughton, R., Billings, R., Cartwright, R., Doucette, D.,Edmeads, J., Edwardh, M., Ervie, F., Orchard, B., Turrall, G. and Hill, W. (1994) Homocidal somnambulism: a case report. Sleep, 17:253­264.

Mullington, J. and Broughton, R. (1993) Scheduled naps in the management of daytime sleepiness in narcolepsy­cataplexy. Sleep, 16:444­456.

Mullington, J. and Broughton, R. (1994) Daytime sleep inertia in narcolepsy-cataplexy. Sleep, 17:69-76.

Broughton, R., Dunham, W., Weisskopf, M., Rivers, M. (1994) Night sleep does not predict day sleep in narcolepsy. Electroenceph. Clin. Neurophysiol., 91:67-70.

Broughton, R. and Mullington, J. (1994) Circadian, semi-circadian and ultradian aspects of narcolepsy. Sleep, 17:S35-S44.

Broughton, R., Parasomnias. In: S. Chokroverty (ed.), Sleep Disorders Medicine. Butterworth/Heinnemann, Stoneham, MA, 1993:381-399.

Broughton, R. (1994) L'investigation de la vigilance et de la somnolence dans les desordres du sommeil. Dans: M. Billard (ed.), Le Sommeil et Ses Troubles. Masson, Paris, pp. 125-141.

Dinges, D. and Broughton, R. (Eds). (1989) Sleep and Alertness: Chronobiological, Behavioral and Medical Aspects of Napping. Raven, New York, pp. 322.

Broughton, R. and Ogilvie, R. (Eds). Sleep, Arousal and Performance. Birkhauser, Boston, 1991, pp. 1-273.

1. Affiliation: 1997-1998 Entry - School of Psychology, University of Ottawa, Canada

2. Name & Address: Joseph DeKoninck, Ph.D.

School of Psychology, University of Ottawa
P.O. BOX 450 STN A
OTTAWA, ONTARIO K1N 6N5 CANADA

Phone: (613) 562-5800 ext. 1234;
FAX: (613) -562-5730;
E-Mail: JDEKONIN@UOTTAWA.CA

3. Other Faculty: Kenneth Campbell, Ph.D., R. Terry Pivik, Ph.D.

4. Type Of Training Available:

Ph.D. in Clinical Psychology (CPA and APA accredited), Ph.D. in Experimental Psychology
 
Admission on the basis of Honours degree or of Masters degree.

Admission is very competitive and priority is given to bilingual (English and French) applicants. Both doctoral programs can be completed with a Neuroscience Specialization involving several departments. Students complete their doctoral thesis in one area of sleep and dream research, and if desired their comprehensive examination. Part of clinical internship can include sleep disorders (Broughton). One undergraduate course on Sleep and Dreams. Two graduate seminars. Mostly informal seminars involving researchers and students from the Ottawa area and visitors.

5. Types Of Funding Available:

Internal funding comprises Graduate School scholarships,  TAs, RAs, and supervisors research funds (MRC, NSERC).

6. Number and Names Of Current Trainees:

7  doctoral students are currently completing their thesis in the sleep and dreams areas.

7. Students Who Have Completed Training In The Past Five Years and Current Status:

7 PhD graduates over the last 5 years.

Roger Broughton:
 Janice Newman: No information
 Janet Mullington:   Research Associate, Experimental Psychiatry, University of Pennsylvania
 Claude Manseau:   Centre de readaptation "La Ressource", Hull

Ken Campbell:
 Derek Loewy:    Post-doctoral Fellow, University of Arizona
 Ian Bell:    Private computer/biomedical consultant
 Diana Deacon:    Associate Professor, City College of New York, USA
 Braxton Suffield:   Associate Professor, University of Western Ontario
 Celyne Bastien:   Research Associate, Universite Laval

Joseph De Koninck:
 Dominique Lorrain:   Assistant Professor, Universite de Sherbrooke
 Marcel Viens:    Private Practice
 Gregory Christ:   Post doc, McGill University
 Gilles Hebert:    Private Practice

R. Terry Pivik:
 Lise Mercier:    Private Practice
 Serge Lessard:   Medical School

8. Primary Research Focus Of Laboratory:

See publications

9. Technical Capabilities Of The Lab:

Each of the four professors has his own laboratory with typically at least two bedrooms and various recording equipment, for a total of eight beds.  R. Broughton has also a hospital based sleep clinic.

