_ = This type of training does NOT exist in the program

? = It is not known whether this type of training exists in the program 

1. Affiliation: 1997-1998 Entry -  Department of Psychology, University of Arizona Insomnia Clinic of the University of Arizona Sleep Disorders Center

2. Name & Address: Richard R. Bootzin, Ph.D.

Department of Psychology
University of Arizona
Tucson, AZ 85721

Phone: (602) 621-7447;
Lab: (602 621-5127;
FAX: (602) 621-9306
E-Mail: bootzin@ccit.arizona.edu

3. Other Faculty:

Rachel Manber, Ph.D. (Psychiatry), Stuart Quan, M.D. (Internal Medicine), Russell Dodge, M.D. (Internal Medicine), and Colin
Bamford, M.D. (Neurology) are research and clinical collaborators involved in the Sleep Disorders Center of the University of
Arizona Health Sciences Center.

4. Type Of Training Available: We are involved in training at all levels:

*Undergraduate/graduate: Psychology 478/578 Sleep and Sleep Disorders Research assistantships
*Graduate training: Typically, graduate students who work with me have been part of the clinical psychology graduate program.
*Clinical Psychology internships: The Insomnia Clinic of the Arizona Sleep Disorders Center is part of the Outpatient Clinic of the Psychiatry Department. Clinical psychology interns do a four month rotation in the Insomnia Clinic with Rachel Manber, Ph.D., and myself.
*Postdoctoral opportunities: These are individually arranged and depend upon funding.

5. Types Of Funding Available (Trainee Support):

All graduate students admitted into clinical psychology are offered a package that commits to up to 5 years of funding through some combination of teaching assistants, research assistants, and clinical stipends.

6. Types Of Funding Available (Laboratory Grants):

We are participating in the multi-site NIH funded project on sleep apnea and cardiovascular risk.  Also, Derek Loewy has been awarded a B/START grant from NIMH on cognitive processing in insomnia as measured by auditory event-related potentials

7. Number and Names Of Current Trainees: (4)

2 clinical psychology graduate students (4th and 5th year) and 1 postdoctoral fellows.

Graduate students: Steve Rider, Tracy Kuo
Postdoctoral fellows: Derek Loewy

8. Students Who Have Completed Training In The Past Five Years and Current Status :

Rachel Manber, Ph.D. Assistant Professor Department of Psychiatry, University of Arizona.
Michael L. Perlis, Ph.D. Assistant Professor Department of Psychiatry, University of Rochester
Dana Epstein, R.N., Ph.D. Associate Director of Nursing Denver VA Medical Center
Tim Hubbard, Ph.D. Assistant Professor Texas Christian University
James K. Wyatt, Ph.D. Research Fellow Harvard Medical School and Brigham & Women's Hospital

9. Primary Research Focus Of Laboratory :

+ Behavioral treatment of insomnia
+ Sleep and cognitive processing
+ Health, psychopathology, and sleep
+ Circadian rhythms and sleep
+ Aging and sleep

10. Technical Capabilities Of The Lab:

* Two bedroom sleep research lab with 2 Grass Model 8 polygraphs and split screen video
* Automated sleep staging, power spectral analyses, and event related potential software
* 15 wrist actigraphs
* Computer-based reaction time and performance testing

11. Primary Training Focus: Graduate training in clinical psychology.

12. Other Training Opportunities:

University of Arizona Sleep Disorders Center (Stuart Quan, M.D.); Department of Psychiatry, College of Medicine (Iris Bell, M.D., Ph.D., Rachel Manber, Ph.D.), College of Nursing (Claire Parsons, Ph.D.); cognitive neuroscience research, Department of psychology (John Allen, Ph.D., Al Kaszniak, Ph.D., Bruce McNaughton, Ph.D., Gary Schwartz, Ph.D., Cyma Van Petten, Ph.D.).

13. Representative Publications For Last Five Years:

Bootzin, R.R., & Perlis, M.L. (1992).  Nonpharmacological treatments of insomnia.  Journal of Clinical Psychiatry, 53,
Suppl. 6, 37 41.

Wood, J.M., Bootzin, R.R., Rosenhan, D., Nolen Hoeksema, S., & Jourden, F. (1992).  Effects of the 1989 San Francisco
earthquake on frequency and content of nightmares.  Journal of Abnormal Psychology, 101, 219 224.

Bootzin, R.R., Manber, R., Perlis, M.L., Salvio, M., & Wyatt, J.K. (1993).  Sleep disorders.  In P.B. Sutker & H.E. Adams (Eds.),
Comprehensive Handbook of Psychopathology, 2nd Edition.  New York:  Plenum Press.

Wyatt, J.K., Bootzin, R.R., Anthony, J., & Bazant, S. (1994).  Sleep onset is associated with retrograde and anterograde amnesia.
Sleep, 17, 502 511.

Perlis ML, Giles DE, Fleming G, Drummond P, James S  (1995). Sustained facial muscle activity during REM sleep in depressed
subjects and its correlation with self reported  depression. Journal of Affective Disorders, 35, 163-171.

Bell, I.R., Bootzin, R.R., Ritenbaugh, C., Wyatt, J.K., DeGiovanni, G., Kulinovich, T., Anthony, J.L., Kuo, T.F., Rider, S.P.,  Peterson, J.M., Schwartz, G.E., & Johnson, K.A. (1996).  A polysomnographic study of sleep disturbance in community elderly  with self-reported environmental chemical odor intolerance.  Biological Psychiatry, 40, 123-133.

Bootzin, R.R., Epstein, D., Engle-Friedman, M., & Salvio, M. (1996) Sleep disturbances.  In L. Carstensen, B. Edelstein, & L.
Dornband (Eds.),  The Practical Handbook of Clinical Gerontology (pp 398-420).  Thousand Oaks, CA:  Sage Publications.

Manber, R., Bootzin, R.R., Acebo, C., & Carskadon, M.A. (1996).  The effects of regularizing sleep-wake schedules on daytime
sleepiness. Sleep, 19, 432-441.

Manber, R., & Bootzin, R.R. (in press).  Sleep and the menstrual cycle.  Health Psychology.

1. Affiliation: 1996-1997 Entry -  College of Nursing, University of Arizona, Sleep Laboratory

2. Name & Address: L. Claire Parsons, Ph.D.

University of Arizona - College of Nursing
4540 North Trocha Alegre
Tucson, AZ 85750

Phone: (602) 626-4190
FAX: (602) 626-2211;
E-Mail:cparsons@rni.nursing.arizona.edu

3. Other Faculty: University of Arizona Sleep Disorders Center (Stuart Quan, M.D., Collin Bamford, M.D.); Department of Psychiatry (Iris Bell, M.D., Ph.D., Rachel Manber, Ph.D.), Department of Psychology (Richard Bootzin, John Allen, Ph.D., Al Kaszniak, Ph.D., Bruce McNaughton, Ph.D., Gary Schwartz, Ph.D., Cyma Van Pettern, Ph.D.).

4. Type Of Training Available:

Undergraduate: Students are offered independent study in Sleep Disorder Health Care.
Graduate: Students are offered opportunities to take N608 - Cognitive Alterations as well as independent study in an area of interest where ongoing research is in place. Students are also encouraged to enroll in Psychology 528 - Cognitive Neuroscience to enhance their understanding of Event Related Potential Methods.

5. Types Of Funding Available:

Limited funding is available to support both undergraduate and graduate research assistantships. No funds are currently available or anticipated for postdoctoral fellowships for 1995-1996.

6. Current Trainees: Undergraduate: Susan Buxbaum    Graduate Trainees: None

7. Students Who Have Completed Training In The Past Five Years and Current Status:
 

8. Primary Research Focus Of Laboratory:

+ Changes in the Sleep-Awake cycle following Traumatic Brain Injury.
+ Changes in the Sleep-Awake cycle following Triple-Intrathecal Chemotherapy and/or
+ Whole Brain Radiation in Children and Adolescents following Acute Lymphoblastic Leukemia.

9. Technical Capabilities In The Laboratories:

* One bedroom sleep research lab with a Grass Model 78 polygraph, split screen video monitoring and digital PSG capability w/ Power Spectral Analysis.
* One Event Related Potential Laboratory (in the progress of being built. Scheduled for completion: Fall of 1996.)