10. Primary Training Focus: Full spectrum of clinical training

11. Other Training Opportunities: No information provided.

12. Representative Publications For The Last Five Years:

Roger Broughton, M.D.(Queen's),Ph.D.(McGill),FRCPC,Professor.  Sleep & its disorders.  Biological Rhythms and Chronobiology. Vigilance

Krupa, S., Houlihan, M., Dunham, W., Rivers, M., Mullington, J. and Broughton, R. (In Press)  Daytime impairment of arousal in narcolepsy:  an update.  Sleep Res., 26.

Broughton, R., Fleming, J., George, C., Hill, J., Kryger, M., Moldofsky, H. Montplaisir, J., Morehouse, R., Moscovitch, A. and
Murphy, W. (1996)  Narcoleptics on and off methylphenidate; a comparison of sleep, MWT and performance measures.  Sleep Res.,25:216.

Broughton, R.J. and Hasan, J. (1995)  Topographic EEG mapping during drowsiness and sleep onset.  J. Clin. Neurophysiol., 2:372-386.

Broughton, R. and Shimizu, T. (1995)  Sleep-related violence: a medical and forensic challenge.  Sleep, 18:727-730.

Zwicker, J., Bruck, D., Parkes, J.D. and Broughton, R.J. (1995)  Acute mood improvement after amphetamine and methylphenidate in narcolepsy.  J. Sleep Res., 4:252-255.

Kenneth Campbell, B.A. (N.B.), M.A., Ph.D., Professor. Human neurophysiological measures of information processing, cognitive activity during loss of consciousness, sleep.

DeLugt, D.R., Loewy, D.H. and Campbell, K.B. (1996)  The Effect of Sleep Onset on Event-Related Potentials with Rapid Rates of Stimulus Presentation.  EEG and Clinical Neurophysiology, 98, 489-492.

Loewy, D.H., Campbell, K.B. and Bastien, C. (1996)  The Mismatch Negativity to Frequency deviant Stimuli during Natural Sleep.  EEG and Clinical Neurophysiology, 98, 493-501.

Bastien, C., & Campbell, K.B. (1992)  The evoked K-complex:  All-or-none phenomenon.  Sleep, 236-245.

Joseph-M. De Koninck, B.A.(Laval), B.A.(Ps.) (ibid), M.A.(Ps.)  (ibid), Ph.D. (Man.), Professor.  Psychophysiology of sleep, dreaming, sleep and learning, slow wave sleep mechanisms, insomnia, biological rhythms and sleep.

De Koninck, J., Prevost, F. & Lortie-Lussier, M. (1996). The effects of inversion of the visual field on REM sleep mentation. Journal of Sleep Research,5, 16-20.

Christ, G., De Koninck, J., Hebert, M., Carrier, J., Lamarche, C. & Dufour, S.  (1996) Body temperature and the return of slow wave activity in extended sleep.  Electroencephalography and Clinical Neurophysiology, 98, 42-50.

Roussy, F., Camirand, C., Foulkes, D., De Koninck, J. Loftis, M. & Kerr, N.H. (1996)  Does Early-night REM Dream Content Reliably Reflect Presleep State of Mind?  Dreaming, 6, 2.

Hebert, G., De Koninck, J. (1994) Frontal and parieto-temporal EEG in REM sleep during second language training. Journal of Sleep Research, 3, 1, 100.

R. Terry Pivik, B.A., M.A. (Wyo.), Ph.D. (Stan.), Professor. Neurophysiologic and psychophysiologic correlates of sleep and psychiatric disturbances.

Pivik, R.T., Busby, K. (1996)  Heart rate associated with sleep onset in preadolescents.  Journal of Sleep Research, 5:33-46.

Pivik, R.T., Busby, K.A., Gill, E. Hunter, P., Nevins, R. (1996)  Heart Rate Variations During Sleep in Preadolescents.  Sleep, 19(2):117-135.

Pivik, R.T., Harman, K. (1995)  A reconceptualization of EEG alpha activity as an index of arousal during sleep: all alpha activity is not equal.  J. Sleep Res. 4:131-13.

Busby, K.A., Mercier, L., Pivik, R.T. (1994)  Ontogenetic variations in auditory arousal threshold during sleep.  Psychophysiology, 31:182-188.