10. Primary Education Focus: Education in Behavioral and Sleep Research

11. Other Training Opportunities:
 

12. Representative Publications For Last Five Years:

Parsons, L.C. (1993). Head injuries. In Encyclopedia of Sleep and Dreaming (Ed) Mary A. Carskadon. Macmillan Publishing Co., New York.

Parsons, L.C., Crosby, L.J., Jones, P., Moore, I., Hutter, J., Rostad, M., Perlis, M., Applegate, K., Humble, S., & Temes, R. Power Spectral Analysis (PSA): Longitudinal overnight sleep studies in children with leukemia. Associated Sleep Societies, June 7-10, 1993. Boston, M.A.

Parsons, L.C., Perlis, M., Jones, P., Applegate, K., Humble, S., Skinner, T., Temes, R. Townsend, V., Crosby, L.C.,

Moore, I., & Hutter, J. Power Spectral Analysis (PSA) Overnight electroencephaloographic (EEG) sleep studies of children with acute lymphoblastic leukemia (ALL). Soceity for Neuroscience, Nov. 11, 1993. Washington, D.C.

Parsons, L.C. & Moore, I. (1993). Impact of triple intrathecal chemotherapy and/or whole brain radiation on overnight EEG Sleep variables in children with lymphoblastic leukemia. International Nursing Research Conference Sigma Theta Tau, Madrid, Spain, June 21-22, 1993.

Parsons, L.C., Perlis, M., Kwan, T., Khalifa, M., Jones, P. & Crosby, L.J. (1992, May 30-June 3) Power spectral analysis (PSA): Longitudinal overnight studies in minor head injured adolescents. Association for Professional Sleep Researchers, Phoenix, Arizona.

1. Affiliation: 1997-1998 Entry - UCLA & Multisite Training Program

2. Name & Address: Michael H. Chase, Ph.D.

UCLA School of Medicine - Dept. of Physiology
Center For Health Services
Los Angeles, CA 90024-1746

Phone: (310) 825-3417; FAX: (310) 206-3499
E-Mail: mchase@ucla.edu

3. Other Faculty:

William Dement, Ronald Harper, Robert McCarley, Dennis McGinty, Francisco Morales,  Adrian Morrison, Allan Rechtschaffen, Howard Roffwarg, Jerome Siegel and Maurice Sterman
 
4. Type Of Training Available: All areas of neuroscience/basic sleep research.

5. Types Of Funding Available: Pre and Postdoctoral Awards

6. Number and Names Of Current Trainees:  Approximately 12 trainees, names not available for distribution

7. Students Who Have Completed Training In The Past Five Years and Current Status:

3 Graduate Trainees: 3 accepted postdoctoral positions, 1 is a Assistant Scholar in pharmacodynamics.

7 Postdoctoral Trainees: 1 in Psychiatry Residency,; 3 are Assistant Professors at various Universities; 3 are Research Assistant Professors.

8. Primary research focus of laboratory : This multisite training program focuses on all aspects of basic sleep research. Each laboratory involved has a different primary research focus, including, but not limited to:

+ Brainstem and forebrain generation
+ Maintenance and regulation of sleep and wakefulness
+ Sleep and the autonomic nervous system
+ Thermoregulation and sleep
+ Timing of sleep and circadian rhythms and abnormal sleep
+ Ontogeny of sleep
+ Phylogeny of sleep
+ Sleep and cognition
+ Sleep and immune system interactions
+ Sleep and stress interactions
+ Arousal mechanisms
+ Neuropharmacology of the sleep state
+ Sleep factors

9. Technical Capabilities Of The Lab:

Laboratories involved in the training program utilize a variety of techniques, including, but not limited to:

 + In vivo intracellular recording/microiontophoresis
 + PET
 + Microdialysis/HPLC in freely behaving animals
 + SPECT
 + Optical reflectance imaging in the freely behaving animal
 + 2-Deoxyglucose
 + Single and multi=96unit recording in the freely behaving animals
 + Microinjections
 + Functional Magnetic Resonance Imaging
 + Computer modeling
 + Patch clamp recording in vitro
 + Immunohistochemistry techniques
 + EEG, EMG, EOG, EKG recording in the freely behaving animal
 + Neuroimmunology techniques
 + Subtractive hybridization, RFLP, PCR, and other molecular techniques
 
10. Primary Training Focus: Sleep

11. Other Training Opportunities:

Training opportunities in the multisite training program are limited only by the types of laboratories, national and international associated with the program and your own imagination.

12. Representative Publications For Last Five Years:
We recommend a library search of the individual researcher(s) that interest you.

    Dept. of Psychology, UCLA
    405 Hilgard, LA, CA  90024

    Phone:(818)-891-7711,X7579
    FAX: (818)-895-9575;
    E-Mail: dmcginty@ucla.edu

3.  Other Faculty:

4.  Types of Training Available:
 
 * Undergraduate: UCLA undergraduate programs
 * Graduate: UCLA graduate programs: Neuroscience, Biopsychology, Ph.D./MD Joint Program: yes
 * Clinical Internship/Fellowship: No
 * Post-Doctoral: Yes
 * Assistantships: Yes

5.  Types of Funding Available (Trainee Support):   Basic sleep research training grant

6.  Types of Funding  (Laboratory Grants):  NIH and VA grant funds.

7.  Number and Names of Current Trainees:   4
 
 Graduate:  Tim Hays, Jennifer Flett.
 Postdoctoral:  Noor Alam, Ph.D., Teresa Steininger, Ph.D.

8.  Students Who Have Completed Training in the Past Five Years and Current Status:

 Graduate: Stephen Moriarty, postdoctoral position: McCarley Lab.

9.  Primary Clinical or Research Focus of Laboratory:   Chronic neurophysiology, slice neurophysiology, thermoregulation and sleep.

10.  Technical Capabilities of the Laboratory:   See 9, Immunohistochemistry, tracing techniques.

11.  Primary Training Focus:   Basic sleep research.

12.  Other Training Opportunities:  

13.  Representative Publications for Last Five Years:

Morairty, S., Szymusiak, R. Thomson, D., and McGinty, D.  Selective increases in non-rapid eye movement sleep following whole body warming in rats.  Brain Res. 617, 10-16, 1993.

McGinty, D., Szymusiak, R, and Thomson, D. Preoptic/anterior hypothalamic warming increases EEG delta frequency activity within non-rapid eye movement sleep.  Brain Res. 667, 273-277, 1994.

Alam, N., McGinty, D., and Szymusiak, R. Neuronal discharge of preoptic/anterior hypothalamic neurons: relation to NREM sleep. Am. J. Physiol. 269, R1240-R1249, 1995.

Alam, N. Szymusiak, R, and McGinty, D. Local preoptic/anterior hypothalamic warming alters spontaneous and evoked neuronal activity in the mago-cellular basal forebrain.  Brain Res. 696, 221-230, 1995.

Hays, T., Morairty, S., Szymusiak, R., and McGinty, D. The effects of temperature and synaptic blockade in vitro on neurons of the horizontal limb of the diagonal band of Broca in the rat basal forebrain.  Brain Res.  746, 52-58, 1997.

1. Affiliation: 1995-1996 Entry - Neurobiology Research, Department of Psychiatry University of California - Los Angeles

2. Name & Address: Jerry Siegel, Ph.D.

Sepulveda VA Medical Center -Neurobiology Research 151A3
Sepulveda VA Medical Center
Sepulveda, CA 91343

Phone: (818) 891-7711, ext. 7580; FAX: (818) 895-9575
E-Mail: jsiegel@ucla.edu

3. Other Faculty: Member of National Multisite Training Program and Oro­motor training program, NIH grant support.

4. Type Of Training Available: Basic neurobiology of sleep.

5. Types Of Funding Available: NIH predoc and postdoc slots.

6. Number and Names Of Current Trainees: Jun Kohyana (Post-Doc); San Ouyanof (Posrt­Doc); T. Hajnik (Pre-Doc).

7. Students Who Have Completed Training In The Past Five Years and Current Status:
 

8. Primary Research Focus Of Laboratory:

+ Basic mechanisms of REM sleep
+ Narcolepsy
+ Evolution of sleep

9. Technical Capabilities Of The Laboratory:

* Extra and intracellular recording
* Immunohistochemistry, phylogeny, a broad range of acute and chronic physiological techniques.
* In vivo microdialysis

10. Primary Training Focus: Basic sleep mechanisms.

11. Other Training Opportunities: Available through National Multisite Training Program.
 
12. Representative Publications For Last Five Years:

Lai, Y. Y., Siegel, J. M. Cardiovascular and muscle tone changes produced by microinjection of cholinergic and glutamatergic agonists in dorsolateral pons an medial medulla. Brain Res. 514:27­36, 1990.

Shiromani, P. J., Lai, Y. Y., and Siegel, J. M. Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat. Brain Res. 517:224­228, 1990.

Lai, Y.Y. and Siegel, J.M. Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J. Neurosci. 12734, 1990.

Wu, M.F., Siegel, J.M., Shouse, M.N. and Schenkel, E. Lesions producing REM sleep without atonia disinhibit the acoustic startle reflex without affecting prepulse inhibition. Brain Res. 528:330­334, 1990.

Wu, M.F., and Siegel, J.M. Facilitation of the acoustic startle reflex by ponto­geniculo­occipital waves: effects of PCPA. Brain Res. 532:237­241, 1990.

Mallick, B.N., Fahringer, H., Wu, M.F. and Siegel, J.M. REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons. Brain Res. 552:333­337, 1991.

Siegel, J.M., Nienhuis, R., Fahringer, H.M., Paul, R., Shiromani, P., Dement, W. Mignot, E., Chiu, C. Neuronal activity in narcolepsy: identification of cataplex related cells in the medial medulla. Science 262:1315­1318, 1991.

Lai, Y.Y. and Siegel, J.M. Ponto­medullary glutamate receptors mediating locomotor and muscle tone suppression J. Neurosci. 11:2931­2937, 1991

Shouse, M.N. and Siegel, J.M. Pontine regulation of REM sleep components in cats Integrity of the pedunculopontine tegmentum (PPT) is important for phasic events unnecessary for atonia during REM sleep. Brain Res. 571:50­63, 1992.

Siegel, J.M., Nienhuis, R., Fahringer, H.M., Chiu, C., Dement, W.C., Mignot, E., Lufkin, R. Activity of medial mesopontine units during cataplexy and sleep­wakin states in the narcoleptic dog. J. Neurosci. 12:1640­1646, 1992.

Lai, Y.Y., and Siegel, J.M. Corticotropin­releasing factor mediated muscle atonia pons and medulla. Brain Res. 575: 63­68, 1992.

Kodama, T., Lai, Y.Y. and Siegel, J.M. Enhancement of acetylcholine release during REM sleep in the caudo­medial medulla measured by in vivo microdialysis. Brain Res. 580:348­350, 1992.

Lai, Y.Y., Clements, J.R. and Siegel, J.M. Glutamatergic and cholinergic project to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry. J. Comp. Neurol. 336:321­330, 1993.

Siegel, J. M. Brainstem mechanisms generating REM sleep. In: Principals and Practice of Sleep Medicine, Second Edition. edited by M. K. Kryger, T. Roth, W. Dement. New York: Saunders, 125­144, 1994.

1. Affiliation: 1997-1998 Entry - UCSD School of Medicine The University of California San Diego / San Diego State University Joint Doctoral Program - University of California, San Diego School of Medicine

2. Name & Address:

Joint Doctoral Program in Clinical Psychology
6363 Alvarado Ct., Ste. 103, San Diego. Ca 9218

Medical Scientist Training Program, UCSD School of Medicine
Office of Student Affairs 0606
9500 Gilman Drive, La Jolla, Ca 92093-0606

Neuroscience Department 0624
9500 Gilman Drive, La Jolla, Ca 92093-0624
Phone: (619)-534-3377

Fellowship in Clinical Psychopharmacology and Psychobiology
Department of Psychiatry 9116A, San Diego VA Medical Center
3350 La Jolla Village Drive, San Diego, CA 92161
Phone:  (619)-552-8585 x2742

3. Faculty:

Sonia Ancoli­Israel, Ph.D., Jack Clausen, M.D., Joel Dimsdale, M.D., J. Christian Gillin, M.D., Michael Irwin, M.D., Daniel F. Kripke, M.D., Barbara L. Parry, M.D.

4. Type Of Training Available:

* Graduate education - Clinical and Research Psychology
* Graduate training in Neuroscience
* Psychology internships
* Psychiatry residency and fellowships
* Fellowship - clinical psychopharmacology & psychobiology
* Post­Doctoral fellowships

5. Types Of Funding Available:

Psychology graduate students receive $10,000/year the first year, $11,000 subsequent years as research assistants
(20 hours per week). Salaries for post-doctoral fellowships and psychiatry fellows - contact individual faculty

6. Number and Names Of Current Trainees:

 Graduate Students: Tim Coy, Carl Stepnowsky, Sean Drummond, Erin Hoese, Polly Moore, Halli ThorMaria Andujo Hanger, Ph.D.

 Post-Doctoral Fellows:  Camillia Clark, M.D., Ruth Pat-Horenczyk, Ph.D., Sean Youngstedt, Ph.D.,Tahir Bhatti, M.D., Erich Siefritz, M.D.
 
7. Students Completing Training In Past Five Years:

Maria Andujo Hanger, Ph.D.  Completed post-doctoral fellowship and is teaching at college level
Rachel Morehouse, M.D.   Director of Sleep Disorders Clinic in Halifax, Nova Scotia
Clete Kushida, M.D.   Completing fellowship in Sleep Medicine
Rebecca Zoltoski, Ph.D.   Research Scientist, Brock University

8. Primary Research Focus Of Laboratory(s):

Aging, alcoholism and substance abuse, biofeedback, brain imaging, cholinergic systems, circadian oscillators,  cross-ethnic prevalence of sleep disorders, depression, epidemiology, genetics, hypnotics and treatment of insomnia, immunology, light treatment, menopause, premenstrual dysphoric disorder, psychobiology, psychopharmacology, sleep apnea, sleep disorders, women's medicine.

9. Technical Capabilities Of The Lab:

+  Ambulatory recordings (unattended monitoring)
+  Actigraphy
+  Brain Imaging
+  Sound Chambers
+  Wet lab
+  Sleep Lab
+  UCSD Mental Health Clinical Research Center
+  UCSD Geropsychiatry Clinical Research Center
+  Digitized EEG analysis
+  Human temporal isolation
 
10. Primary Training Focus:

* Graduate training in Clinical Psychology
* UCSD Fellowship in Clinical Psychopharmacology and Psychobiology
* Post-doctoral training in Sleep Medicine and Sleep Research

11. Other Training Opportunities:

San Diego State University, Salk Institute, The Research Institute of Scripps Clinic and the Naval Health Research Center

12. Representative Publications For Past Five Years:

Ancoli-Israel, S., Engler, R.L., Friedman, P.J., Klauber, M.R., Ross, P.A., and Kripke, D.F.  Comparison of patients with central sleep apnea: with and without cheyne-stroke respiration.  Chest 6(3):780-786, 1994.

Ancoli-Israel, S., Klauber, M.R., Butters, N., Parker, L., and Kripke, D.F.  Dementia in institutionalized elderly:  Relation to sleep apnea.  J. Am. Geriatr. Soc.  39(3):258-263, 1991.

Ancoli-Israel, S., Klauber, M.R., Gillin, J.C., Campbell, S.S., and Hofstetter, C.R.  Sleep in non-institutionalized Alzheimer's disease patients.  Aging Clin. Exp. Res.  6:451-458, 1994.

Ancoli-Israel, S., Klauber, M.R., Stepnowsky, C., Estline, E., Chinn, A., and Fell, R.  Sleep disordered breathing in African-American elderly.  Am. J. Resp. Crit. Care Med.  in press:1995.

Ancoli-Israel, S., Kripke, D.F., Klauber, M.R., Parker, L., Stepnowsky, C., Kullen, A.S., and Fell, R.  Natural history of sleep disordered breathing in community dwelling elderly.  Sleep  16(8):S25-S29, 1993.