Pivik, R.T., Broughton, R.J., Coppola, R., Davidson, R.J., Fox, N. & Nuwer, M.R. (1993)  Guidelines for the recording of quantitative analysis of electroencephalographic activity in research contexts, Psychophysiology, 30:547-588.

Mercier, L., Pivik, R.T., Busby, K. (1993)  Sleep patterns in reading disabled children.  Sleep 16(3):207-215.

INFORMATION: Request for application forms and information for admission to the Ph.D. program should be addressed to:
 
   School of Psychology Graduate Office
   145 Jean-Jacques Lussier
   PO BOX 450 STN A,
   OTTAWA ON   K1N 6N5 


   Telephone: (613)-562-5801
   Fax: (613)-562-5147

1. Affiliation: 1996-1997 Entry -  Shanghai Institute of Physiology, Academia Sinca - Research Unit of Sleep and Wakefulness

2. Name & Address: Shiyi Liu, Ph.D.

Shanghai Institute of Physiology Academia Sinica
320 Yue Yang Road
Shanghai 200031, CHINA

FAX: 86-21-6433-2445;
E-Mail: syliu@chdm.shlc.ac.cn

3. Other Faculty:
4.  Type Of Training Available: The Institute offers a M.Sc. or Ph.D. program in sleep research. Research dissertation for graduating class students from Universities or Colleges; Master or Ph.D. degree students.

5. Types Of Funding Available:

Students from abroad should be supported by themselves, though we will offer some limited benefits.

6. Number and Name Of Current Trainees: (2) Fan Rong; Chen Wenyan.

7. Students Who Have Completed Training In The Past Five Years and Current Status:

LiH,Y.., M.Sc. Ph.D. Student, USA
JiR.R., Ph.D. Postdoctoral Fellow, USA
SuJ.D., Ph.D. Research Associate,

8. Primary Research Focus Of Laboratory:

+ Mechanism of sleep and wakefulness
+ Circadian and circasemidian rhythms
+ Sleep- and wakefulness-inducing substances

9. Technical Capabilities Of The Lab:

* One in vivo and one in vitro labs for animal studies and one bedroom lab for human studies
* Equipped with EEG, Axoprobe instruments, data recorder, computer capabilities, minilogger, etc.
* Labs for histochemistry and chemical isolation

10. Primary Training Focus: Circadian rhythm and neuropeptides

11. Other Training Opportunities:

12. Representative Publications For Last Five Years:

Liu SY, Chen Ming, Zhang Yi, et al. A study on circadian body termperature "clock" in young adult subjects. Acta psycholoica sinica 1993, 4, 264-270.

Liu SY, Humoral control of sleep and wakefulness related to moleculat structural conformation. In Kumar VM, Malik NH U (eds) Sleep-Wakefulness, Wiley Eastern, New Delhi, 1993, pp. 8-10.

Liu S. Y, Zhang Y, Xu JC et al. Pyrogenic effect and muramyl peptides, In Du Y.C., Tam J.P. (eds) "Peptides - Biology and Chemistry", ESCOM, Leiden, 1993, pp. 81-82.

Liu SY, Zhang WY, Xu JC, et al. Studies on the isolation of endogenous sleep factors from Tupaia belangeri chinensis (TBS) after sleep deprivation. Acta Physiol. Sinica 46:, 83-89; 1995.

Su JD and Liu SY The efferent connections of the hypothalamic Suprachiasmatic N in tupaia belangeri chinensis. Chin J Neuroanatomy 11:359-362; 1995.

Liu SY Chinese philosophical and medical views on chronobiology and sleep. In: Liu, S.Y. and Inoue S. (Eds) "Sleep: Ancient and Modern" SSTLPH, Shanghai, 1995. pp. 1-24.

1. Affiliation: 1996-1997 Entry - Sleep Laboratory and Sleep Medicine Center Technion­Israel Institute of Technology

2. Name & Address: Peretz Lavie

Technion-Israel Institute
Gutwirth Building
Technion City, Haifa Israel 32000

Phone: 972-4-226695;
FAX: 972-4-323045;
E-Mail: plavie@techunix.technion.ac.ii

3. Other Faculty:

Ron Peled (MD, neurology, Diplomate American board of sleep medicine), Naama Yaffe (MD, ENT), Yulia Berger (MD general medicine), A­H Rubin (MD, pulmonary medicine), K Sheffi (biomedical engineering), R. Path­Horenchik (PhD clinical psychology): Clinical and research associates in volved in research and clinical activities of the sleep medicine center.

4. Type Of Training Available: We are involved in training in all levels:

* Undergraduate/graduate: Teaching the following courses: psychology to medical students, introduction to sleep research (med students and graduate students), sleep disturbances (fourth year medical students), psychophysiology of states of conciousness (advanced seminar to graduate students).
* DSc/MSc program: We accept graduate students for the MSc/DSc programs based on previous achievements and availability of resources. The degrees are equivalent to MA/PhD in other universities.
* Post­doc positions and fellowships: Available on a competitive basis. We also have openings for residents and basic science training courses (6 months periods) which are required from Israeli physicians, as well as for electives (2­weeks to 1 month periods). Recently we agree to accept pulmonary physicians for 2­week rotations in the lab.

5. Type Of Funding:

Graduate students can apply for financial support. Decisions are made on a competitive basis and usually the support is available only during the second semester. Post­Doc positions are available on a competitive bases. Registration must be completed a year in advance.

6. Number and Names Of Current Trainees:

Graduate students: A Gonen, I Haimov, I Berlad, T Shochat
MD thesis students: N Peled, T Nave, A Einraich, A Weisner.

7. Students Who Have Completed Training In The Past Five Years:

There is a large number of students who graduated in the last 5 years. The following is just a partial list:
 

8. Primary Research Focus Of Lab:

+ The effects of melatonin on sleep
+ Sleep propensity
+ Inheritance of sleep apnea
+ Sleep of school children
+ Improving shiftwork
+ Sleep and dreaming in traumatized patients
+ Actigraphs for ambulatory monitoring.

9. Technical Capabilities Of Lab:

The Technion sleep lab is equipped to conduct large scales sleep studies. Six beds available for polysomnographic recordings. Computer facilities also available for spectral analysis of EEG. The Technion Sleep Medicine Center has also three additional laboratories in Tel Aviv and Jerusalem with 14 additional beds which can be used in clinical studies.

10. Primary Training: MSc/DSc programs

11. Other Training Opportunities: Any other Technion Faculty with a graduate program

12. Representative Publications For Last Five Years:

Haimov I et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 309:167, 1994.

Tzischinsky O & Lavie P. Melatonin possesses a delayed hypnotic effect which is time­dependent. Sleep 17, 638­645, 1994.

Nave R, Herer P, Lavie P. The intrinsic effects of Sarmazenil on sleep propensity and performance of sleep­deprived subjects. Psychopharmacology 155: 366­370, 1994.

Pillar G, and Lavie P. Assessment of the role of inheritance in sleep apnea syndrome. American Review of Respiratory Disease (in press).

Lavie et al. Mortality in sleep apnea patients: A multivariate analysis of risk factors, (in press).

1. Affiliation: 1997-1998 Entry - Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

2. Name & Address: Shojiro Inoué, D.Sc.

Institute for Medical and Dental Engineering
Tokyo Medical and Dental University
Kanda-Surugadai 2-3-10, Chiyoda-ku
Tokyo 101, Japan

Phone: (81) 3-5280-8095
Fax: (81) 3-5280-8099

3. Other Faculty: Michio Toru, M.D. (Psychiatry) is involved in the Department of Neuropsychiatry, School of Medicine, Tokyo Medical and Dental University

4. Type Of Training Available:

Graduate course: Sleep science
Special research course: Sleep science
Postdoctoral opportunities: Available if funded.

5. Types Of Funding Available:

* Monbusho scholarship for graduate students
* JSPS fellowship for postdoctoral fellows

6. Number and Names Of Current Trainees: (6)

Graduate students:  Tsuyoshi Hasegawa, Shi-Qing Zhang, Shinji Azuma
Special research students: Shin Fujiwara, Zili Luo, Tetsu Watanuki

7. Students Who Have Completed In The Past Five Years and Their Current Status:

Masayuki Ikeda, Ph.D. Assistant Professor at Waseda University

8. Primary Research Focus Of Laboratory:

 * Studies on the physiological roles of sleep substances in the regulation of sleep
 * Dynamic analysis of sleep-modulatory substances and neuronal activities in the brain
 * Time series analysis of sleep in relation to the circadian and reproductive rhythms
 * Correlation of endocrine activities with sleep and wakefulness
 * Spatio-temporal analysis of electrical activities in the sleeping brain

9. Technical Capabilities Of The Lab:

* Five isolated chambers with simultaneous recordings of EEG, EMG, brain temperature, and continuous
   intracerebroventricular infusion
 * One isolated chamber for human sleep study
 * One isolated chamber for in vitro electrophysiological study

10. Primary Training Focus: Graduate training in sleep science.

11. Other Training Opportunities:

Department of Neuropsychiatry, School of Medicine, Tokyo Medical and Dental University (Michio Toru, M.D.).