Coy, T.V., Dimsdale, J., Ancoli-Israel, S., and Clausen, J.  The role of sleep disordered breathing in essential hypertension.  Chest  1996.

Dimsdale, J.E., Coy, T., Ziegler, M.G., Ancoli-Israel, S., and Clausen, J.  The effect of sleep apnea on plasma and urinary catecholamines. Sleep  18:377-381, 1995.

Espiritu, R.C., Kripke, D.F., Ancoli-Israel, S., Mowen, M.A., Mason, W.J., Fell, R.L., Klauber, M.R., and Kaplan, O.J.  Low illumination by San Diego adults: Association with atypical depressive symptoms.  Biol. Psychiatry  35:403-407, 1994.

Hong CCH, Gillin JC, Dow BM, Wu J, Buchsbaum MS.  Localized and laterilized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study.  Sleep, 1995, 18:570-580.

Gillin JC, Buchsbaum MS, Valladares-Neto DC, Hong CCH, Hazlett E, Langer SZ and Wu J.  Effects of zolpidem on cerebral glucose metabolism during nonREM sleep in normal volunteers: A positron emission tomography study.  |Neuropsychopharmacology, 1996, in press.

Gillin, JC, Ho, AP, Buchsbaum, MS, Wu, J, Abel, L, Bunney, JR W  Functional brain imaging, sleep, and sleep deprivation: contributions to the "overarousal" hypothesis of depression.  Acta Neuropsychiatrica , 1995, 7:33-34.

Gillin, JC, Jernajczyk W, Valladares-Neto DC, Golshan S, Lardon M, Stahl, S.  Inhibition of REM sleep by ipsapirone, a 5HT1A agonist, in normal volunteers.  Psychopharmacology 1994, 116:433-436.

Gillin, JC, Smith TL, Irwin, M, Irwin, M, Butters, N, Demodena, A, Schuckit, M.  Increased pressure of REM sleep at time of hospital admission predicts relapse in nondepressed patients with primary alcoholism at three month followup.  Arch Gen Psychiatry  51:189-197; 1994.

Ho, AP, Gillin, JC, Buchsbaum, M, Wu, J, Abel, L, Bunney JR W  Elevated cerebral glucose metabolism during non-rapid eye movement    sleep in major depression: a positron emmission tomography study.  Arch Gen Psychiatry (in press).

Irwin, M, Mascovich, A, Gillin, JC, Willoughby, R, Pike, J and Smith, TL.  Partial sleep deprivation reduces natural killer cell activity in humans. Psychosomatic Med, 1994, 56:493-498.

Irwin, M., Smith, T.L., and Gillin, J.C.  Electroencephalographic sleep and natural killer activity in depressed patients and control subjects.  Psychosom. Med.  54(1):10-21, 1992.

Kripke, D.F.  Timing of phototherapy and occurrence of mania.  Biol. Psychiatry  29:1156-1157, 1991.

Kripke, D.F. and Elliott, J.A.  Can light augment melatonin? In: Touitou, Y., Arendt, J. and Pevet, P. (eds.) Melatonin and the Pineal Gland: From Basic Science to Clinical Application.  Amsterdam: Elsevier, 1993, pp. 211-214.

Kripke, D.F., Mullaney, D.J., Klauber, M.R., Risch, S.C., and Gillin, J.C.  Controlled trial of bright light for nonseasonal major depressive disorders.  Biol. Psychiatry  31:119-134, 1992.

Lovell, B.B., Ancoli-Israel, S., and Gevirtz, R.  The effect of bright light treatment on agitated behavior in institutionalized elderly.  Psychiatry Res.  57:7-12, 1995.

Moeller RG, Gillin JC, Irwin M, Golshan S, Kripke DF, Schuckit M. A comparison of sleep EEGs in patients with primary depression and majory depression secondary to alcholism.  J Affect Dis, 1993, 27:39-42.

Parry, B.L., Cover, H., Mostofi, N., LeVeau, B., Sependa, P.A., Resnick, A., and Gillin, J.C.  Early versus late partial sleep deprivation in patients with premenstrual dysphoric disorder and normal comparison subjects.  Am. J. Psychiatry  152:404-412, 1995.

Parry, BL, Hauger, R, Lin, E, Le Veau, B, Mostofi, N, Clopton, PL and Gillin, JC.  Neuroendocrine effects of light therapy in late luteal phase dysphoric disorder.  Biological Psychiatry, 1994, 36(6):356-364.

1. Affiliation: 1997-1998 Entry - National Center For PTSD and Psychology Service, Palo Alto VAMC

2. Name & Address: Steven H. Woodward

     Sleep Lab-National Center For Post-Traumatic Stress Disorder
     VAMC, Mail Code 323D6
     3801 Miranda Avenue
     Palo Alto, CA  94304
 
     Phone: (415)-493-5000, ext. 22111; FAX: (415)-617-2769
     E-Mail: woodward@icon.palo-alto.med.va.gov

3. Other Faculty::

M. Michele Murburg, M.D. (sympathetic neurobiology of PTSD - VA funded), Frances R. Abueg, Ph.D. psychophysiology and relapse prevention therapy outcome - NIDA funded).  Approximately ten full-time doctoral-level clinicians specializing in PTSD.

4. Types Of Training Available:

Computer-based sleep research in PTSD, sleep ERPs, waking ERPs

5. Types Of Funding Available:

* No training funding in place.  Student-initiated fellowships welcome.

6.  Types of Funding Available (Laboratory Grants):

 * VA Merit Review:  Ambulatory Monitoring in PTSD
 * Sleep and Startle Monozygotic Twins Discordant for PTSD (Richard Ross, PI - we are one site for this project)

7. Number and Names Of Current Trainees: None

8. Students Who Have Completed Training In The Past Five Years and Current Status : None

9. Primary Research Focus Of Laboratory :

+ Sleep disturbance in PTSD

10. Technical Capabilities Of The Lab:

*  Two temperature-controlled sleep rooms equipped with Grass model 7 polygraphs
*  DATAQ Codas-based 16-channel data acquisition systems
*  Low-light video/audio recording
*  Equipment and software necessary for recording and quantitative analysis of a wide array of biosignals including BEG,
   EMG, EOG, HR, RR, SCL/SCR, SP, and body position
*  Additional equipment and software necessary for presentation of auditory and visual stimuli and for 64-channel recording of
   sleep and waking ERPs
*  Non-lab sleep using the new all-digital Medilog MR95 as well as ambulatory impedance cardiography.

11. Primary Training Focus:

Sleep in PTSD and related psychopathology, advanced signal processing in sleep research, relation of sleep   psychophysiology to waking mood, behavior, and cognition.

12. Other Training Opportunities:

Combat-related PTSD inpatient treatment including milieu treatment, various trauma-focused, relapse preventative, and psychoeducational interventions; advanced psychometric and psychophysiologic assessment of PTSD..

13. Representative Publications For Last Five Years:

Woodward, SH, Owens, J, Thompson, L (1990).  Word-to-word variation in ERP component latencies: Spoken words.  Brain & Language, 38: 488-503.

Woodward, S, Brown, W, Marsh, JT, Dawson, M (1991).  Probing the time-course of the auditory oddball P3 with secondary reaction time.  Psychophysiology, 28: 609-618.

Woodward, SH, Ford, JM, Hammett, SJ   N4 to spoken sentences: Associations with aging, attention, and memory.  Electroencephalography and Clinical Neurophysiology,  87: 306-320.

Blake, DD, Abueg, FR, Woodward, SH.  Treatment efficacy in post-traumatic stress disorder in Giles, TR (Ed) Handbook of Effective Psychotherapy.  New York: Plenum, 1994.  In press.

Woodward, SH, Bliwise, DL, Friedman, MJ, Gusman, DF.  Subjective versus objective sleep in Vietnam combat veterans hospitalized for PTSD.  Journal of  Traumatic Stress,  In press.

Woodward, SH.  Neurobiological perspectives on sleep in PTSD.  In: Friedman, MJ, Charney, DS, Deutch, A. (Eds)  Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD (in press).

Woodward SH, Murburg, MM.  Sleep disturbance in postraumatic stress disorder.  In: Miller, DJ. (Ed).  Handbook of Traumatic Stress Disorders (in press).

Woodward, SH, Friedman, MJ, Bliwise, DL.  Sleep and depression in combat-related PTSD inpatients (in press).
 

1. Affiliation: 1995-1996 Entry - San Jose State University, Department of Psychology

2. Name & Address:  Robert A. Hicks

San Jose State University, Department of Psychology
San Jose, CA  95192-0129
 
Phone: (408)-924-5699;
FAX: (408)-924-5657;
E-Mail: rhicks@sjsuvm1.sjsu.edu
 
3. Other Faculty::  Nathan Philips, Ph.D. (Psychology) and Sally Veregge, Ph.D. (Biological Sciences)

4. Types Of Training Available:

* Ungraduate and M.A. level graduate studies
* Independent studies (Undergraduate +/or Graduate Levels) with members of the faculty
* Undergraduate and Graduate research assistantships

5. Types Of Funding Available:

Both undergraduate and graduate level research assistantships that are funded by research grants and a variety of university funded programs that are available to matriculated students on a competitive basis.

6. Number and Names Of Current Trainees:
 

7. Students Who Have Completed Training In The Past Five Years and Current Status :
 

8. Primary Research Focus Of Laboratory :

+  Sleep -  behavioral relationships
+  Circadian rhythmns and sleep

9. Technical Capabilities Of The Lab:

*  Animal colony, surgery
*  Well-equipped lab designed to measure, record and evaluate behavioral and electrophysiological responses

10. Primary Training Focus: M.A. level training in psychobiology.

11. Other Training Opportunities: At present no other formal training opportunities are available.

12. Representative Publications For Last Five Years:

Lucero, K. & Hicks, R.A. (1990).  Relationship between habitual sleep duration and diet.  Perceptual and Motor Skills,
71: 1377-1378.

Show, P., Puentes, J., Reis, C. & Hicks, R.A. (1990).  REM sleep deprivation fails to increase aggression in female rats. Bulletin of the Psychonomic Society, 28: 448-450.

Martinez, R., Bautista, J., Phillips, N. & Hicks, R.A. (1991).  REM sleep deprivation and the food consumption patterns
of male rats.  Bulletin of the Psychonomic Society, 29: 421-424.

Lexcen, F.J. & Hicks, R.A. (1993).  Does cigarette smoking increase sleep problems?  Perceptual and Motor Skills, 77: 16-18.

Brassington, G.S. & Hicks, R.A. (1995).  Aerobic exercise and self-reported sleep quality in elderly individuals.  Journal of Aging and Physical Activity.  In press
.

1. Affiliation: 1996-1997 Entry - Stanford University Medical Center

Stanford Sleep Disorders Clinic

2. Name & Address: Alex A. Clerk, M.D., Director

401 Quarry Road, Suite 3301
Stanford, California 94305-5547

Phone: (415) 723-6601,
FAX: (415) 725-7341,
E-Mail: clete@leland.Stanford.EDU

3. Other Faculty: Christian Guilleminault, M.D., Rafael Pelayo, M.D., Jed Black, M.D., Clete Kushida, M.D., Ph.D.

4. Types Of Training Available:

*Undergraduate research assistantships
*Postdoctoral opportunities: There are postdoctoral clinical and research opportunities.

5. Types Of Funding Available:
 

6. Number and Names Of Current Trainees: (1) Postdoctoral fellow: Anstella Robinson, M.D.

7. Students Who Have Completed Training In The Past Five Years and Current Status :
 

8. Primary Research Focus Of Laboratory :

+ Intensive investigation into sleep-disordered breathing problems
+ Behavioral treatment of insomnia

9. Technical Capabilities Of The Lab:

+ Six bedroom sleep research lab
+ Extensive computer capabilities for automated sleep staging and analysis
+ Six ambulatory monitoring systems
+ 3 wrist actigraphs

10. Primary Training Focus: Postgraduate training in sleep medicine.

11. Other Training Opportunities: Stanford Sleep Research Center

12. Representative Publications For Last Five Years:

Guilleminault C, Stoohs R, Clerk A, Simmons J, Labanowski M. From obstructive sleep apnea syndrome to upper airway resistance syndrome: consistency of daytime sleepiness. Sleep 15:S13-S16, 1992.

Guilleminault C, Crowe-McCann C, Quera-Salva MA, Cetel M. Light therapy as treatment of dyschronosis in brain-impaired children.
Eur J Pediatr 152:754-759, 1993.

Guilleminault C, Clerk A, Labanowski M, Simmons J, Stoohs R. Cardiac failure and benzodiazepines. Sleep 16(6):524-528, 1993.

Guilleminault C, Stoohs R, Skrobal A, Labanowski M, Simmons J. Upper airway resistance in infants at risk for sudden infant death syndrome. J Pediatr 122: 881-886, 1993.

Clerk A, Duncan SR, Guilleminault C. Load detection in subjects with sleep-induced upper airway obstruction. Am J Respir Crit Care Med 149:727-730, 1994.

Chervin RD, Guilleminault C. Diaphragm pacing: review and reassessment. Sleep 17:176-187, 1994.

Guilleminault C, Mignot E, Partinen M. Controversies on the diagnosis of narcolepsy. Sleep 1994;17:S1-S6.

Guilleminault C, Powell N, Bowman B, Stoohs R. The effect of electrical stimulations on obstructive sleep apnea syndrome. Chest 1995;107:67-73.

Guilleminault C, Stoohs R, Labanowski M, Simmons J, Clerk A. Cardiac failure, snoring, ventricular arrhythmias and nasal bilevel positive pressure ventilation. Sleep 1993; 16:S139-S140.

Chervin R, Guilleminault C. Ambulatory monitoring of blood pressure in patients with sleep-disordered breathing. J Cardiovascular Risk 1:127-131, 1994.

Guilleminault C, Stoohs R, Clerk A, Simmons J, Labanowski M. Excessive daytime somnolence in women with abnormal respiratory efforts during sleep. Sleep 1993;16:S137-138.

Guilleminault C, Clerk A, Black J, Labanowski M, Pelayo R, Claman D. Non-drug treatment trials in psychophysiological insomnia. Arch Int Med 1995;155:838-844.

Guilleminault C, Stoohs R. Arousal, increased respiratory efforts, blood pressure and obstructive sleep apnea. J Sleep Res 1995;4: S117-S124.

Guilleminault C, Partinen M, Hollman K, Powell NB, Stoohs R. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995;107:1545-1551.

Guilleminault C, Moscovitch A, Leger D. Injury, violence and nocturnal wanderings. Am J Forensic Psych 1995;16:33-45.

Guilleminault C, Moscovitch A, Leger D. Forensic sleep medicine: nocturnal wandering and violence. Sleep 1995;17:740-748 .

Guilleminault C, Stoohs R, Kim Y, Chervin R, Black J, Clerk A. Sleep-related upper airway disordered breathing in women. Ann Int Med 1995;122:493-501.

Guilleminault C, Leger D, Pelayo R, Gould S, Hayes B, Miles L. Development of circadian rhythmicity of temperature in full-term normal infants. Clin Neurophysiol 1995;127:905-912.

Guilleminault C, Pelayo R, Clerk A, Leger D, Bocian RC. Home nasal continuous positive airway pressure in infants with sleep-disordered breathing. J Pediatrics 1996 (in press).

Kushida CA, Clerk AA, Kirsch CM, Hotson JR, Guilleminault C. Prolonged confusion with nocturnal wandering arising from NREM and REM sleep: A case report. Sleep 1995;18:757-764.

Guilleminault C, Kushida CA, Leger D. Forensic sleep medicine and nocturnal wandering. Sleep 1995;18:721-723.

Chervin RD, Kraemer HC, Guilleminault C. Correlates of sleep latency on the multiple sleep latency test in a clinical population. Electroencephalogr Clin Neurophysiol 1995;95:147-153.

1. Affiliation:  1997-1998 Entry -  Center for Sleep and Circadian Neurobiology, Department of Biological Sciences, Stanford University

2. Name & Address: H. Craig Heller

Stanford University
Gilbert 420A
Stanford, CA 94305-5020

Phone: (415) 723-1509;
FAX: (415) 725-5356

3. Other Faculty: No information provided.

4. Training Available: Undergraduate, Graduate, and Postgraduate

5. Funding Available: Graduate funding dependent upon departmental admissions. Postgraduate usually depends on application of fellow.