12. Representative Publications For Last Five Years:

Inoue, S. (1993). Sleep-Promoting Substance (SPS) and physiological sleep regulation. Zoological Sciences, 10, 557-576.

Kimura-Takeuchi, M. & Inoue, S. (1993). Differential sleep modulation by sequentally administered muramyl dipeptide and uridine. Brain Research Bulletin 31, 33-37.

Kimura-Takeuchi, M. & Inoue, S. (1993). Lateral preoptc lesions void slow-wave sleep enhanced by uridine but not by uramyl dipeptide in rats. Neuroscience Letters 157, 17-20.

Honda, K., Komoda, Y. & Inoue, S. (1994). Oxidized glutathione regulates phy siological sleep in unrestrained rats. Brain Research 636, 253-258.

Inoue, S, Honda, K. & Komoda, Y. (1995). Sleep as neuronal detoxiflcation and restitution. Behavioral Brain Research 69, 91-96.

Zhang, S.-Q., Kimura, M. & Inoue, S. (1995). Sleep patterns in cyclic and pseudopregnant rats. Neuroscience Letters 193, 125-128.

lkeda M., Honda, K. & Inoue, S. (1995). Circadian time-dependent modulation of sleep and brain temperature (Tbr) by methylcobalamin and resultant prolongation of Tbr freerunning period in rats. Biological Rhythm Research 26, 521-531 .

Inoue, S: Challenges to the ancient concept of humoral sleep regulation. In:  Sleep - Ancient and Modern, ed. Liu SY,  Inoue, S, Shanghai Scientific and Technological Literature Publishing House, Shanghai/ Asian Sleep Research Society, Tokyo, 55-88, 1995.

Inoue, S. Pharmacology of the CNS peptides. In: Handbook of Pharmacology 11 6: Pharmacology of Sleep, ed. Kales A,
Springer-Verlag, New York, 243-277, 1995.

Ikeda M, Honda K, Inoue, S: Vitamin B12 amplifies light pulse-induced phase shifts of the circadian drinking rhythm in rats. Experientia 52: 691-694 , 1996.

Azuma S, Kodama T, Honda K, Inoue, S: State-dependent changes of extracellular glutamate in the medial preoptic area in freely behaving rats. Neuroscience Letters 214: 179-182, 1996.

Kimura M, Zhang S-Q, Inoue, S: Pregnancy-associated sleep changes in the rat. American Journal of Physiology 271: R1063-R1069, 1996.

Zhang S-Q, Kimura M, Inoue, S: Bromocriptine-induced blockade of pregnancy a ffects sleep patterns in rats. Neuroimmunomodulation 3: 219-226, 1996.

1. Affiliation: 1997-1998 Entry - Center for Sleep and Chronobiology, Institute of Medical Science University of Toronto, Canada

2. Name & Address: Harvey Moldofsky, M.D.

University of Toronto Center for Sleep and Chronobiology
The Toronto Hospital - Western Division
399 Bathurst Street  MP 14-308
Toronto, Ontario  M5T 2S8  CANADA 


Phone:  (416)-603-5109;
FAX: (416)-603-2388,
E-Mail: h.moldofsky@utoronto.ca
 

3. Other Faculty:

Georg Bjarnasson, M.D. (Dept. of Medicine), Douglas Bradley, M.D., (Dept. of Medicine), Gregory Brown, M.D., Ph.D. (Dept.of Psychiatry), Roger Goldstein, M.D.  (Dept. of Medicine), Reginald M. Goprczynski, Ph.D., M.D. (Depts. of Surgery and Immunology), Patrick Hanly, M.D. (Dept. of Medicine), Michael Hawke, M.D., (Dept, of Otolaryngology), Jack Hay, Ph.D. (Dept. of Immunology); Ronald Heslegrave, Ph.D. (Depts. of Psychiatry/Community Health), Victor Hoffstein (Dept. of Medicine), Franlin A. Lue, M.Sc. (Dept. of Psychiatry), James G. MacFarlane, Ph.D. (Dept. of Psychiatry), Alistair MacLean, Ph.D. (Dept. of Psychology - Queens University), Ian MacLusky, M.D. (Depts. of  Pediatrics/Medicine), Paul Morris, M.D. (Dept. of Psychiatry), Elliot Phillipson, M.D. (Dept. of Medicine), Manny Radomski, Ph.D. (Exercise Physiology/DCIEM), Martin Ralph, Ph.D. (Dept. of Psychology), W. John Reynolds, M.D. (Dept. of Medicine), Sheldon Shaul, M.D. (Dept. of Psychiatry), Otto Veidlinger, M.D. (Dept. of Medicine).