6. Current Trainees:

Graduate:  Laure Haak, Roger Morrissette
Postgraduate: Norman Ruby, Hilary Srere, Christelle Peyron, Chiaki Fukuhara

7. Recent Graduate and Postdoctoral Trainees:

 Marcos Frank    Postdoc. Fellow      University of Cal.,S.F.
 Paul Franken    Scientist  University of Zurich
 Joel Benington   Assistant Prof. Biology St.Bonaventure Univ.
 Rebecca Prosser  Assistant Prof.   University of Tennessee
 Lorenz Trachsel  Scientist   Max Planck Inst., Munich
 Nancy Berner   Assistant Prof.    University of the South
 
8. Primary Research Focus Of Laboratory:

  *  The neurobiology of sleep and circadian rhythms and their interactions
  *  The functions and control of sleep states
  *  The development and aging of sleep and circadian rhythms controls
  *  Mammalian hibernation
 
9. Technical Capabilities: Molecular to behavioral methods are routinely used.

10. Training Focus: Basic research

11. Other Training Opportunities: MD/PhD program

12. Representative Publications For Last Five Years:

Prosser, R.A., Heller, H.C., Miller, J.D.  Serotonergic phase advances of the mammalian circadian clock involve protein kinase A and  K+ channel opening.  Brain Res 644:67-73, 1994.

Rangarajan, R.,, Heller, H.C., Miller, J.D.  Chloride channel block phase advances the single-unit activity rhythm in the SCN.  Brain Res Bull 34:69-72, 1994.

Grahn, D.A., Miller, J.D., Heller, H.C.  Persistence of circadian rhythmicity in hibernating ground squirrels.  Am J Physiol.
266:R1251-1258, 1994.

Miller, J.D., Cao, V.H., Heller, H.C.  Temperature effects on neuronal activity in the suprachiasmatic nucleus of hibernators and non-hibernators. Am J Physiol.  266:R1259-1266, 1994.

Bitting, L., E.L. Sutin, F.L. Watson, L.E. Leard, B.F. O'Hara, H.C.Heller and T.S. Kilduff. C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation. Neurosci Lett 165: 117-121, 1994.

Leard, L., E.S. Macdonald, H.C. Heller and T.S. Kilduff.  Ontogeny of photic-induced c-fos mRNA in the rat suprachiasmatic nuclei. Neuroreport 5:2683-2687, 1994.

Prosser, R.A., Edgar, D.M, Heller, H.C., Miller, J.D., A possible glial role in the mammalian circadian clock. Brain Res 643:296-301, 1994.

Benington, J. H., Heller, H. C. REM-sleep timing is controlled homeostatically by accumulation of REM-sleep propensity in non-REM sleep. Am. J. Physiol. 266: R1992-R2000, 1994.

Benington, J. H., Kodali, S. K., and Heller, H. C.  Scoring transitions to REM-sleep in rats based on the EEG phenomena of pre-REM-sleep: an improved analysis of sleep structure.  Sleep 17:28-36, 1994.

Clegg, D.A., B.F. O'Hara, H.C. Heller and T.S. Kilduff  Nicotine administration differentially affects gene expression in the maternal and fetal circadian clock.  Develop. Brain Res. 84:46-54, 1995.

O'Hara, B.F., R. Andretic, H.C. Heller, D.B. Carter, and T. S. Kilduff (1995).  GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.  Mol Brain Res. 28:239-250.

Benington, J.H., and Heller, H.C. Does the function of REM sleep concern nonREM sleep or waking?  Prog. in Neurobiol. 44:433-449, 1995.

Benington, J.H., and Heller, H.C. Restoration of brain energy metabolism as the function of sleep.  Prog. in Neurobiol. 45:347-360, 1995.

Trachsel, L., Heller, H.C., Miller, J.D. Nicotine phase advances the circadian neuronal activity rhythm in rat suprachiasmatic nuclei explants.  Neuroscience 65:797-803, 1995.

Benington, J.H., Woudenberg, M.C., and Heller, H.C. (1995) Apamin a selective SK potassium channel blocker, suppresses REM sleep without a compensatory rebound.  Brain Res.  692:86-92

Benington, J.H., Kodali, S.K., and Heller, H.C.  (1995) Stimulation of A1 adensosine receptors mimics the electroencephalographic effects of sleep deprivation.  Brain Res. 692:79-85.

Obrietan, K., Belousov, A. B., Heller, H. C., and van den Pol, A. N.  Adenosine pre- and postsynaptic modulation of glutamate-dependent calcium activity in hypothalamic neurons.  J. Neurophysiology 74(5):2150-2162.

Larkin, J. E. and Heller, H.C. (1996)  Temperature sensitivity of sleep homeostasis during hibernation in the golden-mantled ground squirrel (Spermophilus lateralis).  Am. J. Physiol. 270:R777-R784.

Ruby, N.F. and Heller, H.C. (1996)  Temperature sensitivity of the suprachiasmatic nucleus of ground squirrels and rats in vitro.
J. Biol. Rhythms 11(2):127-137.

Ruby, N.F., Dark, J., Heller, H. Craig, and Zucker, I.  (1996) Ablation of suprachiasmatic nucleus alters timing of hibernation in ground squirrels.  Proc. Natl. Acad. Sci. USA 93:9864-9868.

Ruby, N.F., Saran, A., Kang, T, Franken, P., and Heller, H.C. (1996)  Siberian hamsters free run or become arrhythmic after a phase delay of the photocycle.  Am. J. Physiol. 40(4):R881-R876.

Haak, L.L., Heller, H.C., and van den Pol, A.N.  (1997) Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes.  J. Neurosci. 17(5):1825-1837.

1. Affiliation: 1997-1998 Entry - Department of Physiology and Biophysics University of Tennessee

2. Name & Address: James M. Krueger

College of Veterinary Medicine
Department of UCAPP
Pullman, WA 99164-6520
 
Phone: (509) 335-6624; FAX: (509) 335-4650
E-Mail: krueger@vetmed.wsu.edu

3. Other Faculty: Jidong Fang

4. Type Of Training Available: Undergraduate, Graduate, Post-Doctoral

5. Tyes Of Funding Available (Trainee Support): NIH - F31 type grants

6. Tyes Of Funding (Laboratory Grants): NIH - R-01 type grants

7. Number and Names Of Current Trainees: P. Toishi, Z. Chen, T. Kushikata, J. Gordi, M. Hansen, J. Zhang

8. Students Who Have Completed Training In The Past Five Years and Current Status:

• Levento Kapas,  Associate Professor  Fordham University
•  Mark Opp,  Assistant Professor   Univ. Texas
•  Lars Johanssen,  Research Scientist   Bayer, Germany
•  Luca Imari,   Assistant Professor  Univ. Milano
•  Alan Cady,   Assistant Professor   Miami University of Ohio
•  Satouhi Takahashi, Assistant Professor  Hirosaki Medical Center, Japan

10. Technical Capabilities Of The Lab:

• sleep recordings
• molecular biology
• immunology techniques, cytokine measurements

12. Other Training Opportunities: Immunology/infectious diseases

13. Representative Publications For Last Five Years:

• Krueger, JM and JA Majde.  Microbial products and cytokines in sleep and fever regulation.  Crit. Rev. In Immunology 14:355-379, 994.
• Krueger, JM and F. Obal Jr. Sleep Factors. In: Sleep and Breathing, NA  Saunders and CE Sullivan (eds). Marcel Dkker, Inc., New York, PP 79-112, 1994.
• Krueger, JM and F. Obal Jr.  A neuronal group theory of sleep function.  J Sleep Res.2:63-69, 1993.
• Fincher, E.F., M.J. Pabst and J.M. Krueger.  Neutrophils but not monocytes or microglia degrade interleukin.  Neuroimmunomodulation, 3:  82-86, 1996.
• Bradow, S., P. Tanhi, F. Obal Jr., N Guha-Thakurta and JM Krueger.  Hypothalmic growth hormone-releasing hormone (GHRH) in RNA varies across the day in rats.  Neuro Report 7:2501-2505, 1996.
• Talcahashi, S. et al.  An interleukin receptor fragment inhibits spontaneous sleep and muramyldipeptide-induced sleep in Rabbits.  Am. J.  Physiol. 271:R101-R108, 1996.
• Toth, LA et al. Sleep during experimental trypanosomiasis in rabbits.   Proc. Soc. Expt. Med. Biol.  205:174-181, 1994.