4. Types of Training Available:

 *  Graduate Training:  M.Sc. and Ph.D.
 *  Postdoctoral opportunities
 *  Clinical Training for Polysomnographic Technicians and Registered Polysomnographic Technologists
 *  Clinical Fellowships
 *  Psychiatric/Medical Resident Training in Sleep Medicine

5. Types Of Funding Available (Trainee Support): Toronto Psychiatric Research Foundation

6.  Types of Funding Available (Laboratory Grants):

 *  Canadian Space Agency/NASA
 *  The Linbury Trust (U.K.)
 *  American Fibromyalgia Syndrome Association (U.S.)
 *  Institute for Work and Health of Ontario
 *  Medical Research Council (Canada)
 *  Department of Natrional Defence (Canada)
 *  Contracts:  Various Pharmaceutical and Industrial Companies)

7. Number and Names Of Current Trainees:
 

Adam Blackman     M.Sc. Student
Angela Cesta      M.Sc  Student
Borys Chabursky  M.Sc. Student
Penny Corkrum  Ph.D. Student
Jodi Dickstein    Ph.D. Student
Paul Draga   M.Sc. Student
Deborah Sutton M.Sc. Student
Karl Thaiss   M.Sc. Student
 

9. Students who have completed training in the last 5 years and current status:

+  Immune and neuroendocrine functions in sleep
+  Fibromyalgia/Chronic Fatigue Syndrome
+  Circadian Rhythms and Chronobiology
+  Respiratory Sleep Medicine
+  Periodic Phenomenon in Sleep
+  Parasomnia Disorders
+  Insomnias
+  Narcolepsy and related disorders

10. Technical capabilites of lab:

*  Sleep Disorders Clinic (Grass polygraphs, Sandman computerized polysomnography)
*  Ambulatory Monitoring Systems:  actigraphy, EEG sleep physiology (Medilog)
*  Behavioural Immunology Laboratory)

11. Primary Training Focus:

* Graduate Training at the Masters and Ph.D. level
* Clinical training in Sleep Medicine

12. Other Training Opportunities: Clinical training for polysomnographic technicians and registered polysomnographic technologists

13. Representative Publications For Last Five Years:

MacFarlane JG, List SJ, Moldofsky H, Firnau G, Chen JJ, Szechtman H, Garnett S, Nahmiats C.  Dopamine D2 receptors quantified in vivo in human narcolepsy.  Biol Psychiatry 41:305-310, 1997.

MacFarlane JG, Shalal B, Moldofsky H. Periodic K-alpha sleep EEG activity and periodic leg movements during sleep: Comparisons of clinical features and sleep parameters.  Sleep 19(3):200-204, 1996.

Pearl SJ, Lue F, MacLean AW, Heslegrave RJ, Reynolds WJ, Moldofsky H.  The effects of bright light treatment on the symptoms of fibromyalgia.  J Rheumatol 23(5):896-902, 1996.

Moldofsky H, Lue FA, Mously C, Roth-Schechter B, Reynolds WJ.  The effect of zolpidem in patients with fibromyalgia:  A dose ranging, double blind, placebo controlled, modified crossover study.  J Rheumatol 23(3):529-533, 1996.

Moldofsky H, Gilbert R, Lue FA, MacLean AW.  Sleep-related violence.  Sleep 18(9):731-739, 1995.

Moldofsky H.  Fibromyalgia and chronic fatigue syndrome:  Clinical and sleep physiologic similarities.  EOS J Immunol. Immunopharmacol 15(1-2):45-49, 1995.

Moldofsky H, Lue FA, Shahal B, Jiany CG, Gorczynski RM.  Diurnal sleep/wake-related immune functions during the menstrual cycle of healthy young women.  J Sleep Res 4:150-159, 1995.