- 49 -

2. Name & Address:  Michael V. Vitiello, Ph.D.

University of Washington - Department of Psychiatry
P.O. Box 356560
Seattle, WA 98195-9520

Phone: (206) 543-7549;
FAX: (206) 543-9520;
E-Mail: vitiello@u.washington.edu

3. Other Faculty: Patricia Prinz, Ph.D., Larry Larsen, Ph.D., Karen E. Moe, Ph.D., David Avery, M.D. Joan Shaver, Ph.D., Martha Lentz, Ph.D., Carol Landis, Ph.D. (Department of Physiological Nursing).

4. Type Of Training Available:

* Undergraduate: Psych 448 ­ Biopsychology of Sleep and Circadian Rhythms
* Graduate: training through the Department of Psychology (either in the Physiological or Clinical Programs), the Multidisciplinary Behavioral Neuroscience Program and the Schools of Medicine and Nursing
* Post Doctoral: Ocassional opportunities when funding is available

5. Types Of Funding Available:

Funding for graduate training is available through individuals parent programs. Sleep specific Graduate Research Assistanceships are rarely available

6. Number and Names Of Current Trainees:

Graduate Students (Psychology): Richard Abrams, Derek Eder, Emily Yamada

7. Students Who Have Completed Training In The Past Five Years:
 

8. Primary Research Focus Of The Laboratory :

+ Sleep and biological rhythms in aging
+ Causes, consequences and treatments of age­related sleep change
+ Sleep, cognition and neuroendocrine relationships in aging
+ The Sleep EEG as a biomarker for early Alzheimer's Disease
+ Spectral Analysis of the sleep EEG

9. Technical Capabilities Of The Laboratory:

* Two bed sleep facility on the Clinical Research Center,
* UWMC Continuous remote blood sampling
* On­line EEG digitization and computer sleep scoring and EEG analysis
* Spectral and related computational analyses of the sleep EEG

10. Primary Training Focus: No primary training focus.

11. Other Training Opportunities: See #4

12. Representative Publications For Last Five Years:

Vitiello, et al.: Nighttime hypoxemia is increased in abstaining chronic alcoholic men. Alcoholism: Clin. Exp. Res. 14(1):38­41, 1990.

Vitiello, et al.: Sleep disturbances in patients with mild­stage Alzheimer's Disease: J. of Gerontol. 45(4):M131­M138, 1990.

Moe, et al.: Healthy elderly men and women have different entrained circadian rhythms. J. Am. Geriatr. Soc. 39:383­387, 1991.

Vitiello and Prinz: Sleep disturbances in the elderly. In: Albert and Knoefel (eds.), Clinical Neurology of Aging. 2nd Ed. Oxford, Press, New York, 637­650, 1994.

Prinz, et al.: C STAGE, automated sleep scoring development and validation with human sleep scoring for healthy older men and women. Sleep 17(8):711­717, 1994.

Larsen, et al., A note on the night­to­ night stability of stages 3+4 sleep in healthy older adults: a comparison of visual and spectral evaluations of stage 3+4 sleep. Sleep 18, 1995 (in press).

Landis, C.A., Savage, M., Lentz, M., Brengelmann, G. Sleep deprivation alters body temperature level and dynamics, not the threshold for sweating. Sleep Research 24, (1995), (in press).

Weiss, M.L., Smith, J., Sokhansan A., Rusch, P., Landis, C. and Hatton, G.I. Effects of continuous environmental illumination on the hypothalamo­neurohypophysial system of the Sprague­Dawley rat. Brain Research Bull, (1995) in press.

Bergmann, B.M., Seiden, L.S., Landis, C.A., Gilliland, M.A. and Rechtschaffen, A. Sleep deprivation in the rat: XVIII. Regional brain levels of monoamines and their metabolites. Sleep 17 (1994) 583­9.

Landis, C.A. Pain. In M. Carskadon, Ed. Encyclopedia of Sleep and Dreaming. New York: Macmillan Publishing Co. 1992.

1. Affiliation: 1996-1997 Entry - Department of Psychiatry and Psychology, Sleep Study Unit University of Texas Southwestern Medical Center at Dallas

2. Name & Address: Roseanne Armitage, Ph.D.

Department of Psychiatry, Sleep Study Unit
The University of Texas Southwestern Medical Center
5323 Harry Hines Boulevard, Dallas, TX 75235-9070

Phone: (214) 648-8756;
FAX: (214) 648-5444;
E-mail: armitage@utsw.swmed.edu

3. Other Faculty:

Collaborators in Sleep: Gerald A. Marks, Ph.D. (Animal Neurophysiology), John H. Herman, Ph.D. (Children's Sleep Disorders, Vigilance and EEG); Robert F. Hoffmann, Ph.D. (Quantitative EEG, Sleep and Recovery); A. John Rush, M.D., Sleep and Depression); Jay Griffith, M.D. (Sleep and Schizophrenia); Trisha Suppes, M.D., Ph.D. (Sleep and Bipolar Illness); Chris Sinton, Ph.D. (Animal Models of Depression).

4. Types Of Training Available:

* Summer internships
* Foreign exchange fellowships
* Ph.D. program in clinical psychology
* 2 year post-doctoral and post-residency fellowships
* 4 year residency research program

5. Types Of Funding Available:

Potential for private funding, minority supplements, NIMH/NIH, Department support

6. Number and Names Of Current Trainees: (3) Ph.D. students.

Ph.D. Students: Rhonda Polakoff, Irma Aguilar, Kate McGraw

7. Students Who Have Completed Training In The Past Five Years and Current Status:
 

8. Primary Research Focus Of Laboratory:

+ Quantitative EEG analyses
+ Sleep physiology
+ Biological rhythms
+ Gender differences
+ Depression

9. Technical Capabilities Of The Lab:

* 6 bedroom human lab
* 2 neurophysiology labs equipped for 24-hour recording, chronic implant studies, and microiontophoresis
* The lab is completely "paperless" with on-line quantitative EEG analysis (PAA, PSA)
* Tympanic temperature measurement
* 24-hour blood sampling

10. Primary Training Focus:
 

11. Other Training Opportunities: Post-doctoral research fellowship in biology, physiology, biochemistry, and genetics

12. Representative Publications For Last Five Years:

Herman J, Casagrande M, DeGennaro L, Armitage R, Violani C, Bertini M, Roffwarg H: Ulteriori evidenze di una relazione di complementarità fra veglia e sonno REM nella direzione dei movimenti saccadici. II0 Congresso Nazionalell' Associazione Italiana Di Medicina Del Sonno (AIMS) 1992;94(suppl):78.

Armitage R, Roffwarg HP, Rush AJ: Digital period analysis of EEG in depression: Periodicity, coherence, and iterhemispheric relationships during sleep. Progress in Neuropsychopharmacology and Biological Psychiatry 1993;17:363-372.

Slegel D, Purdy D, Dao D, Armitage R, Roffwarg H: Differences in event related potential latency in normal individuals due to waking task demand compared to REM sleep eye movements. Sleep Research 1993;22:22.
 
Hendrickse WA, Armitage R, Husain M, Steinberg J, Roffwarg HP, Rush AJ: Digital period analysis of sleep EEG in schizophrenia and major depression. Sleep Research 1993;22:148.

Herman J, Casagrande M, DeGennaro L, Armitage R, Violani C, Bertini M, Roffwarg H: Aumento dei REMs verso sinistra in conseguenza dell'occlusione dell'emicampo visivo sinistro in veglia. In: Smirne S, Ferini Strambi L, Zucconi M (eds) Il Sonno In Italia - 1992, Milano Italy:Polletto Edizioni, 1993:264-269.