MacLean AW, Lue FA, Moldofsky H.  The reliability of visual scoring of alpha EEG sleep.  Sleep 18(7):565-569, 1995.

Moldofsky H. Sleep and the Immune System.  Int. J. Immunopharmac, 17(8):649-654, 1995.

Crook J, Moldofsky H.  Prognostic indicators of disability after a work-related musculoskeletal injury.  J Musculoskeletal Pain 3(2):155-159, 1995.

Moldofsky H.  Sleep,wakefulness, neuroendocrine and immune functions in fibromyalgia and chronic fatigue syndrome. J Musculoskeletal Pain 3(2):75-79, 1995.

Fleming J, Moldofsky H, Walsh JK, Scharf M, Nino-Murcia G, Radonjic D.  Comparison of the residual effects and efficacy of short-term zolpidem, flurazepam, and placebo in patients with chronic insomnia.  Clin Drug Invest 96(6):303-313, 1995.

Wolfe F, Aarflot T, Bruusgaard D, Henriksson KG, Littlejohn G, Moldofsky H, Raspe H, Vaeroy H.  Fibromyalgia and Disability Report of the Moss International Working Group on Medico-Legal Aspects of Chronic Widespread Musculoskeletal Pain Complaints and Fibromyalgia.  Scan J Rheumatol 24:112-118, 1995.

Moldofsky H. Sleep, Neuroimmune and Neuroendocrine functions in Fibromyalgia and Chronic Fatigue Syndrome.  Adv. in Neuroimmunol.  5:39-56. 1995

Crook J, Moldofsky H.  The probability of recovery and return to work from work disability as a function of time.  Qual Life Res 3(1):S97-S109, 1994.

Moldofsky H.  Chronobiological influences on fibromyalgia syndrome:  Theoretical and therapeutic implications.  Bailliere’s Clin Rheumatol 8(4):801-810, 1994.

Moldofsky H.  Central nervous system and peripheral immune functions and the sleep-wake system.  J Psychiatry and Nerurosci 19(5):1-7, 1993.

Moldofsky H, Wong MTH, Lue FA.  Litigation, sleep, symptoms and disability in post accident pain (fibromyalgia).  J Rheumatol 20(11):1935-1940, 1993.

Moldofsky H.  A chronobiologic theory of fibromyalgia.  J Musculoskeletal Pain 1(3/4):49-59, 1993.

Maler T, Ralph MR, Gorczynski RM, Moldofsky H, O’Dowd BF, Chin Du D.  The drosophiolia per gene homologs are expressed in mammalian suprachiasmatic nucleus and heart as well as in molluscan eyes.  Biocherm Biophys Res Commun 184(2):1082-1087, 1992.

1. Affiliation: 1997-1998 Entry - Institute of Pharmacology, University of Zurich, Switzerland

2. Name & Address: Alexander A. Borbely M.D.

Institute of Pharmacology - University of Zurich
Winterthurerstr. 190
CH-8057 Zurich SWITZERLAND

Phone: +41-01- 257- 59 11;
FAX: +44-01-257-57-07;
E-Mail: borbely@pharma.unizh.ch

3. Other Faculty: Irene M. Tobler Ph.D., Zoology Peter Achermann Ph.D., Engineering and Signal Analysis

4. Type Of Training Available:

* Undergraduate/Graduate research assistantships
* Ph.D. Programs are available; and there are occasional
* Postdoctoral research opportunities available

5. Types Of Funding Available: Opportunities for funding will be discussed upon request

6. Number and Names Of Current Trainees: (11)

Undergraduate Students:
Michael Aeppli, Medicine Reto Hirt, Electrical Engineering
Reto Huber, Zoology Hanspeter Kunz, Computer Science
Pierre Magnin, Dentistry Axel van Beersum, Psychology

Graduate Students:
Tom Deboer, Biology Babara Schwierin, Biology
Corinne Roth, Pharmacy Esther Werth, Biology

Postdoctoral Scientist:
Takuro Endo, M.D., Ph.D.

7. Students Who Have Completed Training In The Past Five Years and Current Status:

     Daniel Aeschbach, Ph.D.  Postdoctoral Research Fellow, NIMH, Bethesda, MD
     Hanspeter Landolt, Ph.D. No information provided
     Herbert Kattler M.D.   Clinical Research Fellow, Departmentof Psychiatry, University Hospital, Zuerich
     Daniel Brunner Ph.D.  Postdoctoral Research Fellow, Dept.of Psychiatry, University of Pittsburgh
     Christian Cajochen, Ph.D.  Postdoctoral Research Fellow, Dept. of Psychiatry, University of Basel
     Paul Franken Ph.D.   Postdoctoral Research Fellow, Department of Biological Sciences, Stanford University
     Bo Gao MD   Postdoctoral Research Fellow, Center for Neuroscience, Pittsburgh
     Peter Joos, MD   Children's Hospital, University of Zuerich
     Neuner Jehle, PhD;   Postdoctoral Research Fellow, Laboratory of Cellular & Molecular Neurology, Gif sur Ivette
     Andrea Haner, M.D  No information provided

8. Primary Research Focus Of Laboratory:

     +  Homeostatic and circadian regulation of sleep in humans, other mammals and non-mammalian species
     +  Development of mathematical models of sleep
     +  Development and application of new methods of quantitative topographical EEG analysis.
     +  Natural hypometabolic states (daily torpor), sleep and photoperiodism in the Djungarian hamster.
     +  Genetic background of circadian parameters and sleep in knockout and transgenic mice
     +  Pharmacological aspects of sleep regulation.
     +  Role of potential endogenous sleep substances e.g., melatonin & adenosine receptor agonists
         and antagonists in sleep regulation.

9. Technical Capabilities Of The Laboratory:

      *  Four bedroom temporal isolation unit with kitchen and bathrooms
      *  Long term digital, polygraphic recording facility, 24 channels (EEG, EMG, EOG, ECG, body and skin temperature, illuminance, breathing parameters, etc.)
     *  15 486 PCs devoted to data analysis
     *  14 isolated chambers for sleep recordings in animals 40 cages equipped with running wheels connected to PCs for longterm recording of activity
     *  25 and 15 cages equipped with infra-red sensors
     *  Climatic chamber (13-23 C) equipped with 4 animal sleep recording chambers

10. Primary Training Focus: Graduate training in sleep research and biological rhythms

11. Other Training Opportunities: Graduate training in neuroscience in other University Institutes

12. Representative Publications For Last Five Years:

Achermann,P., Dijk,D.J., Brunner,D.P., Borbely,A.A. A model of human sleep homeostasis based on EEG slow  wave activity:
quantitative comparison of data and simulations. B Brain Res. Bull. 31 (1993) 97 113.

Achermann,P., Hartmann,R., Gunzinger,A., Guggenbuhl,W.,Borbely,A.A. Correlation dimension of the human sleep
electroencephalogram: Cyclic changes in the course of the night. Europ.J.Neurosc. 6 (1994) 497

Kattler,H., Dijk,D.J., Borbely,A.A. Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans.
J.Sleep Res. 3 (1994) 159 164.

Brunner,D.P., Munch,M., Biedermann,K., Huch,R., Huch,A., Borbely,A.A. Sleep and sleep EEG during pregnancy. Sleep, 17
(1994) 576 582.

Deboer,T. Tobler,I. Sleep EEG after daily torpor in the Djungarian hamster: similarity to he effects of sleep deprivation. Neurosci.
Lett. 166 (1994) 35 38.

Deboer,T., Tobler,I. Temperature dependence of EEG frequencies during natural hypothermia. Brain Res. 670 (1995)
153-156.

Franken,P., Tobler,I., Borbély,A.A.  Varying the photoperiod in the rat: profound effect on the 24-h sleep pattern but no effect on
sleep homeostasis. Am.J.Physiol. 269 (1995) R691-R701.

Gao,B., Franken,P., Tobler,I., Borbely,A.A. Effect of elevated temperature on sleep, EEG spectra, hypothalamic temperature and
cortical temperature in the rat. Am.J.Physiol. 268 (1995) R1365-R1373.

Werth,E., Borbély,A.A. Recording the sleep EEG with periorbital skin electrodes. Electroenceph.Clin.Neurophysiol. 94 (1995)
 406-413.

Landolt,H.P., Dijk,D.J., Gaus,S.E., Borbely,A.A. Caffeine reduces low-frequency delta activity in the human sleep EEG.
Neuropsychopharmacology 12 (1995) 229-238.

Aeschbach D., Cajochen,C., Landolt H.P., Borbely,A.A. Sleep regulation in habitual short sleepers and long sleepers.
Am.J.Physiol. 270 (1996) R41-R53.