Hendrickse WA, Roffwarg HP, Grannemann BD, Orsulak PJ, Armitage R, Cain JW, Battaglia J, Debus JR, Rush AJ: The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study. Neuropsychopharmacology, 1994;10(2):85-91.

Armitage R, Rush AJ, Trivedi M, Cain J, Roffwarg HP: The effects of nefazodone on sleep architecture in depression. Neuropsychopharmacology, 1994;10(2):123-127.

Armitage R, Yonkers KA: Case report: Menstrual-related very short REM latency in a healthy normal control. Sleep, 1994;17(4):345-347.

Armitage R: Microarchitectural findings in sleep EEG in depression: Diagnostic implications. Biological Psychiatry, 1995;37:72-84.

Armitage R, Trivedi M, Rush AJ: Fluoxetine and oculomotor activity during sleep in depressed patients. Neuropsychopharmacology, 1995;12(2):159-165.

Armitage R, Rochlen A, Fitch T, Trivedi M, Rush AJ: Dream recall and major depression: A preliminary report. Dreaming, 1995;5(3):189-198.

Armitage R, Hudson A, Trivedi M, Rush AJ: Sex differences in the distribution of EEG frequencies during sleep: Unipolar depressed outpatients. Journal of Affective Disorders, 1995;34:121-129.

Armitage R, Hoffmann R, Fitch T, Morel C, Bonato R: A comparison of period amplitude and power spectral analysis of sleep EEG in normal adults and depressed outpatients. Psychiatry Research, 1995;56:245-256.

Armitage R, Debus J, Kiger B, Trivedi M, Cain J, Roffwarg HP, Rush AJ: Polysomnogram in major depressive and obsessive-compulsive disorders: A preliminary study. Depression, 1995;2:297-302.

Griffith JM, O'Neill JE, Armitage R, Garver DL: The effect of state on auditory P50 gating in schizophrenics and normals. Biological Psychiatry, 1995;37:682.

Shaffery JP, Fitch T, Speciale SG, Roffwarg HP, Armitage R, Marks GA: Sleep micro-architecture following bilateral mesencephalic lesions that eliminate PGO-waves. Sleep Research, 1995;24A:61.

1. Affiliation: Biobehavioral Nursing and Health Systems, Sleep Research Laboratory, School of Nursing, University of Washington, Seattle, WA

2. Names & Address: Carol Landis, DNSc, RN

Martha Lentz, PhD, RN
Joan Shaver, PhD, RN, FAAN
University of Washington School of Nursing Box 357266

Phone: (206) 616-1908;
FAX: (206) 543-4771;
E-Mail: calandis@u.washington.edu

3. Other Faculty:

Patricia Prinz, PhD and Michael Vitiello, PhD, run the Sleep and Aging Research Program, Dept of Psychiatry, study sleep patterns and fitness and sleep disorders in the elderly and in dementia;
David Avery, MD, PhD Dept of Psychiatry and Harborview Medical Center studies circadian rhythm disorders and light therapy.
Margaret Dimond, RN, PhD, FAAN studies light therapy for aggitated behaviors and sleep.
Karen Thomas, PhD, RN studies sleep and circadian rhythm development in neonates;
Marcia Killien, PhD, RN, FAAN studies sleep and fatigue in new parents;
Kathryn Barnard, PhD, RN, FAAN studies sleep in children and neonates;
Shawn Elmore, PhD, RN studies disorders of circadian rhythms and light therapy in women;
Susan Woods, PhD, RN studies circadian rhythms in the cardiovascular compromised.

4. Type Of Training Available:

We are involved in training at undergraduate and graduate programs in psychology, nursing, and medicine. Predoctoral students in psychology and in nursing have taken part in our research programs.

5. Types Of Funding Available:

Generally, predoctoral training support is through individual NRS Awards, teaching assistant and research assistant positions on funded grants, and general financial aid mechanisms. Prospective students should contact individual school programs or faculty to determine type of RA positions available.

Funds for postdoctoral research could be available through the Center for Women's Health Research, School of Nursing, University of Washington.

6. Number and Names Of Current Trainees:

Graduate Students: Derek Eder, Rita Cheek, Sharon Parkman, Diana McMillan.

7. Students Who Have Completed Training In The Past Five Years and Current Status :
 

8. Primary Research Focus Of Laboratory:

Women and sleep:
-Stress and reproductive correlates of insomnia in women
-Sleep in women with fibromyalgia

Cognitive, affective, behavioral function and sleep in older adults:
-Light therapy for aggitated behaviors and sleep.

Sleep deprivation effects:
-Neuroendocrineimmune interactions in animals and humans

9. Technical Capabilities Of The Lab:

+ Standard polysomnography
+ Spectral analysis
+ Surface electromyography
+ Home PSG recording via microprocessing unt
+ Automatic sleep and respiratory pattern scoring
+ Activity monitoring and circadian temperature monitoring of sleep in humans and in animals, animal sleep
+ Laboratory with 24 h monitoring and scoring systems
+ Biochemical assays for hormones, cytokines, histology, immuncytochemistry
+ Cell culture, immune assays

10. Primary Training Focus: Graduate training in nursing and psychology

11. Other Training Opportunities: No information provided

12. Representative Publications For Last Five Years:

Landis, C.A., Robinson, C.R. and Levine, J.D. Sleep fragmentation in the arthritic rat. Pain, 34 (1988) 93-99.

Shaver, J. & Giblin, E. (1989). Nursing and sleep research. Annual Review of Nursing Research, 7:71-93.

Landis, C.A., Robinson, C.R., Helms, C. and Levine, J.D. Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat model of chronic pain. Brain Research, 488 (1989) 195-201.

Landis, C.A., Levine, J.D. and Robinson, C.R. Decreased Slow-Wave and Paradoxical Sleep in a Rat Chronic Pain Model. Sleep, 12 (1989) 167-177.

Shaver J., Giblin, E., & Paulsen, V. (1991). Sleep Quality Subtypes in Midlife Women. Sleep, 14(1):18-23.

Paulsen, V. & Shaver, J. (1991). Stress, Support, Psychological States and Sleep. Social Science and Medicine, 32(11):1237-1243, 1991.

Landis, C.A., Bergmann, B.M., Ismail, M.M. and Rechtschaffen, A. Sleep Deprivation in the Rat: XV. Ambient Temperature Choice in Paradoxical Sleep Deprived Rats. Sleep, 15 (1992) 13-20.

Shaver, J. & Paulsen, V. (1993) Sleep Quality, Psychological Distress and Somatic Symptoms in Menopausal Women. J. of Family Practice Research, 13 (4):373-384.

Landis, C.A., Collins, B., Cribbs, L., Sukhatme, V., Bergmann, B.M., Rechtschaffen, A, Smalheiser, N. Expression of EGR-1 in brain of sleep deprived rats. Molecular Brain Research, 17 (1993) 300-6.

Bergmann, B.M., Landis, C.A., Zenko, C. E., and Rechtschaffen, A. Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature. Sleep, 16 (1993) 221-5.

Bergmann, B.M., Seiden, L.S., Landis, C.A., Gilliland, M.A., and Rechtschaffen, A. Sleep Deprivation in the Rat: XVIII. Regional brain levels of monoamines and their metabolites. Sleep, 17 (1994) 583-9.

Dimond, M., Lentz, M., & Shaver, J. (1994, May) Light Therapy for Agitation in Dementia: A Pilot Study. Paper presented at International Nursing Research Conference, Vancouver, Canada.

Landis, C.A., Savage, M., Lentz, M. and Brengelmann, G. Sleep deprivation alters body temperature level and dynamics, not the threshold for sweating. Sleep Research, 24 (1995) 446.

Shaver, J.L.F., Lentz, M. Landis, C.A., Heitkemper, M.M, Buchwald, D.S., Woods, N.F. Fibromyalgia in women: Sleep, psychological distress and stress arousal. Sleep Research, 24 (1995) 430.

Landis, C.A., Tsuji, J., Lentz, M., Shaver, J., Pollack, S. REM sleep deprivation effects on NK-cell cytotoxicity and lymphocyte subpopulations from peripheral blood in male rats. Sleep Research, 25, (1996) in press.

Landis, C.A. Altered sleep patterns with the platform method of REM sleep deprivation in rats. Sleep Research, 25, (1996) (in press).